预约演示

更新于：2025-05-07

4-Dimethylamino chalcone

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

DMAC

靶点-

作用方式-

作用机制-

治疗领域

神经系统疾病其他疾病

在研适应症

镇痛

非在研适应症-

原研机构-

在研机构

Federal University of Rio de Janeiro

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C17H17NO

InChIKeyPDKPRWFMRVBCOB-UHFFFAOYSA-N

CAS号1030-27-9

关联

100 项与 4-Dimethylamino chalcone 相关的临床结果

登录后查看更多信息

100 项与 4-Dimethylamino chalcone 相关的转化医学

登录后查看更多信息

100 项与 4-Dimethylamino chalcone 相关的专利（医药）

登录后查看更多信息

599

项与 4-Dimethylamino chalcone 相关的文献（医药）

2025-06-01·Environmental Pollution

Synergistic enhancement of hydrophobic n-hexane biodegradation in a biotrickling filter: Role of hydrophilic VOCs in mass transfer and extracellular polymeric secretion

Article

作者: Liu, Lingxiu ; Chen, Jun ; Ye, Dongyun ; Hrynsphan, Dzmitry ; Wang, Zeyu ; Fan, Hongye ; Weng, Xiaole ; Tatsiana, Savitskaya

Volatile organic compounds (VOCs) emitted from the pharmaceutical industry, such as n-hexane, dichloromethane (DCM), and N, N-dimethylacetamide (DMAC), pose significant environmental and health risks. This study evaluates the performance of a bamboo charcoal-based bio-trickling filter (BTF) in removing these VOCs, comparing two systems: BTF-a, treating only n-hexane, and BTF-b, treating a mixture of n-hexane, DCM, and DMAC. After 26 days of operation at an n-hexane concentration of 100 mg·m^-3, BTF-b achieved a removal efficiency (RE) of 87.25% for n-hexane, significantly higher than the 62% in BTF-a, showcasing the synergistic effects of multi-component VOCs. As the DMAC concentration increased from 100 mg·L^-1 to 500 mg·L^-1, the RE of n-hexane improved from 65.93% to 82.08%, with a significant enhancement in the mass transfer coefficient (K_La) from 1.75×10^-6 to 6.34×1^-5 s^-1, demonstrating the positive promotional effect of DMAC on n-hexane biodegradation. Conversely, high DCM concentrations (750 mg·m^-3) reduced the RE of n-hexane to 58.57% due to substrate competition. The extracellular proteins (PN) content rose from 16.76 mg·g^-1 to 18.73 mg·g^-1. Microbial analysis after 220d operation revealed the enrichment of Mycobacterium (57.67%) and Hyphomicrobium (5.38%), key genera involved in VOCs biodegradation. Metabolic pathway analysis showed n-hexane and DMAC were transformed into intermediates, including hexanoic acid and acetic acid, demonstrating both pollutant removal and resource recovery potential. These findings highlight the synergistic role of hydrophilic VOCs, which are more hydrophilic than n-hexane, in promoting the biodegradation of hydrophobic pollutants, as well as the feasibility of BTF for treating multi-component VOCs.

2025-06-01·Carbohydrate Polymers

Dissolving limitations: The power of DMSO activation for cellulose SEC analysis

Article

作者: Potthast, Antje ; Rosenau, Thomas ; Melikhov, Ivan ; Bacher, Markus ; Schiehser, Sonja ; Sulaeva, Irina ; Kostić, Mirjana

The molar mass distribution is a crucial parameter for cellulose samples used in both research and industry, typically determined by size-exclusion chromatography (SEC) coupled with multi-angle laser light scattering and refractive index detection (MALLS-RI). While DMSO activation has been proven effective for dissolving challenging samples, such as regenerated fibers, in 9 % (w/v) DMAc/LiCl, the structural changes occurring during this activation are not yet fully understood. To address this, we analysed the effects of the DMSO activation on man-made fibers (Lyocell, Viscose, Modal) and microcrystalline cellulose over varying durations (30 min, 1 d, and 7 d), compared to conventional activation with DMAc for 7 d. The DMSO activation did not only influence the crystallinity index and hemicellulose content but also altered the dissolution behavior of regenerated cellulose fibers. Moreover, the DMSO activation step facilitated the dissolution of low-molar-mass fractions in 0.9 % (w/v) DMAc/LiCl. Importantly, the DMSO activation protocol was optimized to prevent the potential loss of low-molar-mass fractions for hemicellulose-rich samples. The altered (dn/dc)_μ value was determined and applied to ensure accurate data analysis.

