A multicenter, randomized, parallel controlled clinical study of Chuanbei Qing - Magnesium sulfate sodium sulfate and potassium sulfate concentrate oral solution for intestinal preparation before colonoscopy in adult patients

开始日期2023-10-15

申办/合作机构-

NCT06051955 / RecruitingN/AIIT

Evaluation of an Oral Sodium Sulfate Solution for Patients With Prior Difficult or Incomplete Cleansing, a Progressive Case Series.

This case series aims to evaluate the effectiveness and tolerability of Oral Sulfate Solution (OSS) in patients who had previously experienced poor colonoscopy preparation.

开始日期2023-10-11

申办/合作机构

Queen's University

[+1]

NCT05877911 / Not yet recruiting临床2期IIT

Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy: a Multi-center Prospective Randomized Controlled Trial.

Ovarian cancer is the most lethal malignancy of the female genital tract. Cytoreductive surgery combined with chemotherapy is the primary treatment for ovarian cancer, and radical tumor resection is an important means to improve the prognosis. However, even after complete tumor resection, 75% of patients with ovarian cancer still recur within 3 years after the initial treatment and eventually die from recurrence. In ovarian cancer, the lesions are located primarily in the peritoneal cavity. High-grade evidence demonstrates that the use of intraperitoneal hyperthermic chemotherapy (HIPEC) with cisplatin after cytoreductive surgery significantly improves the outcome in some patients with ovarian cancer. Currently, this is the only non-pharmacologic treatment that reduces both the risk of recurrence and death from ovarian cancer with a multi treatment. However, HIPEC with cisplatin can lead to acute kidney injury, and a serious complication that can seriously affect the short and long-term prognosis of patients. Sodium thiosulfate has previously been reported to reduce the incidence of acute kidney injury after HIPEC with cisplatin, but this finding has not been confirmed in a high-level study. Therefore, we propose a multi-center, prospective, open-label, randomized, controlled trial including 110 patients with ovarian cancer who received HIPEC with cisplatin, to evaluate whether sodium thiosulfate combined with hydration (55 patients in the trial group) can reduce the incidence of acute kidney injury after HIPEC with cisplatin compared with hydration alone (55 patients in the control group), and to provide high-level evidence for the rationale of using sodium thiosulfate for nephrotoxicity relief in cisplatin HIPEC.

开始日期2023-05-01

申办/合作机构

Sun Yat-Sen Memorial Hospital

[+1]

100 项与 Sodium Sulfate 相关的临床结果

登录后查看更多信息

100 项与 Sodium Sulfate 相关的转化医学

登录后查看更多信息

100 项与 Sodium Sulfate 相关的专利（医药）

登录后查看更多信息

2,029

项与 Sodium Sulfate 相关的文献（医药）

2025-02-01·JOURNAL OF COLLOID AND INTERFACE SCIENCE

Investigating the interactions between an industrial lipase and anionic (bio)surfactants

Article

作者: Otzen, Daniel E. ; Otzen, Daniel E ; Pedersen, Jan Skov ; Hernández, Marcos López ; López Hernández, Marcos

In laundry formulations, synergies between amphiphiles and other additives such as enzymes increase sustainability through a large decrease in energy consumption. However, traditional surfactants are derived from petroleum, requiring chemical modifications (sulfonation, ethoxylation, or esterification) and generating environmental pollution through toxicity and low degradability. Use of biosurfactants removes these issues. To provide a firmer basis for the use of biosurfactants, we report on the interactions between the industrial lipase LIPEX® and three common biosurfactants, rhamnolipids, sophorolipids, and surfactin. The model surfactant sodium dodecyl sulfate (SDS) is included in the study for comparison. A thorough characterization by Small-angle X-ray scattering (SAXS) provides valuable information on the enzyme's oligomerization and the surfactant micelles' ellipsoidal morphology. Additionally, the enzymatic activity and complex formation in different surfactant mixtures are studied using isothermal titration calorimetry, activity assays, and SAXS. SDS activates the enzyme while promoting a controlled association of monomers while the biosurfactants inhibit the enzyme, independent of their effects on its quaternary structure. Rhamnolipids and surfactin promote lipase dimerization while sophorolipids have no significant effect on lipase quaternary structure. Based on these data, we propose a partial replacement that allows the enzyme to retain enzymatic activity while improving the environmental footprint of the formulation.

