美沙利钠/茶碱(Mersalyl Sodium/Theophylline)

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

WATSON LABS INC

在研机构-

非在研机构

WATSON LABS INC

最高研发阶段撤市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构

分子式C7H8N4O2

InChIKeyZFXYFBGIUFBOJW-UHFFFAOYSA-N

CAS号58-55-9

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关联

100 项与美沙利钠/茶碱相关的临床结果

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100 项与美沙利钠/茶碱相关的转化医学

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100 项与美沙利钠/茶碱相关的专利（医药）

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4

项与美沙利钠/茶碱相关的文献（医药）

1969-05-01·Experimental Neurology2区 · 医学

Effects of diuretics on cerebrospinal fluid formation and potassium movement

2区 · 医学

Article

作者: Floyd R. Domer

The effects of a number of diuretics upon the rate of formation and movement of K into another body fluid, viz. cerebrospinal fluid (CSF) were determinedAminometradine, mersalyl-theophylline, hydrochlorothiazide, chlorothiazide, triamterene, ethacrynic acid, and acetazolamide all significantly decreased the rate of CSF formation.Only, spironolactone significantly increased the rate of CSF formation.A number of the diuretics significantly altered the movement of 42K into the perfusing CSF, but in a manner which did not parallel their actions on the rate of CSF formation.The process involved in CSF formation and K exchange between plasma and CSF appear to be different and independent.

1959-04-01·The Journal of pharmacology and experimental therapeutics

Comparative effects of chlorothiazide and mersalyl (mersalyl sodium and theophylline) on the kidney.

Article

作者: BLACKMORE, W P

1958-07-01·Acta Pharmacologica et Toxicologica

The Influence of the Mersalyl – Theophylline complex on Connective Tissue.

Article

作者: A. Schmidt ; E. Hvidberg ; J. Schou

Rabbits or mice pretreated with mersalyl-theophylline, or given the diuretic locally in the spreading fluid, did not show any spreading action.The diuretic had no action on the subcutaneous absorption of saline or urethan.Low doses of the diuretic did not alter the hexosamine or water contents of the peripheral connective tissue.High doses reduced hexosamine content but did not change the water content.This neg. effect on connective-tissue-water content was found in all of the normal animals used.It is suggested that the toxicity of mersalyl is reduced by equimolar amounts of theophylline because of complex formation.

100 项与美沙利钠/茶碱相关的药物交易

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