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更新于：2025-03-20

Selenomethionine Se-75

更新于：2025-03-20

概要

概要

基本信息

药物类型

化学药、诊断用放射药物

别名

Sethotope

靶点-

作用方式

增强剂

作用机制

PET imaging(正电子发射断层成像术增强剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构

Bracco Diagnostics, Inc.

在研机构-

非在研机构

Pharmalucence, Inc.Bracco Diagnostics, Inc.GE Healthcare Holdings, Inc.

+ [1]

最高研发阶段撤市

首次获批日期

美国 (1973-05-07)

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C5H11NO2Se

InChIKeyRJFAYQIBOAGBLC-ZEMBQCNESA-N

CAS号1187-56-0

关联

100 项与 Selenomethionine Se-75 相关的临床结果

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100 项与 Selenomethionine Se-75 相关的转化医学

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100 项与 Selenomethionine Se-75 相关的专利（医药）

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项与 Selenomethionine Se-75 相关的文献（医药）

2014-02-14·British Journal of Nutrition3区 · 医学

Gamma camera imaging for studying intestinal absorption and whole-body distribution of selenomethionine

3区 · 医学

Article

作者: Fuglsang, Stefan ; Ljungberg, Michael ; Rasmussen, Palle ; Sjögreen-Gleisner, Katarina ; Madsen, Jan L ; Damgaard, Morten ; Elema, Dennis R ; Søndergaard, Lasse R

Se metabolism in humans is not well characterised. Currently, the estimates of Se absorption, whole-body retention and excretion are being obtained from balance and tracer studies. In the present study, we used gamma camera imaging to evaluate the whole-body retention and distribution of radiolabelled selenomethionine (SeMet), the predominant form of Se present in foods. A total of eight healthy young men participated in the study. After consumption of a meal containing 4 MBq [75Se]l-SeMet ([75Se]SeMet), whole-body gamma camera scanning was performed for 45 min every hour over a 6 h period, every second hour for the next 18 h and once on each of the subsequent 6 d. Blood, urine and faecal samples were collected to determine the plasma content of [75Se]SeMet as well as its excretion in urine and faeces. Imaging showed that 87·9 (sd 3·3) % of the administered activity of [75Se]SeMet was retained within the body after 7 d. In contrast, the measured excretion in urine and faeces for the 7 d period was 8·2 (sd 1·1) % of the activity. Time–activity curves were generated for the whole body, stomach, liver, abdomen (other than the stomach and the liver), brain and femoral muscles. Gamma camera imaging allows for the assessment of the postprandial absorption of SeMet. This technique may also permit concurrent studies of organ turnover of SeMet.

2000-04-01·Applied Radiation and Isotopes3区 · 工程技术

Generic models for radionuclide dosimetry: 11C-, 18F- or 75Se-labelled amino acids

3区 · 工程技术

Article

作者: Taylor, D M

A generic biokinetic model was developed for use in the assessment of the internal dose received by human subjects injected with amino acids labelled with 11C (T1/2 = 0.34 h, beta+, gamma), 18F(T1/2 = 1.83 h, beta+, gamma) or 75Se (T1/2 = 119.8 d, beta-, gamma). This generic model was used in conjunction with the MIRDOSE 3 computer programme to calculate radiation doses to adults; these radiation doses were compared with those calculated using compound-specific models for two [11C]-, and eight [18F]-labelled amino acids and [75Se]selenomethionine. In general, the effective doses, as well as the organ and tissue doses, calculated using the generic model agreed within a factor of 2 or less, with those calculated using compound-specific models; the generic model tended to over-, rather than underestimate the organ and tissue doses. It was concluded that for 11C- and 18F-labelled amino acids and for 75Se-labelled amino acids or their analogues, the single generic biokinetic model could be applied for general radiation protection purposes.

1995-05-01·Nuclear Medicine and Biology4区 · 医学

Evaluation of radioselenium labeled selenomethionine, a potential tracer for brain protein synthesis by PET

4区 · 医学

Article

作者: Peter Brust ; Heinz H. Coenen ; Ralf Bergmann ; Gerhard Stöcklin ; Gudrun Kampf

The blood-brain transfer, protein incorporation and metabolism of L-[75Se]selenomethionine (SeMet) of relatively high specific activity (> 400 GBq mmol) were studied in male Wistar rats. The highest uptake was found in the pancreas, followed by the tumor, kidney, liver, brain and muscle. In addition, plasma and brain samples of rats were analyzed for labeled fractions of free SeMet, metabolites, and SeMet bound to t-RNA and proteins. For example, free SeMet represented more than 80% of brain radioactivity at 1.5 min while it was less than 15% at 360 min. A concomitant increase was observed for protein bound SeMet in brain. A three-compartment model was applied to calculate the blood-brain transfer constant (K1 (0.15 +/- 0.070 mL g-1 min-1) and the rate constant of SeMet incorporation into proteins (k3 = 0.026 +/- 0.008 min-1). The apparent incorporation of methionine into proteins was estimated to be about 0.73 nmol g-1 min-1. From the studies it is concluded that the use of L-[75Se]selenomethionine may be appropriate to measure brain protein incorporation in humans with PET.

100 项与 Selenomethionine Se-75 相关的药物交易

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