2024-12-31·Pharmaceutical biology

Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs

Article

作者: Songvut, Phanit ; Boonyarattanasoonthorn, Tussapon ; Junsai, Thammaporn ; Kongratanapasert, Teetat ; Nuengchamnong, Nitra ; Khemawoot, Phisit ; Supannapan, Kittitach

CONTEXT:

The therapeutic potential of andrographolide is hindered by its poor oral bioavailability and unpredictable pharmacokinetics, primarily due to its limited water solubility.

OBJECTIVE:

This work aimed to enhance the solubility and pharmacokinetics of andrographolide, a bioactive compound in Andrographis paniculata (Burm. f.) Nees (Acanthaceae), using solubilizing agents and a bioenhancer.

MATERIALS AND METHODS:

Four groups of beagles were compared: (1) A. paniculata powder alone (control), (2) A. paniculata powder with 50% weight/weight (w/w) β-cyclodextrin solubilizer, (3) A. paniculata powder with 1% w/w sodium dodecyl sulfate (SDS) solubilizer, and (4) A. paniculata powder co-administered with 1% w/w SDS solubilizer and 10% piperine bioenhancer. All groups received a consistent oral dose of 3 mg/kg of andrographolide, administered both as a single dose and multiple doses over seven consecutive days.

RESULTS:

Thirteen chemical compounds were identified in A. paniculata powder, including 7 diterpenoids, 5 flavonoids, and 1 phenolic compound. A. paniculata co-administration with either 50% w/w β-cyclodextrin or 1% w/w SDS, alone or in combination with 10% w/w piperine, significantly increased systemic andrographolide exposure by enhancing bioavailability (131.01% to 196.05%) following single and multiple oral co-administration. Glucuronidation is one possible biotransformation pathway for andrographolide, as evidenced by the excretion of glucuronide conjugates in urine and feces.

CONCLUSION:

The combination of solubilizing agents and a bioenhancer improved the oral bioavailability and pharmacokinetics of andrographolide, indicating potential implications for A. paniculata formulations and clinical therapeutic benefits. Further investigation in clinical studies is warranted.

2024-12-01·ECOTOXICOLOGY

Sensitivity assessment of Biomphalaria glabrata (SAY, 1818) using reference substance sodium dodecyl sulfate for ecotoxicological analyzes

Article

作者: Tallarico, Lenita de Freitas ; Silva, Fábio Nunes Vieira da ; Miranda, Marcel Sabino ; Nakano, Eliana

Sodium dodecyl sulfate (SDS) is a surfactant used and recommended by regulatory agencies as a reference substance in ecotoxicological analyzes. In this work, acute toxicity assays were performed with adults and embryos of the freshwater snail Biomphalaria glabrata, an endemic organism with environmental and public health importance, to evaluate the effects of the surfactant and establish a sensitivity control chart. The organisms were exposed to SDS for 24 h to a range of concentrations, as well as a control group. Six assays were performed to establish the control chart for adults (with a median LC₅₀ of 36.87 mg L^-1) and differential sensitivity was observed at each embryonic stage (EC₅₀ = blastulae 33.03, gastrulae 35.03, trochophore 39.71 and veliger 72.55 mg L^-1). The following behavioral responses were observed in exposed adult snails: release of hemolymph and mucus, body outside the shell, and penile overexposure. Embryos at the blastulae and gastrulae stages were more sensitive, and teratogenic effects were accentuated in the trochophore stage. The difference in results obtained between adults and embryos underscore the importance of carrying out analyzes at different developmental stages. The serial assays established with SDS for B. glabrata demonstrated efficiency and constancy conditions in the assays with good laboratory practice standards. The wide distribution of Biomphalaria species in several countries, their easy maintenance and cultivation in the laboratory, in addition to ecological importance, make them economical alternatives for ecotoxicological assays.

