1998-09-01·Bioorganic & Medicinal Chemistry3区 · 医学
Endothelin receptor antagonists: synthesis and structure–activity relationships of substituted benzothiazine-1,1-dioxides
3区 · 医学
Article
作者: S. J. Haleen ; Kathy M. Welch ; Annette Marian Doherty ; Jeremy J. Edmunds ; Amy Mae Bunker ; J. Bryant ; Kent Alan Berryman
The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure-activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ETA receptor subtype.