Amplifying the photovoltaic properties of phenylene dithiophene core based non-fused ring by engineering the terminal acceptors modification to enhance the efficiency of organic solar cells.

Article

作者: Khera, Rasheed Ahmad ; Rashid, Ehsan Ullah ; Nasr, Samia ; Alatawi, Naifa S ; Yahia, I S ; Iqbal, Javed ; Mehmood, Rana Farhat ; Raza, Ahmad

In this study, a series of eight non-fused rings-based semiconducting acceptors (AR1-AR8) were computationally developed by making modifications to the parent molecule (PTICO). In this study, a DFT analysis was conducted at an accurately chosen level of theory to gather a comprehensive inventory of the optoelectronic characteristics of AR1-AR8 and PTICO. The findings indicate that all recently developed molecules exhibit a bathochromic shift in their maximum UV-visible absorbance (λ_max) with a smaller band gap (E_g). AR1 has demonstrated the most significant red shift in UV-visible absorbance and possesses the smallest E_g when compared to other recently developed acceptors. AR2 acceptor has shown the best results both as electron and hole-transporting materials owing to its smallest value of reorganization energy for electrons and holes. J61 donor was engaged to calculate the open-circuit voltage (V_OC) and the highest V_OC with maximum FF % value was observed in AR4. The investigation of charge transfer was also conducted utilizing J61 in conjunction with the AR4 acceptor. Natural transition orbitals (NTO) have also been inspected to recognize the percentage electron transport contribution (% ETC) from the ground state to the first excites state (S₀ to S₁). The findings of this research suggest that the modified acceptors exhibit potential for practical implementation in the development of organic solar cells that possess improved photovoltaic performance.

2023-06-01·Journal of Ethnopharmacology

Identification of an effective fraction from Ampelopsis Radix with anti-dengue virus activities in vitro and in vivo

Article

作者: Lu, Zibin ; Qin, Zhiran ; He, Xuemei ; Yang, Jiabin ; Tang, Qingfa ; Chen, Xi ; Yu, Jianhai ; Yu, Linzhong ; Tong, Xiankun ; Zhao, Wei ; Huang, Hefei ; Cao, Huihui ; Yan, Lijun ; Zheng, Yuanru ; Tian, Chunyang ; Liu, Junshan ; Yang, Tangjia ; Shi, Lingzhu

ETHNOPHARMACOLOGICAL RELEVANCEDengue virus (DENV) infection is a global public health issue without effective therapeutic interventions. Chinese medicine with heat-clearing and detoxifying properties has been frequently used in the treatment of viral infection. Ampelopsis Radix (AR) is a traditional Chinese medicine for clearing heat and detoxification that has been widely used in the prevention and treatment of infectious diseases. However, no studies on the effects of AR against viral infection have been reported, thus far.AIM OF THE STUDYTo explore the anti-DENV activities of the fraction (AR-1) obtained from AR both in vitro and in vivo.MATERIALS AND METHODSThe chemical composition of AR-1 was identified by liquid chromatography-tandem MS (LC‒MS/MS). The antiviral activities of AR-1 were studied in baby hamster kidney fibroblast BHK-21 cells, ICR suckling mice and induction of interferon α/β (IFN-α/β) and IFN-γ R^-/- (AG129) mice.RESULTSBased on LC‒MS/MS analysis, 60 compounds (including flavonoids, phenols, anthraquinones, alkaloids and other types) were tentatively characterized from AR-1. AR-1 inhibited the cytopathic effect, the production of progeny virus and the synthesis of viral RNA and proteins by blocking DENV-2 binding to BHK-21 cells. Moreover, AR-1 significantly attenuated weight loss, decreased clinical scores and prolonged the survival of DENV-infected ICR suckling mice. Critically, the viral load in blood, brain and kidney tissues and the pathological changes in brain were remarkably alleviated after AR-1 treatment. Further study on AG129 mice showed that AR-1 obviously improved the clinical manifestations and survival rate, reduced viremia, attenuated gastric distension and relieved the pathological lesions caused by DENV.CONCLUSIONSIn summary, this is the first report that AR-1 exhibits anti-DENV effects both in vitro and in vivo, which suggests that AR-1 may be developed as a therapeutic candidate against DENV infection.

2023-02-14·ACS Omega

Adsorption Properties of Anionic Dyes on Quaternized Microcrystalline Cellulose

Article

作者: Li, Zhenbiao ; Wang, Xiaojuan ; Ouyang, Jinyu ; Miao, Jincheng ; Xing, Lei

Efficient removal of dyes in the wastewater of dyeing and printing industries is challenging, especially the anionic dyes with strong stability, serious environmental pollution, and difficult degradation. In the present work, a novel cationic adsorbent was synthesized through the quaternization of 2,3-epoxypropyltrimethylammonium chloride (GTA) onto microcrystalline cellulose and characterized by Fourier transform infrared spectroscopy, X-ray diffraction, specific surface and pore size analysis, and scanning electron microscopy. Acid Yellow 128 (AY-128) and Acid Red 1 (AR-1) were selected to investigate their adsorption on quaternized microcrystalline cellulose (QMCC). The experimental adsorption results indicated that (1) the adsorption kinetics of AY-128 and AR-1 on QMCC could be consistent with the pseudo-second-order and Freundlich models, respectively; (2) the adsorption process was spontaneous and feasibly endothermic. The removal efficiency of AY-128 and AR-1 was up to 99 and 95%, respectively. After five times of reuse, the removal efficiency of AY-128 and AR-1 was still 97 and 95%. In conclusion, quaternized microcrystalline cellulose was a promising adsorbent for AY-128 and AR-1.

100 项与 AR-1 (Arstat) 相关的药物交易

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