项与 Sodium Sulfate 相关的新闻（医药）

2024-06-22

·生物探索

Nature Medicine | 突破传统观点：炎症如何改变结肠癌起源细胞

引言在传统观点中，结肠癌起源于干细胞。然而，炎症是结肠癌的主要风险因素之一，它能够抑制肠道干细胞的特性。6月20日Nature Genetics报道的研究”Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation“，以帕内斯细胞(Paneth cells)为模型，评估在炎症背景下，已分化的细胞谱系是否能触发小鼠肠道肿瘤的形成。在炎症的作用下，帕内斯细胞中Apc基因的特异性突变导致了类似于炎症性肠病患者及较大部分人类散发性结肠癌的肠道肿瘤。这可能是由于西方饮食习惯引发的炎症反应，而这种饮食习惯是结肠癌的一个主要风险因素。利用旨在预测癌症起源细胞的机器学习方法，研究人员发现，在相当一部分散发性结肠癌病例中，其起源细胞并非干细胞，而是分泌细胞谱系。大多数癌症被认为起源于具有干细胞或祖细胞特性的细胞，这些细胞具备活跃增殖、自我更新和分化的能力。这一点在小鼠肠道中得到了证明，当Apc肿瘤抑制基因的功能丧失突变发生在Lgr5+肠道干细胞时，成功引发了腺瘤的形成。然而，当相同的Apc突变引入到更成熟、寿命更短的转运放大细胞中时，肿瘤的形成在早期微腺瘤阶段被阻止。然而，除了这种“自上而下”的模式，肠道肿瘤发生的“自下而上”模型也被提出，在这种模型中，位于隐窝-绒毛轴较高位置的更成熟的肠道细胞在组织损伤和炎症的背景下可能会启动癌症。西方饮食习惯和慢性炎症是与消化道散发性恶性疾病风险增加相关的两大主要病因因素，被认为会引发肠道上皮中的特定细胞和分子改变，最终导致肿瘤发生和进展目标细胞的扩展。帕内斯细胞是位于小肠隐窝底部的特化分泌细胞，能够向肠腔分泌抗菌肽。此外，它们还提供必要的物理支持，并分泌信号以维持Lgr5+干细胞的功能。在结肠中，虽然没有帕内斯细胞，但Kit+帕内斯样细胞（也称为深隐窝分泌细胞）在功能上与小肠中的帕内斯细胞类似，也扮演分泌和微环境支持的角色。在该研究中，研究人员利用帕内斯细胞作为模型，证明其在炎症背景下具有去分化和肿瘤形成的能力。研究结果显示，在炎症背景下，帕内斯细胞可以通过Apc基因的失活突变引发肠道腺瘤的形成。当Apc突变与Kras或Trp53基因突变结合时，即使没有炎症刺激，也会显著增加帕内斯细胞衍生肿瘤的数量并加速其向恶性表型的转化。进一步的分子标记分析表明，帕内斯细胞衍生的肿瘤与Lgr5+干细胞衍生的肿瘤在组织学和基因表达模式上存在显著差异，反映了其在肿瘤发生过程中不同的细胞命运和信号通路的激活。综上所述，该研究揭示了肠道肿瘤发生的另一条“自下而上”的途径，即帕内斯细胞在炎症背景下能够去分化并形成肿瘤。这一发现对于理解炎症性肠病相关癌症以及饮食引发的结肠癌具有重要意义，并可能为新的治疗策略提供依据。结肠癌（Colorectal Cancer, CRC）是全球范围内发病率和致死率均居高不下的恶性肿瘤类型之一。传统上，研究认为CRC的起源主要与干细胞相关。然而，越来越多的证据表明，炎症在结肠癌的发生和发展中扮演着重要角色。炎症性肠病（Inflammatory Bowel Disease, IBD）患者的结肠癌风险显著增加，这提示炎症可能通过影响肠道上皮细胞的功能和特性，诱导肿瘤形成。该研究通过以下几种主要方法来探讨帕内斯细胞在肠道肿瘤形成中的作用：基因操作：使用Cre-loxP系统特异性地在帕内斯细胞中引入Apc、Kras和Trp53基因突变。