A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose Ranging Study to Evaluate the Efficacy and Safety of Prosaptide Over 6 Weeks of Treatment for the Relief of Neuropathic Pain Associated With HIV-1

This is a double-blind, placebo-controlled, parallel groups study to determine whether prosptide is effective in relieving pain in patients who have sensory neuropathic pain related to their HIV infection or the drugs used to treat it.

开始日期2003-09-01

申办/合作机构

Savient Pharmaceuticals, Inc.

100 项与 Prosaptide TX14 A 相关的临床结果

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100 项与 Prosaptide TX14 A 相关的转化医学

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100 项与 Prosaptide TX14 A 相关的专利（医药）

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104

项与 Prosaptide TX14 A 相关的文献（医药）

2024-11-01·Biomedicine & Pharmacotherapy

Dissecting the roles of prosaposin as an emerging therapeutic target for tumors and its underlying mechanisms

Review

作者: Yang, Chunjiao ; Wen, Zhenpeng ; Yan, Lirong ; Li, Yanke ; Li, Fang ; Zhang, Ye ; Yang, Yi ; Zhang, Yuzhe ; Liu, Aoran

As a dual-function protein, prosaposin (PSAP) is a lysosome-associated protein that participates in a variety of cellular processes. In the lysosome, PSAP is processed to activate enzymes that degrade lipids. In addition, PSAP proteins located extracellularly are involved in cancer progression, such as proliferation and tumor death suppression signaling. Moreover, under different situations, PSAP exhibits distinct metastasis potentials in tumors. However, comprehensive insight into PSAP in cancer progression has been lacking. Here, we provide a framework of the role of PSAP in cancer and its clinical application in cancer patients, providing a novel perspective on the clinical translation of PSAP.

2024-09-01·Ecotoxicology and Environmental Safety

Ambient air pollution decreased normal fertilization rate via the mediation of seminal prosaposin

Article

作者: Chen, Kaijie ; Jiang, Xiaoming ; Liu, Zhenfang ; Gao, Peng ; Cai, Jiali ; Liu, Lanlan ; Pan, Luxiang ; Ren, Jianzhi

OBJECTIVEThis study focuses on the association between seminal concentration of prosaposin and ambient air pollutants and whether the association affects the normal fertilization rate in vitro fertilization (IVF) treatment.METHODSThe cohort of 323 couple participants aged 22-46 was recruited from Jan. 2013 to Jun. 2018. At enrollment, resident address information was obtained and semen parameters of male counterparts were evaluated according to WHO criteria. We used inverse distance weighting interpolation to estimate the levels of ambient pollutants (SO₂, O₃, CO, NO₂, PM_2.5, and PM₁₀) in the surrounding area. The exposure of each participant was estimated based on the data gathered from air quality monitoring stations and their home address over various periods (0-9, 10-14, and 0-90 days) before semen sampling. The generalized linear regression model (GLM) and the Bayesian kernel machine regression (BKMR) were used to analyze the associations between pollutants, semen parameters, prosaposin, and normal fertilization. Additionally, the mediating effect of prosaposin and semen parameters on the link between pollutants and normal fertilization was investigated.RESULTSGLM and BKMR showed exposure to ambient air pollutants was all associated with the concentration of seminal prosaposin, among them, O₃ and CO were also associated with normal fertilization (-0.10, 95 %CI: -0.13, -0.06; -26.43, 95 %CI: -33.79, -19.07). Among the semen parameters, only the concentration of prosaposin and total motile sperm count (TMC) was associated with normal fertilization (0.059, 95 %CI: 0.047, 0.071; 0.016, 95 %CI: 0.012, 0.020). Mediation analysis showed that prosaposin played a stronger mediating role than TMC in the relationship between short-term exposure to O₃ and fertilization (66.83 %, P<0.001 versus 3.05 %, P>0.05).CONCLUSIONSeminal plasma prosaposin showed a stronger meditating effect reflect the correlation between ambient air pollutants and normal fertilization rate than conventional semen parameters, which may be used as one of the indicators between pollution and fertilization in IVF.

2024-06-01·Tissue and Cell

Selective prosaposin expression in Langerhans islets of the mouse pancreas

Article

作者: Fuyuki, Aimi ; Sohel, Md Shahriar Hasan ; Kitamura, Kai ; Takashima, Shigeo ; Onouchi, Sawa ; Homma, Takeshi ; Saito, Shouichiro

The islets of Langerhans are clusters of endocrine cells surrounded by exocrine acinar cells in the pancreas. Prosaposin is a housekeeping protein required for normal lysosomal function, but its expression level is significantly different among tissues. Prosaposin also exists in various body fluids including serum. Intracellularly, prosaposin activates lysosomes and may support autophagy, and extracellularly, prosaposin promotes survival of neurons via G protein-coupled receptors. In this study, prosaposin and its mRNA expression were examined in endocrine cells of the islets as well as in exocrine acinar cells in the pancreas of mice by in situ hybridization and immunostaining. High expression levels of prosaposin were found in Alpha, Beta and Delta cells in the islets, whereas prosaposin mRNA expression was faint or negative and prosaposin immunoreactivity was negative in exocrine acinar cells. The high expression levels of prosaposin in endocrine cells may indicate that prosaposin plays a crucial role in crinophagy, which is a characteristic autophagy in peptide-secreting endocrine cells, and/or that prosaposin is secreted from pancreatic islets. Since prosaposin has been reported in serum, this study suggests a new possible function of the Langerhans islets.

100 项与 Prosaptide TX14 A 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
HIV血清阳性	临床2期	-	Savient Pharmaceuticals, Inc.	2003-09-01
神经痛	临床2期	-	Savient Pharmaceuticals, Inc.	2003-09-01
糖尿病性神经病变	临床2期	-	Savient Pharmaceuticals, Inc.	-
糖尿病性神经病变	临床2期	美国	-	-