PSP-0012(PSP-0012) - 药物靶点：IFNGR_在研适应症：慢性乙型肝炎_专利_临床

概要

基本信息

药物类型

细胞因子

别名

靶点

IFNGR

作用机制

IFNGR拮抗剂(干扰素γ受体复合体拮抗剂)

治疗领域

感染消化系统疾病

在研适应症

慢性乙型肝炎

非在研适应症-

原研机构

德益阳光生物技术（北京）有限责任公司

在研机构

德益阳光生物技术（北京）有限责任公司

非在研机构-

最高研发阶段临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

100 项与 PSP-0012 相关的临床结果

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100 项与 PSP-0012 相关的转化医学

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100 项与 PSP-0012 相关的专利（医药）

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1

项与 PSP-0012 相关的文献（医药）

1997-08-01·Prostaglandins, Leukotrienes and Essential Fatty Acids3区 · 医学

Role of cytosolic phospholipase A2 in eicosanoid generation by corpora lutea of pseudopregnant rats: effects of its specific inhibitor

3区 · 医学

Article

作者: Kawaminami, M. ; Kurusu, S. ; Hashimoto, I. ; Noguchi, T.

This study was performed to investigate whether 85 kDa cytosolic phospholipase A2 (cPLA2) functions in eicosanoid generation in rat corpora lutea (CL) using its specific inhibitor, arachidonyl trifluoromethyl ketone (ATK). In both immature and adult pseudopregnant rats, PLA2 activity in the cytosol of CL, measured by the liposome-vesicle assay, increased from day 6 of pseudopregnancy (PSP6) to PSP12. 10 microM ATK potently inhibited all of these activities to 10-20% and the rate of the inhibition by ATK was much higher on PSP12. ATK also reduced arachidonic acid (AA) release from luteal cells of PSP12 prelabelled with 3H-AA. Furthermore, the production of prostaglandin E2 by cultured luteal cells was mostly suppressed by the drug. These results suggest the augmentation of cPLA2 activity with the luteal age of pseudopregnant rats and its principal role in eicosanoid generation in CL.

100 项与 PSP-0012 相关的药物交易

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