具体而言，通过将含有这些基因突变的loxP小鼠与表达帕内斯细胞特异性Cre重组酶的Lyz1-CreERT2小鼠进行杂交，生成携带特定基因突变的帕内斯细胞。这些基因突变已知在结肠癌的发生中起关键作用。炎症诱导：采用二硝基硫酸钠（Dextran Sodium Sulfate, DSS）诱导小鼠肠道炎症。DSS通过饮水方式给予小鼠，能够引发类似于人类炎症性肠病的肠道炎症反应。研究中，DSS溶液浓度为2%，持续时间根据实验设计而定。对从小鼠肠道上皮细胞中分离的单个细胞进行RNA测序，分析不同基因突变和炎症条件下的细胞转录组变化。通过使用10x Genomics平台，研究人员能够获得高分辨率的单细胞转录组数据。通过qPCR技术检测肿瘤组织中特定基因的表达水平，如Lyz1和Dclk1。使用抗体标记技术对肿瘤组织切片进行染色，观察特定蛋白质的表达和分布。研究中使用了抗β-连环蛋白（β-catenin）、LYZ1和DCLK1抗体，以评估肿瘤细胞的标志物表达情况。帕内斯细胞的去分化和肿瘤形成在炎症背景下（DSS处理），帕内斯细胞中Apc基因突变能够引发肠道腺瘤形成。数据表明，在给予DSS的条件下，Apc突变小鼠的肠道腺瘤发生率显著增加（p < 0.001）。当Apc突变与Kras或Trp53基因突变结合时，即使没有DSS诱导的炎症，这些小鼠仍表现出显著的肿瘤形成。数据表明，帕内斯细胞中Apc和Kras双突变的小鼠肿瘤发生率增加了6.1倍，而Apc和Trp53双突变的小鼠肿瘤发生率增加了1.6倍（均无DSS处理）。转录组分析单细胞RNA测序结果显示，在帕内斯细胞中引入Apc突变并施加DSS诱导的炎症条件下，帕内斯细胞表现出特异性的转录组变化，标志着其去分化为肿瘤起源细胞。帕内斯细胞中与干细胞相关的基因（如Cd81和Prom1）的表达显著上调，而与分化相关的基因（如Lyz1）的表达显著下调。 qPCR数据支持这一发现，显示在帕内斯细胞衍生的肿瘤中，Lyz1表达水平较低（p = 7.5 × 10^-4），而Dclk1表达水平较高（p < 0.001）。免疫组化验证免疫组化分析显示，帕内斯细胞衍生的肿瘤中，β-连环蛋白（β-catenin）的核和细胞质积聚显著增加，这与肿瘤细胞的去分化和增殖有关。 LYZ1和DCLK1的免疫染色结果表明，在帕内斯细胞衍生的肿瘤中，LYZ1阳性细胞比例较低，而DCLK1阳性细胞比例较高。这一结果与qPCR数据一致，进一步验证了帕内斯细胞在特定条件下的去分化能力。炎症激活了结肠中不同的肿瘤起源细胞（cells-of-origin）（Credit: Nature Medicine） a. 未处理的小鼠、给予3% DSS处理7天的小鼠，以及分别喂养AIN-76A或NWD1合成饮食3个月的小鼠。分析这些小鼠的结肠组织中增殖性深隐窝分泌细胞（DCS cells）的存在。使用WGA染色标记DCS细胞，用Ki67标记增殖细胞，DAPI对细胞核进行对比染色。图中星号标记的是WGA和Ki67双阳性细胞。 b. WGA+Ki67+ 细胞的量化：在图a中，通过统计下结肠隐窝底部的WGA和Ki67双阳性细胞的数量，显示了DSS处理和不同饮食对DCS细胞增殖的影响。 c. WGA+ 细胞的总量化：统计下结肠隐窝底部的WGA阳性细胞总数。 d. 预测肿瘤起源细胞：使用COOBoostR计算方法预测IBD相关结肠癌（IBD-CRC, n=25）和散发性结肠癌（sCRC, n=257）的肿瘤起源细胞。条形图显示了不同起源细胞在IBD-CRC和sCRC中的分布。 e. 