西番莲提取物(Passiflora incarnata extract) - 在研适应症：入睡和睡眠障碍_专利_临床

概要

基本信息

药物类型

中药

别名

Pascoflair

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病

在研适应症

入睡和睡眠障碍

非在研适应症-

原研机构

Pascoe Natural Healthcare

在研机构

Pascoe Natural Healthcare

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

9

项与西番莲提取物相关的临床试验

TCTR20250304004

/ Not yet recruiting临床2期IIT

Efficacy of Passiflora incarnata (flower part) extract in participants with insomnia disorder: A Randomized Controlled Trial

开始日期2025-03-01

申办/合作机构

Dhurakij Pundit University

RBR-4knsh9z

/ Terminated临床2期IIT

Use of Zolpidem and Passiflora incarnata to control dental anxiety in third molar surgery: a controlled, randomized, triple-blind clinical study

开始日期2021-10-20

申办/合作机构

Universidade Estadual Paulista Júlio De Mesquita Filho Unesp

[+1]

NCT03780595

/ Unknown status临床4期

Efficacy and Safety of the Administration of the Passiflora Extract for Benzodiazepine Withdrawal in Institutionalized Older Adults: Clinical Trial Phase III

The aim of this clinical trials is compare the percentage of patient who achieve a reduction equal to or greater than 50% in the dose of benzodiazepines at 10 weeks of treatment.

开始日期2018-09-27

申办/合作机构

Nutrición Médica SL

100 项与西番莲提取物相关的临床结果

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100 项与西番莲提取物相关的转化医学

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100 项与西番莲提取物相关的专利（医药）

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10

项与西番莲提取物相关的文献（医药）

2025-04-01·Brain Research

Passiflora incarnate extract attenuates neuronal loss and memory impairment in stressed rats

Article

作者: Khorasgani, Elham Moghtadaei ; Meftahi, Gholam Hossein ; Dehghani, Mohammad Amin

The present study investigated the protective effects of hydroalcoholic Passiflora incarnate extract on memory, anxiety-like behaviors, inflammatory factors, and cell density in the brain following stress. This study randomly divided 40 adult Wistar rats into 5 groups: control, normal saline, stress, stress + Passiflora incarnata, and Passiflora incarnata groups. For 21 consecutive days, the stress group and the Passiflora incarnata + stress group were exposed to immobilizing stress for 2 h each day. The Passiflora incarnata and the stress + Passiflora incarnata groups were gavaged with Passiflora incarnata extract half an hour before stress for 21 days. One day after the last stress, the Barnes and elevated plus maze were used to measure learning, memory, and anxiety-like behavior, respectively. Additionally, the MDA (malondialdehyde), TNF-α, IL-1, and gamma-glutamyl transferase (GGT) factors in the serum, as well as the cell density in the hippocampus, amygdala, and prefrontal regions, were investigated. The results of the Barnes maze showed that immobility stress increases the number of errors and the distance traveled to reach the target hole. Administering Passiflora incarnata extract prior to stress led to fewer errors and a shorter distance covered to reach the target hole. The use of Passiflora incarnata before stress in the elevated plus maze reduced anxiety-like behaviours (less frequent entries into the open arm, reduced duration of time in the open arm) compared to the stress group. The stress group caused a significant enhance in MDA, TNF-α, and IL-1 and a decrease in GGT, while treatment with Passiflora incarnata significantly improved these factors than the stress group. The immobility stress caused a significant decrease in cell density in the hippocampus, amygdala, and prefrontal region, and treatment with Passiflora incarnata increased cell density in these areas than the stress animals. In conclusion, Passiflora incarnata improves learning and memory impairment, anxiety-like behaviors, inflammatory factors, and damage caused by stress in the hippocampus, amygdala, and prefrontal areas.

