Zamtocabtagene autoleucel(Zamtocabtagene autoleucel) - 药物靶点：CD19 x CD20_在研适应症：Carney复合症，难治性成熟B细胞非霍奇金淋巴瘤，弥漫性大B细胞淋巴瘤_专利_临床

概要

基本信息

药物类型

自体CAR-T

别名

Anti-CD20-anti-CD19 CAR T cells、CD20-CD19-targeting CAR T Cells、DALY II USA

+ [2]

靶点

CD19 x CD20

作用方式

抑制剂

作用机制

CD19抑制剂(B淋巴细胞抗原CD19抑制剂)、CD20抑制剂(B淋巴细胞抗原CD20抑制剂)、T淋巴细胞替代物

治疗领域

肿瘤免疫系统疾病心血管疾病+ [6]

在研适应症

Carney复合症难治性成熟B细胞非霍奇金淋巴瘤弥漫性大B细胞淋巴瘤+ [15]

非在研适应症-

原研机构

Miltenyi Biomedicine GmbH

在研机构

Miltenyi Biomedicine GmbH

National Institute For Health & Care Research

Miltenyi Biotec BV & Co. KG

非在研机构-

权益机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

Sequence Code 1277314408

关联

8

项与 Zamtocabtagene autoleucel 相关的临床试验

NCT07178431

/ Not yet recruiting临床1/2期

An Open Label Phase I/IIa, Multicenter, Interventional Single-arm Trial of MB-CART 2019.1 in Patients With Refractory Multiple Sclerosis (MS)

The goal of this trial is to assess the feasibility, safety and preliminary efficacy of MB-CART2019.1 in patients with active refractory primary and secondary progressive MS.

开始日期2026-01-30

申办/合作机构

Miltenyi Biomedicine GmbH

CTIS2024-517601-82-00

/ Not yet recruiting临床1/2期

MB-CART2019.1 in refractory MS

开始日期2025-12-11

申办/合作机构

Miltenyi Biomedicine GmbH

NCT07288879

/ Not yet recruiting临床2期

A Multi-center Single Arm Phase II Study to Evaluate the Safety and Efficacy of Genetically Engineered Autologous Cells Expressing Anti-CD20 and Anti-CD19 Specific Chimeric Antigen Receptor in Subjects With Relapsed and/or Refractory Diffuse Large B Cell Lymphoma.

DALY II Japan is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL) after receiving at least two lines of therapy.

开始日期2025-12-10

申办/合作机构

Miltenyi Biomedicine GmbH

100 项与 Zamtocabtagene autoleucel 相关的临床结果

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100 项与 Zamtocabtagene autoleucel 相关的转化医学

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100 项与 Zamtocabtagene autoleucel 相关的专利（医药）

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1

项与 Zamtocabtagene autoleucel 相关的文献（医药）

2024-10-01·RMD Open

Sustained drug-free remission in rheumatoid arthritis associated with diffuse large B-cell lymphoma following tandem CD20-CD19-directed non-cryopreserved CAR-T cell therapy using zamtocabtagene autoleucel

Article

作者: Heteren, Pearl van ; Nagy, György ; Gopcsa, Laszlo ; Balogh, Alexandra ; Zadoyan, Gregor ; Giba-Kiss, Laura ; Takacs, Peter ; Reti, Marienn ; Remenyi, Peter ; Paksi, Melinda ; Miltenyi, Stefan ; Lakatos, Gergely ; Overstijns, Toon ; Holtkamp, Silke ; Szabo, David

We report the case of long-term persisting rheumatoid arthritis (RA), treated with CD20-CD19 CAR-T when it became associated with diffuse large B cell lymphoma (DLBCL), resulting in a sustained drug-free remission of the preceding RA, as well as of the subsequent DLBCL that formed the indication of the CAR-T therapy using zamtocabtagene autoleucel, with a 1-year follow-up. According to our best knowledge, this is the first published clinical case report of long-term persisting RA treated with CAR-T cell therapy.

100 项与 Zamtocabtagene autoleucel 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
原发性进行性多发性硬化	临床2期	德国	Miltenyi Biomedicine GmbH	2026-01-30
Carney复合症	临床2期	日本	Miltenyi Biomedicine GmbH	2025-12-10
难治性成熟B细胞非霍奇金淋巴瘤	临床2期	法国	Miltenyi Biomedicine GmbH	2025-08-04
弥漫性大B细胞淋巴瘤	临床2期	奥地利	Miltenyi Biomedicine GmbH	2021-08-18
弥漫性大B细胞淋巴瘤	临床2期	比利时	Miltenyi Biomedicine GmbH	2021-08-18
弥漫性大B细胞淋巴瘤	临床2期	克罗地亚	Miltenyi Biomedicine GmbH	2021-08-18
弥漫性大B细胞淋巴瘤	临床2期	捷克	Miltenyi Biomedicine GmbH	2021-08-18
弥漫性大B细胞淋巴瘤	临床2期	芬兰	Miltenyi Biomedicine GmbH	2021-08-18
弥漫性大B细胞淋巴瘤	临床2期	法国	Miltenyi Biomedicine GmbH	2021-08-18
弥漫性大B细胞淋巴瘤	临床2期	德国	Miltenyi Biomedicine GmbH	2021-08-18

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASH2024	N/A	弥漫性大B细胞淋巴瘤	-	Zamto-cel	願淵窪窪膚醖壓壓鹹觸(積艱築構繭製獵鹹獵鹹) = 32 pts (46.4%) experienced cytokine release syndrome (CRS), all grade 1-2 衊顧艱製網築鹹蓋齋觸 (鹽觸齋顧鏇簾廠獵夢範 ) 更多	-	2024-12-07
DALY-II-USA (EHA2023)	N/A	弥漫性大B细胞淋巴瘤	28	zamtocabtagene autoleucel	構鹽憲繭範鏇衊製鑰鬱(壓築艱簾淵鑰襯鬱範糧) = 鏇齋選築廠壓鬱淵顧繭構膚鹽糧鹹築壓憲鏇鹽 (蓋顧淵願簾窪構糧鑰製 ) 更多	-	2023-06-08
NCT04792489 (DALY II USA, Tandem Meetings ASTCT and CIBMTR2023)	临床2期	难治性弥漫性大 B 细胞淋巴瘤 \| 复发性弥漫性大B细胞淋巴瘤 CD20 \| CD19+	27	Zamtocabtagene Autoleucel (zamto-cel)	遞鹹窪齋選壓艱積淵繭(蓋選獵衊簾鏇齋壓艱膚) = 選壓鏇積構獵餘艱積繭顧衊鹽網鏇齋選壓壓鑰 (鹽窪顧遞壓鹽鏇鬱膚鹽 ) 更多	积极	2023-02-01
NCT03870945 (ASH 12020 \| ASH 22020) 人工标引	临床1期	B细胞淋巴瘤 CD19 Positive \| CD20 Positive	12	MB-CART2019.1	鑰窪憲繭獵齋夢糧繭製(憲願鏇積膚膚餘糧餘網) = CRS grade 1 occurred in 3/6 patients on DL1 and DL2 each, and CRS grade 2 in 2 patients on DL2. 願構繭膚網憲憲鏇窪顧 (網獵鏇製夢鑰繭蓋鑰鑰 ) 更多	积极	2020-11-05
NCT03870945 (ASH 12020 \| ASH 22020) 人工标引	临床1期	B细胞淋巴瘤 CD19 Positive \| CD20 Positive	12	MB-CART2019.1		积极	2020-11-05