IY 7640 (Il-Yang Pharmaceuticals)(IY 7640 (Il-Yang Pharmaceuticals)) - 药物靶点：hemagglutinin_在研适应症：流感病毒感染_专利_临床

概要

基本信息

药物类型

小分子化药

别名

TEPIK

靶点

hemagglutinin

作用机制

hemagglutinin抑制剂(血凝素抑制剂)

治疗领域

感染呼吸系统疾病

在研适应症

流感病毒感染

非在研适应症-

原研机构

IlYang Pharmaceutical Co., Ltd.

在研机构

IlYang Pharmaceutical Co., Ltd.

Korea University

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 IY 7640 (Il-Yang Pharmaceuticals) 相关的临床结果

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100 项与 IY 7640 (Il-Yang Pharmaceuticals) 相关的转化医学

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100 项与 IY 7640 (Il-Yang Pharmaceuticals) 相关的专利（医药）

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1

项与 IY 7640 (Il-Yang Pharmaceuticals) 相关的文献（医药）

2019-09-01·Journal of Virology2区 · 医学

Novel Small Molecule Targeting the Hemagglutinin Stalk of Influenza Viruses

2区 · 医学

Article

作者: Park, Mee Sook ; Cho, Dae-Jin ; Ok, Kiwon ; Kim, Hong-Youb ; Woo, Seok-Hun ; Kim, Jin Il ; Ju, Hyun Soo ; Heo, Jun ; Kim, Dong-Yeon ; Lee, Sangmoo ; Byun, Youngjoo ; Ahn, Chung Am ; Lee, Gong Yeal ; Bang, Hye Jin ; Shin, Jae Soo ; Park, Man-Seong ; Lee, Hae Un ; Bae, Joon-Yong ; Park, Sehee

Anti-influenza drugs with broad-spectrum efficacy against antigenically diverse influenza viruses can be highly useful when no vaccines are available. To develop new anti-influenza drugs, we screened a number of small molecules and identified a strong candidate, IY7640. When added at the time of or after influenza virus infection, IY7640 was observed to successfully inhibit or reduce viral replication in cells. We subsequently discovered that IY7640 targets the stalk region of the influenza HA protein, which exhibits a relatively high degree of amino acid sequence conservation across various (sub)types of influenza viruses. Furthermore, IY7640 was observed to block HA-mediated membrane fusion of H1N1, H3N2, and influenza B viruses in cells. Although it appears less effective against strains other than H1N1 subtype viruses in a challenge study in mice, we suggest that the small molecule IY7640 has potential to be optimized as a new anti-influenza drug.

100 项与 IY 7640 (Il-Yang Pharmaceuticals) 相关的药物交易

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