免疫组化分析：健康对照和IBD患者的结肠组织，使用MUC2、BEST4和Ki67进行免疫组化分析，星号标记双阳性细胞。 f. 增殖细胞的百分比：溃疡性结肠炎（UC）患者和健康对照，显示增殖（Ki67+）的MUC2+和REG4+细胞在UC患者和健康对照中的百分比。数据来自12名健康参与者和17名UC患者。 g. 干细胞指数：IBD-CRC和sCRC亚组中具有RNA测序数据的病例（n=27干细胞，n=10杯状细胞）。 h. CMS映射：根据预测的肿瘤起源细胞分层的肿瘤样本。图显示了CMS（共识分子亚型）在不同肿瘤起源细胞中的分布，P值为Fisher精确检验结果。研究得出的模型显示结肠癌可以从干细胞（ISC）或分化细胞起源，后者在炎症刺激下被激活。再生性干细胞（RSC）重新编程在支持再生反应中被激活。在这个过程中，活跃分裂的RSC扩大了肿瘤启动和进展的细胞目标，导致一种以炎症表型为特征的肿瘤发生替代途径。近年来，针对肿瘤起源细胞的研究不断深入，揭示了不同类型细胞在肿瘤发生中的潜在贡献。例如，有研究发现，胃肠道中的特定细胞类型在特定病理条件下能够去分化并获得干细胞特性，从而成为肿瘤的起源细胞。这一发现不仅挑战了传统的肿瘤起源理论，也为肿瘤预防和治疗提供了新的思路。此外，随着单细胞测序技术的发展，研究人员能够更精确地解析肿瘤微环境中不同细胞类型的作用和相互关系。例如，该研究通过单细胞RNA测序揭示了帕内斯细胞在炎症背景下的转录组变化，提供了新的视角来理解炎症性肠病相关癌症的发生机制。该研究通过小鼠模型和基因操作技术，揭示了帕内斯细胞在结肠癌发生中的关键作用。这一发现不仅为理解结肠癌的发生机制提供了新的视角，也为未来的癌症预防和治疗策略提供了新的靶点。特别是针对炎症性肠病患者的结肠癌预防和治疗，该研究的结果具有重要的临床意义。综上所述，该研究通过多种实验手段和先进技术，揭示了帕内斯细胞在特定病理条件下的去分化和肿瘤形成能力。这一发现不仅拓展了我们对结肠癌发生机制的理解，也为未来的研究和治疗提供了重要的参考。随着技术的发展和研究的深入，有望进一步揭示肿瘤起源细胞的多样性和复杂性，为肿瘤防治开辟新的道路。参考文献 Verhagen MP, Joosten R, Schmitt M, Välimäki N, Sacchetti A, Rajamäki K, Choi J, Procopio P, Silva S, van der Steen B, van den Bosch TPP, Seinstra D, de Vries AC, Doukas M, Augenlicht LH, Aaltonen LA, Fodde R. Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation. Nat Genet. 2024 Jun 20. doi: 10.1038/s41588-024-01801-y. Epub ahead of print. PMID: 38902475. https://www.nature.com/articles/s41588-024-01801-y 责编|探索君排版|探索君转载请注明来源于【生物探索】 End 往期精选围观一文读透细胞死亡(Cell Death) | 24年Cell重磅综述（长文收藏版）热文 Cell | 是什么决定了细胞的大小？热文 Nature | 2024年值得关注的七项技术热文 Nature | 自身免疫性疾病能被治愈吗？科学家们终于看到了希望热文 CRISPR技术进化史 | 24年Cell 综述

