Evaluation of therapeutic effects of bacopa monnieri on neuropsychologic profile resulting from traumatic brain injury: a randomized, double-blind, placebo-controlled trial

开始日期2024-09-22

申办/合作机构-

CTRI/2024/06/069191 / Not yet recruiting临床3期IIT

Comparative Study on the Effectiveness of Bacopa monnieri Mother tincture and Individualized Homoeopathic medicine in Children with Scholastic Backwardness - NIL

开始日期2024-07-15

申办/合作机构-

100 项与假马齿苋提取物相关的临床结果

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100 项与假马齿苋提取物相关的转化医学

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100 项与假马齿苋提取物相关的专利（医药）

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129

项与假马齿苋提取物相关的文献（医药）

2024-11-01·Neurochemistry International

Bacopa monnieri confers neuroprotection by influencing signaling pathways associated with interleukin 4, 13 and extracellular matrix organization in Alzheimer's disease: A proteomics-based perspective

Article

作者: Amrutha, S. ; Pervaje, Ravishankar ; Keshava Prasad, Thottethodi Subrahmanya ; Prasad, Thottethodi Subrahmanya Keshava ; Najar, Mohd Altaf ; Modi, Prashant Kumar ; Palollathil, Akhina ; Amrutha, S

Alzheimer's disease, a prevalent neurodegenerative disorder in the elderly, is characterized by the accumulation of senile plaques and neurofibrillary tangles, triggering oxidative stress, neuroinflammation, and neuronal apoptosis. Current therapies focus on symptomatic treatment rather than targeting the underlying disease-modifying molecular mechanisms and are often associated with significant side effects. Bacopa monnieri, a traditional Indian herb with nootropic properties, has shown promise in neurological disorder treatment from ancient times. However, its mechanisms of action in Alzheimer's disease remain elusive. In this study, a cellular model for Alzheimer's disease was created by treating differentiated IMR-32 cells with beta-amyloid, 1-42 peptide (Aβ₄₂). Additionally, a recovery model was established through co-treatment with Bacopa monnieri to explore its protective mechanism. Co-treatment with Bacopa monnieri extract recovered Aβ₄₂ induced damage as evidenced by the decreased apoptosis and reduced reactive oxygen species production. Mass spectrometry-based quantitative proteomic analysis identified 21,674 peptides, corresponding to 3626 proteins from the Alzheimer's disease model. The proteins dysregulated by Aβ₄₂ were implicated in cellular functions, such as negative regulation of cell proliferation and microtubule cytoskeleton organization. The enriched pathways include extracellular matrix organization and interleukin-4 and interleukin-13 signaling. Bacopa monnieri co-treatment showed remarkable restoration of Aβ₄₂ altered proteins, including FOSL1, and TDO2. The protein-protein interaction network analysis of Bacopa monnieri restored proteins identified the hub gene involved in Alzheimer's disease. The findings from this study may open up new avenues for creating innovative therapeutic approaches for Alzheimer's disease.

2024-09-01·EXPLORE

Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial

Article

作者: Kordestani-Moghaddam, Parastou ; Delfan, Maryam ; Kazemi, Khadije ; Mohammadi, Rasool ; Gholami, Mohammad

INTRODUCTIONMild cognitive impairment is the middle level of natural cognitive impairment during primary steps of dementia. There are a few studies about improving the cognitive performance and sleep quality in patients with a limited dementia. So, this study was conducted to evaluate the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment.MATERIALS AND METHODSIn this study, 62 patients with mild cognitive impairment were categorized into two groups of control and intervention. The intervention group received one pill of 160 mg Bacopa monnieri extract in 2 months, and the control group received a pill containing starch powder. The cognitive impairment and sleep quality was assessed using a questionnaire containing demographic information, Montreal Cognitive Assessment, and the Pittsburg Sleep Quality Index in three time-points of before the study, one months after the intervention and 2 months after the intervention (the end of study).RESULTSThe results showed no statistically significant difference between two groups in all three time-points in overall cognitive performance score and its 6 parameters (P > 0.05). While in the field of attention at the end of the first month (P = 0.033) and the end of the second month (P = 0.004), it was significant difference between the study groups. Also, in the field of verbal fluency at the end of the second month, this difference was significant (P = 0.003). The cognitive performance overall score showed no significant difference between two groups in first (P = 0.939) and second time-points (P = 0.661), although it was significant at third time-point (P = 0.029). There was no statistically significant difference between two groups in all time-points for sleep quality overall score (P > 0.05).CONCLUSIONThe results showed that Bacopa monnieri can improve the cognitive performance overall score and some of its parameters, but it had no effect on sleep quality.

