YM-11124(YM-11124) - 在研适应症：过敏_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点-

作用机制

免疫抑制剂

治疗领域

免疫系统疾病

在研适应症

过敏

非在研适应症-

原研机构

Yamanouchi Pharmaceutical Co., Ltd.

在研机构

Yamanouchi Pharmaceutical Co., Ltd.

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C15H10N2OS

InChIKeyDPGKZDHSXINFBS-UHFFFAOYSA-N

CAS号79889-39-7

关联

100 项与 YM-11124 相关的临床结果

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100 项与 YM-11124 相关的转化医学

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100 项与 YM-11124 相关的专利（医药）

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1

项与 YM-11124 相关的文献（医药）

1989-01-01·Pharmacology4区 · 医学

Pharmacological Properties of YM-11124, a Selective Immunosuppressive Agent for Cell-Mediated Immunity

4区 · 医学

Article

作者: Yamada, Toshimitsu ; Mase, Toshiyasu ; Murase, Kiyoshi ; Tomioka, Kenichi

Effect of YM-11124 on cell-mediated immune responses, type I to type III allergic reactions and inflammatory reaction was determined in mice, rats and guinea pigs. YM-11124 inhibited picryl chloride- and methylated bovine serum albumin-induced delayed-type hypersensitivity reactions by the treatment during both the sensitization and the elicitation phases in mice. Bilateral adrenalectomy did not prevent the suppression of DTH response by YM-11124. YM-11124 significantly prolonged the survival time of allogenic skin grafts in mice. Furthermore, YM-11124 inhibited the passive Arthus reaction in guinea pigs and the reversed passive Arthus reaction in rats. However, YM-11124 did not affect the passive cutaneous anaphylaxis reaction in rats, Forssman shock in guinea pigs and paw edema in rats. These results indicate that YM-11124 suppresses not only cell-mediated immune responses (type IV allergic reactions) but also type III allergic reactions without influence on types I and II allergic reactions as well as acute inflammation.

100 项与 YM-11124 相关的药物交易

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