2023-08-30

·Science Daily

Direct formation of sulfuric acid in the atmosphere

In the atmosphere, gaseous sulfuric acid can form particles that influence the physical properties of clouds. Thus, the formation of sulfuric acid in the gas phase directly affects the radiative forcing and Earth's climate. In addition to the known formation from sulfur dioxide, researchers have now been able to demonstrate through experiments that there is another formation pathway that has been speculated about for decades. Sulfuric acid in the atmosphere can also be formed directly by the oxidation of organic sulfur compounds. This new production pathway can be responsible for up to half of the gaseous sulfuric acid formation over the oceans and is thus of high importance for climate projections -- especially over the oceans of the Southern Hemisphere. In the atmosphere, gaseous sulfuric acid can form particles that influence the physical properties of clouds. Thus, the formation of sulfuric acid in the gas phase directly affects the radiative forcing and Earth's climate. In addition to the known formation from sulfur dioxide, researchers at the Leibniz Institute for Tropospheric Research (TROPOS) have now been able to demonstrate through experiments that there is another formation pathway that has been speculated about for decades. Sulfuric acid in the atmosphere can also be formed directly by the oxidation of organic sulfur compounds. This new production pathway can be responsible for up to half of the gaseous sulfuric acid formation over the oceans and is thus of high importance for climate projections -- especially over the oceans of the Southern Hemisphere, as the researchers write in the journal Nature Communications. Organic sulfur compounds are mainly emitted from biogenic sources and contribute significantly to Earth's sulfur cycle. The sulfur cycle is important for Earth's climate because the oxidation products of organic sulfur compounds, such as sulfuric acid (H2SO4) and methanesulfonic acid (MSA, CH3SO3H), initiate new particle formation. Sulfate particles scatter incoming solar radiation efficiently and affect the formation of cloud condensation nuclei (CCN). Number and size of CCN significantly change the microphysical and radiative properties as well as the lifetime of clouds. Hence, knowledge of how H2SO4 is formed in the atmosphere is mandatory to understand fundamental processes in the climate system. On global scale, with an annual emission rate of about 30 million tons of sulfur, the most important organic sulfur compound is dimethyl sulfide (DMS, CH3SCH3) followed by methyl mercaptan (MeSH, CH3SH) and, to a lesser extent, dimethyl disulfide (DMDS, CH3SSCH3). Numerous laboratory experiments and model simulations were performed at TROPOS to investigate the atmospheric oxidation pathways of these compounds. "To our knowledge, there is so far no experimental evidence for the direct formation of H2SO4 in the gas phase, except via SO2 oxidation by OH radicals or Criegee intermediates, although this has long been speculated about in the literature and even such pathways are implemented in models," explains Dr. Torsten Berndt of TROPOS. At TROPOS, experimental proof of direct H2SO4 formation has now been achieved, using two flow systems: a horizontal free-jet flow system and a vertical laminar flow tube. With these systems, it was possible to work under different reaction conditions, which allowed an exact investigation of the oxidation processes by using advanced mass spectrometric techniques. In addition, the experimental findings allow the estimation of many kinetic parameters in the sulfur oxidation cycle and thus contribute to an improved understanding of its atmospheric oxidation. The experimental results were integrated into the complex multiphase chemistry mechanism MCM/CAPRAM existing at TROPOS for model evaluation. "Under the relatively pristine conditions over the Southern oceans, the direct formation of H2SO4 can contribute up to 50% to the total gas phase formation," report Dr. Andreas Tilgner and Dr. Erik H. Hoffmann. It is postulated that the direct gas-phase formation may be especially important over oceans in the Southern Hemisphere. These regions are often characterized by small SO2-to-DMS ratios, which means that the fraction of this direct production pathway can be important there. Other atmospheric regions, where small SO2-to-DMS ratios are expected, are in the outflow regimes of marine clouds. There, high H2SO4 concentrations and the formation of new aerosol particles have been already observed, which can now be explained.

