Mersalyl Sodium/Theophylline

The effects of a number of diuretics upon the rate of formation and movement of K into another body fluid, viz. cerebrospinal fluid (CSF) were determinedAminometradine, mersalyl-theophylline, hydrochlorothiazide, chlorothiazide, triamterene, ethacrynic acid, and acetazolamide all significantly decreased the rate of CSF formation.Only, spironolactone significantly increased the rate of CSF formation.A number of the diuretics significantly altered the movement of 42K into the perfusing CSF, but in a manner which did not parallel their actions on the rate of CSF formation.The process involved in CSF formation and K exchange between plasma and CSF appear to be different and independent.