2024-07-01·Molecular Nutrition & Food Research

Amelioration of Amyloid‐β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK‐3β/Wnt/β‐Catenin Signaling

Article

作者: Sahu, Manas Ranjan ; Murugan, Natarajan Arul ; Mondal, Amal Chandra ; Sushma

BackgroundAlzheimer's disease (AD) is the most prevalent dementia, affecting a large number of populations. Despite being under scrutiny for decades, an effective therapeutic option is still not available.Methods and resultsThis study explores the therapeutic role of a nootropic herb Bacopa monnieri (BM) in AD‐like pathological conditions produced by injecting preformed amyloid‐β42 (Aβ42) fibril bilaterally into hippocampus of Wistar rats, and ethanolic extract of BM is orally administered for 4 weeks. Assessment of behavioral changes reveals that BM treatment ameliorates Aβ42‐induced cognitive impairment and compromised explorative behavior. Supplementation of BM also reduces oxidative stress biomarkers, proinflammatory cytokines, and cholinesterase activity in the AD rats. Additionally, BM treatment restores Bcl‐2‐associated X protein (Bax)/ B‐cell lymphoma 2 (Bcl‐2) imbalance, increases neurotrophic factors expression, and prevents neurodegeneration validated by quantifying Nissl‐positive hippocampal neurons. Interestingly, BM administration eliminates amyloid plaques in the hippocampal region and normalizes the Aβ42‐induced increase in phospho‐tau and total tau expression. Mechanistic investigations reveal that BM interacts with glycogen synthase kinase (GSK‐3β) and restores Wnt/β‐catenin signaling.ConclusionBM has been used in diet as a nootropic herb for several centuries. This study highlights the anti‐Alzheimer activity of BM from the behavioral to the molecular level by modulating mitochondrial dysfunction, and GSK‐3β mediates the Wnt/β‐catenin signaling pathway.

项与假马齿苋提取物相关的新闻（医药）

2021-03-02

·GlobeNewswire

Cognetics EXCEL -- Super-Food for the Brain and Mind -- Will Debut at ECRM’s Retail Buyers/Brands Confab

PALM BEACH, FL, March 02, 2021 (GLOBE NEWSWIRE) -- Cognetics EXCEL, a multi-faceted nootropic for the brain and mind, will make its debut in front of more than 50 top buyers from large and small retail chains in the United States in March. “Our representatives will introduce Cognetics EXCEL at ECRM's Healthy Living, Vitamin, and Nutrition Program" in March,” said Matthew Denneny, managing director and founder of Cognetics Group based in London. “ECRM offers us a great opportunity to showcase Cognetics EXCEL, a super-food for the brain, to buyers from the top retail outlets in the country.” ECRM, an acronym for Efficient Collaborative Retail Marketing, is the retail industry’s version of speed dating, which brings buyers and new brands and products together for private one-on-one meetings. ECRM hosts these virtual events by using an innovative digital platform for face-to-face meetings between buyers and sellers. Buyers attending the ECRM event will represent regional and national food, drug and mass health chains. Cognetics EXCEL brain supplement is for anyone dealing with lack of focus or motivation, brain fog, poor memory, and decreased productivity. Denneny said the popular Cognetics EXCEL in the UK is now available to American consumers at online retailers, such as OneLavi.com and VitaBeauti.co, both health and wellness websites. “We are looking forward to the feedback we get from the retail buyers,” Denneny said. “Cognetics EXCEL is a nootropic for the mind that is perfect for workers, parents, and students who need assistance focusing.” As a health and wellness company, the Cognetics Group believes consumers have a right to know what is in the supplements they take, which is why Cognetics EXCEL’s label outlines all of its ingredients and the amount of each ingredient in each dose. The formula includes nine powerful and effective natural ingredients, such as Lion’s Mane Mushroom, Choline Bitartrate, N-Acetyl Carnitine, Tyrosine, Theanine, Bacopa Monnieri, Ginkgo Biloba Extract, Huperzine A, and Rhodiola Rosea. “We only included ingredients backed by clinical studies to enhance focus, productivity, and memory,” he added. In addition to developing Cognetics EXCEL, the Cognetics Group is dedicated to helping people who struggle with mental health conditions, which is why it donates $1 from every purchase to non-profit organizations assisting people with these conditions. “The ECRM event provides us with a great platform to showcase and promote Cognetics EXCEL, an innovative nootropic that can help millions of people,” Denneny said. For more information, visit OneLavi.com, VitaBeauti.com or Cogneticsgroup.com. Attachments Cognetics EXCEL Cognetics EXCEL Nootropic Robert Grant Cognetics Group LTD 561-421-3045 pr@nutrapr.com

100 项与假马齿苋提取物相关的药物交易

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


MDS2021	N/A	-	50	Bacopa monnieri	醖鏇夢醖糧鏇築鹽衊選(夢膚餘淵網糧蓋獵蓋襯) = 夢獵範淵膚齋選餘構簾窪繭襯製鬱遞糧範餘簾 (積鏇觸餘衊鏇遞觸餘襯 )	积极	2021-09-17