更新于：2024-11-21

Selenomethionine Se-75

更新于：2024-11-21

概要

研发状态

概要

基本信息

药物类型

化学药、诊断用放射药物

别名

Sethotope

靶点-

作用机制

PET imaging(正电子发射断层成像术增强剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构

Bracco Diagnostics, Inc.

在研机构-

非在研机构

Pharmalucence, Inc.Bracco Diagnostics, Inc.GE Healthcare Holdings, Inc.

+ [1]

最高研发阶段撤市

首次获批日期

美国 (1973-05-07)

最高研发阶段(中国)-

特殊审评-

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结构

分子式C5H11NO2Se

InChIKeyRJFAYQIBOAGBLC-ZEMBQCNESA-N

CAS号1187-56-0

关联

100 项与 Selenomethionine Se-75 相关的临床结果

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100 项与 Selenomethionine Se-75 相关的转化医学

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100 项与 Selenomethionine Se-75 相关的专利（医药）

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项与 Selenomethionine Se-75 相关的文献（医药）

2024-10-01·Journal of Cellular and Molecular Medicine

The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism

Article

作者: Gao, Fei ; Xu, Qing‐Yang ; Wang, Wen‐Yan ; Chen, Zhao‐Yang ; Wu, Ke‐Jia ; Chen, Qi ; Leung, Chung‐Hang ; Sun, Ning ; Zhu, Xing‐Yu ; Dai, Yan‐Fa

AbstractPathological cardiac hypertrophy, a common feature in various cardiovascular diseases, can be more effectively managed through combination therapies using natural compounds. Harmine, a β‐carboline alkaloid found in plants, possesses numerous pharmacological functions, including alleviating cardiac hypertrophy. Similarly, Selenomethionine (SE), a primary organic selenium source, has been shown to mitigate cardiac autophagy and alleviate injury. To explores the therapeutic potential of combining Harmine with SE to treat cardiac hypertrophy. The synergistic effects of SE and harmine against cardiac hypertrophy were assessed in vitro with angiotensin II (AngII)‐induced hypertrophy and in vivo using a Myh6R404Q mouse model. Co‐administration of SE and harmine significantly reduced hypertrophy‐related markers, outperforming monotherapies. Transcriptomic and metabolic profiling revealed substantial alterations in key metabolic and signalling pathways, particularly those involved in energy metabolism. Notably, the combination therapy led to a marked reduction in the activity of key glycolytic enzymes. Importantly, the addition of the glycolysis inhibitor 2‐deoxy‐D‐glucose (2‐DG) did not further potentiate these effects, suggesting that the antihypertrophic action is predominantly mediated through glycolytic inhibition. These findings highlight the potential of SE and harmine as a promising combination therapy for the treatment of cardiac hypertrophy.

2021-12-01·Biological Trace Element Research3区 · 生物学

Effects of Supplementary Selenium and Vitamin E on the Growth Performance, Antioxidant Enzyme Activity, and Gene Expression of Sea Cucumber Apostichopus japonicus

3区 · 生物学

Article

作者: Gao, Qinfeng ; Li, Xueqi ; Xu, Yuling ; Mei, Yaoping ; Dong, Shuanglin

A 60-day feeding experiment was conducted to evaluate the effects of single selenomethionine (Se) and its mixture with vitamin E (VE) on the growth, antioxidant enzyme activities, and gene expression of juvenile sea cucumber Apostichopus japonicus. The design of the experiment contained two factors and 5 × 2 levels by means of adding various levels of Se and VE in the feed, i.e., combination of 0, 0.3, 0.6, 0.9, or 1.2 mg Se kg^-1 and 0 or 200 mg VE kg^-1. The results revealed that the specific growth rate and weight gain rate were the highest in the group with 0.3 mg Se kg^-1 and 200 mg VE kg^-1, followed by the group with 0.6 mg Se kg^-1 without VE. Se significantly improved the activities of amylase and protease with VE also imposed positive effect on the amylase activity. Glutathione peroxidase (GPX) activity was highest in the group with 1.2 mg Se kg^-1 and lowest with the basal diet. The activity of catalase (CAT) was increased while glutathione reductase (GR) activity was decreased in response to the addition of Se. No significant interactive effects of Se and VE on the enzyme activities were found except superoxide dismutase (SOD) activity. While relative expressions of GPX, CAT, and SOD genes were significantly responsive to the addition of dietary Se, VE significantly promoted the gene expression of SOD. The results suggested that Se and VE might have beneficial effects on the growth and antioxidant responses of A. japonicus.

2018-12-01·Reviews in Endocrine and Metabolic Disorders2区 · 医学

The protective effect of myo-inositol on human thyrocytes

2区 · 医学

Article

作者: Ragusa, Francesca ; Ferrari, Silvia Martina ; Fallahi, Poupak ; Antonelli, Alessandro ; Caruso, Claudia ; Elia, Giusy ; Paparo, Sabrina Rosaria ; Benvenga, Salvatore

Patients affected by autoimmune thyroiditis reached positive effects on indices of thyroid autoimmunity and/or thyroidal function, after following a treatment with selenomethionine (Se) alone, or Se in combination with Myo-inositol (Myo-Ins). Our purpose was to investigate if Myo-Ins alone, or a combination of Se + Myo-Ins, is effective in protecting thyroid cells from the effects given by cytokines, or hydrogen peroxide (H₂O₂). We assessed the interferon (IFN)-γ-inducible protein 10 (IP-10/CXCL10) secretion by stimulating primary thyrocytes (obtained from Hashimoto's thyroiditis or from control patients) with cytokines in presence/absence of H₂O_2. Our results confirm: 1) the toxic effect of H₂O₂ in primary thyrocytes that leads to an increase of the apoptosis, to a decrease of the proliferation, and to a slight reduction of cytokines-induced CXCL10 secretion; 2) the secretion of CXCL10 chemokine induced by IFN-γ + tumor necrosis factor alpha (TNF)-α has been decreased by Myo + Ins, both in presence or absence of H₂O₂; 3) no effect has been shown by the treatment with Se. Therefore, a protective effect of Myo-Ins on thyroid cells has been suggested by our data, which exact mechanisms are at the basis of this effect need to be furtherly investigated.

100 项与 Selenomethionine Se-75 相关的药物交易

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