2025-05-01·Journal of Infection and Public Health

Two-drug versus three-drug regimens for treating Mycobacterium avium complex infection: A systematic review and meta-analysis

Review

作者: Nguyen, Van-Dong ; Lee, Ming-Chia ; Lin, Jung-Chun ; Duong, Hai ; Chen, Hsiao-En ; Wang, Jann-Yuan ; Lee, Chih-Hsin ; Chen, Jin-Hua ; Huang, Wei-Chang

BACKGROUNDMycobacterium avium complex (MAC) infection, requiring prolonged treatment with an antibiotic combination, is an emerging public health concern.METHODSThis meta-analysis compared the efficacy of 2-drug regimens with that of 3-drug regimens in bacteriological responses, acquired macrolide resistance (AMR), and mortality among adult patients with disseminated MAC infection (DMAC) and MAC pulmonary disease (MAC-PD).RESULTSSeven randomized controlled trials (RCTs) and 3 non-RCT studies, encompassing 1369 patients, were included. Treating DMAC with 2-drug regimens was associated with comparable bacteriological responses (odds ratio (OR) = 0.76, 95 % confidence interval (CI) = 0.48-1.18, P = .22) and mortality (OR = 1.29, 95 % CI = 0.59-2.83, P = .52), but had a higher risk of AMR (OR = 2.99, 95 % CI = 1.10-8.13, P = .03). For MAC-PD, 2-drug regimens were noninferior to 3-drug regimens in bacteriological responses (OR = 0.82, 95 % CI = 0.53-1.25, P = .35) and AMR (risk differences (RD) = 0.01, -0.02 to 0.05, P = .39), with no observed mortalities. Although not statistically significant compared to the 3-drug regimen, the macrolide-rifamycin regimen resulted in attenuated bacteriological responses (OR = 0.51, 95 % CI = 0.14-1.90, P = .32). However, the proportion of patients with bacteriological response (OR = 1.54, 95 % CI = 0.78-2.93, P = .23) and AMR risk (RD = 0.01, -0.02 to 0.04, P = .50) was not different between those under the macrolide-ethambutol regimen and those under 3-drug regimens.CONCLUSIONSThe macrolide-ethambutol 2-drug regimen may be a viable alternative option for treating MAC-PD, whereas DMAC can be preferably managed with a 3-drug regimen.

项与 4-Dimethylamino chalcone 相关的新闻（医药）

2017-11-05

·BioPortfolio

Global NDimethylacetamide Market Research Report 20112023 [Report Updated: 23102017] Prices from USD $2480

Summary NDimethylacetamide DMAC is a colorless, high boiling, polar, hygroscopic liquid. DMAC is a good solvent for a wide range of organic and inorganic compounds and it is miscible with water, ethers, esters, ketones and aromatics compounds. It is used in the production of polyacrylonitrile and polyurethane based fibers, films and coatings. The polar nature of DMAC enables it to act as a combined solvent and reaction catalyst in many reactions producing high yields and pure product in short time periods. The global NDimethylacetamide market will reach xxx Million USD in 2017 with CAGR xx% 20182023. The objective of report is to define, segment, and project the market on the basis of product type, application, and region, and to describe the content about the factors influencing market dynamics, policy, economic, technology and market entry etc. Based on products type, the report describes major products type share of regional market. Products mentioned as follows: Pharmaceutical Grade Industrial Grade Leading vendors in the market are included based on profile, business performance etc. Vendors mentioned as follows: Dupont Zhejiang Jiangshan Chemical Shandong Jinmei Riyue Industry BASF Shanghai Jinshan Jingwei Te An Ling Tian Fine Chemical Eastman MGC Huaxu Huagong Akkim Samsung Based on Application, the report describes major application share of regional market. Application mentioned as follows: Pharmaceutical Industry Fiber Industry Plastic Industry Cosmetic Industry Organic Synthesis Others Based on region, the report describes major regions market by products and application. Regions mentioned as follows: AsiaPacific North America Europe South America Middle East Africa

100 项与 4-Dimethylamino chalcone 相关的药物交易

登录后查看更多信息