2023-08-11

·Coatings World

Induron Protective Coatings Launches New NOVALAC Epoxy

Induron Protective Coatings announces the launch of its newest product, Novasafe. Novasafe is a furfuryl modified, thick film, ceramic-filled novolac epoxy and it can stand up to the most extreme environments encountered in treatment plants. “Water and wastewater treatment plant owners, operators, and engineers are under more pressure than ever to protect our national water infrastructure,” said William Seawell, Induron technical service manager. “In a period of increased influent volume, more chemically extreme influent, and increasing regulatory pressure, there is an increasing need for longer immersion coating service lives. “For years, Induron’s method of choice for protecting buried ductile iron pipe interiors, water tank interiors and water treatment plant interiors has been thick film ceramic epoxy technology,” Seawell added. “In response to industry challenges, Induron is bringing that same technology to the most extreme service environments encountered in treatment plants with its introduction of Novasafe ceramic novolac.” Novasafe’s formulation chemistry is unique in the industry, and it is able to accomplish what treatment plant operators need in the most extreme environments with one less coat compared to traditional epoxies and less film thickness than polyurethane/polyurea. Novasafe is able to accomplish this with its unique resin and filler package. As a benchmark of performance, Novasafe is able to withstand exposure to sulfuric acid at all concentration ranges for extended periods of time. Many industry novolacs can withstand dilute or 98% sulfuric acid but the range of 93-97% has historically been problematic for un-baked novolac products— even in the oil and gas industries where this is a significant issue. “While Novasafe is not appropriate for all services—no lining material is— there is a place in every treatment plant specification or treatment plant where Novasafe can assist in providing long-term asset protection, reducing maintenance load, saving maintenance dollars and improving the look of the facility,” said Davies Hood, Induron president.

100 项与 Sodium Sulfate 相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D05877	-	A06AD13 A12CA02	DB09472

研发状态

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
ST段抬高心肌梗死	临床2期	-	Mallinckrodt Plc	2009-12-01
冠心病	临床2期	澳大利亚	Mallinckrodt Plc	2009-05-01
冠心病	临床2期	加拿大	Mallinckrodt Plc	2009-05-01
氧自由基损伤	临床2期	澳大利亚	Mallinckrodt Plc	2009-05-01
氧自由基损伤	临床2期	加拿大	Mallinckrodt Plc	2009-05-01
心肌梗塞	临床2期	-	Fred Hutchinson Cancer Research Center	-
心肌缺血	临床2期	澳大利亚	Ikaria, Inc.	-
心肌缺血	临床2期	加拿大	Ikaria, Inc.	-
再灌注损伤	临床2期	澳大利亚	Ikaria, Inc.	-
再灌注损伤	临床2期	加拿大	Ikaria, Inc.	-

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00995501 (CTgov)	N/A	炎症	381	Insulin+anesthesia management+Dexamethasone Sodium Sulfate (Intensive Glucose Control, Dexamethasone, Light Anesthesia)	憲範鏇蓋構齋襯獵襯觸(製淵築鏇構鬱網衊網壓) = 壓衊選獵糧鬱範觸糧衊觸蓋衊觸襯選窪範鹽淵 (築艱築糧憲鏇壓築齋範, 鬱壓鏇襯製網願獵廠鹽 ~ 鬱網繭憲壓窪獵構範窪) 更多	-	2017-04-25
				Anesthesia management -Placebo+Dexamethasone Sodium Sulfate (Intensive Glucose Control, Dexamethasone, Deep Anesthesia)	憲範鏇蓋構齋襯獵襯觸(製淵築鏇構鬱網衊網壓) = 夢構蓋艱網顧顧築衊範觸蓋衊觸襯選窪範鹽淵 (築艱築糧憲鏇壓築齋範, 窪壓衊齋構鹹構膚壓鹽 ~ 窪遞憲餘選醖築範窪齋) 更多
NCT00879645 (CTgov)	临床1期	肾功能不全	28	Sodium Sulfide (Sodium Sulfide - Mild Cohort)	鑰鬱齋簾廠鏇鹽積膚膚(夢繭繭鬱網積鹽鬱選製) = 膚蓋繭構鏇獵衊鑰夢獵簾積簾觸範範淵襯夢鹽 (製鏇糧願鹹艱襯觸壓襯, 範壓淵淵遞夢鏇鹽觸鏇 ~ 蓋艱艱醖艱範鏇廠齋蓋) 更多	-	2010-11-04
				Sodium Sulfide (Sodium Sulfide - Healthy Cohort)	鑰鬱齋簾廠鏇鹽積膚膚(夢繭繭鬱網積鹽鬱選製) = 窪齋構艱衊積鑰積齋餘簾積簾觸範範淵襯夢鹽 (製鏇糧願鹹艱襯觸壓襯, 齋鏇鬱製憲網餘壓膚築 ~ 構艱餘餘窪鏇壓餘膚餘) 更多