2024-03-20·Cureus

Randomized, Double-Blind, Placebo-Controlled, Clinical Study of Passiflora incarnata in Participants With Stress and Sleep Problems

Article

作者: Tamoli, Sanjay ; Harit, Mahesh Kumar ; Agarwal, Ankit ; Pawar, Vinay ; Mundhe, Narendra ; Mahadik, Swapnali ; Bhapkar, Vedvati ; Kolhe, Ganesh ; Kulkarni, Anand

Background and objectives SIVI is a standardized extract prepared using the aerial parts of Passiflora incarnata developed to enhance the quality of sleep. The objective of the present study was to the evaluate efficacy and safety of SIVI (Passiflora incarnata extract) in the management of stress and sleep problems in Indian participants in a randomized, double-blind, placebo-controlled, clinical study. Materials and methods A total of 65 participants with stress and insomnia were randomized to two groups with 32 in the SIVI (Passiflora incarnata extract) group and 33 in the placebo group. Subjects were asked to take the test substance along with water at bedtime for 30 days. The Perceived Stress Scale, quality of life using the General Health Questionnaire (GHQ-12) scale, and Insomnia Severity Index were assessed on day 1, day 15, and day 30. Results Passiflora incarnata extract showed a statistically significant reduction in the mean score of stress on the Perceived Stress Scale and significantly increased the mean score of total sleep time compared to placebo. The general psychological health was found to be significantly improved in the SIVI (Passiflora incarnata extract) group compared to the placebo group on day 15 and day 30. SIVI (Passiflora incarnata extract) did not show any adverse effects. Conclusions The results of the current study indicate that Passiflora incarnata extract is beneficial in the management of stress and helps to improve sleep quality in subjects with stress and insomnia.

2016-01-01·Medicina Oral Patología Oral y Cirugia Bucal4区 · 医学

Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction

4区 · 医学

Article

作者: de Almeida-Souza, L-M ; de Oliveira-Ribeiro, A ; Dantas, L-P ; Groppo, F-C

BACKGROUNDAnxiety symptoms are frequently observed in dental patients, whether they are undergoing simple or more invasive procedures such as surgery. This research aimed to compare the effects of Passiflora incarnata and midazolam for the control of anxiety in patients undergoing mandibular third molar extraction.MATERIAL AND METHODSForty volunteers underwent bilateral extraction of their mandibular third molars in a randomized, controlled, double-blind, crossover clinical trial. Passiflora incarnata (260 mg) or midazolam (15 mg) were orally administered 30 minutes before surgery. The anxiety level of participants was evaluated by questionnaires and measurement of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2).RESULTSConsidering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2. Over 70% of the volunteers responded that they felt quiet or a little anxious under both protocols. With midazolam, 20% of the participants reported amnesia (not remembering anything at all), while Passiflora showed little or no ability to interfere with memory formation.CONCLUSIONSPassiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars.

100 项与西番莲提取物相关的药物交易

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研发状态

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适应症	国家/地区	公司	日期
入睡和睡眠障碍	德国	Pascoe Natural Healthcare	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01665170 (CTgov)	临床3期	-	60	Placebo (Placebo)	糧鹽觸製艱選艱選糧壓(顧鏇鹹膚繭艱繭繭簾鹹) = 壓壓鬱積積積製獵壓襯壓製艱壓膚遞夢齋餘餘 (鏇夢醖艱壓網醖網夢膚, 醖觸鬱製繭糧憲蓋願醖 ~ 範範製醖膚願鏇獵窪衊) 更多	-	2015-12-09
				Passiflora incarnata (Verum)	糧鹽觸製艱選艱選糧壓(顧鏇鹹膚繭艱繭繭簾鹹) = 顧遞襯憲範夢膚積獵衊壓製艱壓膚遞夢齋餘餘 (鏇夢醖艱壓網醖網夢膚, 窪壓蓋壓選鏇蓋遞淵鑰 ~ 鑰鏇築夢廠憲鏇蓋顧鬱) 更多