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更新于：2026-04-02
Cefditoren Pivoxil
头孢托仑酯
更新于：2026-04-02
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1994-04-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C25H28N6O7S3 |
InChIKeyAFZFFLVORLEPPO-UVYJNCLZSA-N |
CAS号117467-28-4 |
关联
34
项与 头孢托仑酯 相关的临床试验CTR20260130
头孢托仑匹酯颗粒在中国健康受试者中进行的单中心、随机、开放、单次（空腹/餐后）口服给药、两制剂、两序列、两周期、交叉的人体生物等效性试验
CTR20253726
头孢托仑匹酯颗粒的餐后生物等效性研究
CTR20253725
头孢托仑匹酯颗粒的空腹生物等效性研究
100 项与 头孢托仑酯 相关的临床结果
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100 项与 头孢托仑酯 相关的转化医学
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100 项与 头孢托仑酯 相关的专利（医药）
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294
项与 头孢托仑酯 相关的文献（医药）2026-04-01JOURNAL OF CONTROLLED RELEASE
A multidomain peptide hydrogel-liposome composite for controlled release of a cyclic dinucleotide in oral cancer
Article
作者: Sunga, Gemalene M ; Perez, Alejandra Cobos ; Molina, Andrea H ; Vázquez-Rosado, Ephraim J ; Swain, Joseph W R ; Dharmaraj, Neeraja ; Young, Simon ; Hartgerink, Jeffrey D ; Dey, Arghadip ; Chew-Martinez, Danielle
While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel-liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both anionic (E2) and cationic (K2) peptide hydrogels and found that E2 caused aggregation to occur at the desired lipid:peptide molar ratio, which led to our use of K2 in the composite system. At a molar ratio of 8:1 lipid:peptide, K2-Lip(CDN) formed a self-healing composite hydrogel and resulted in prolonged release of CDN in vitro and indocyanine green (ICG) in vivo. This composite material resulted in cellular cytotoxicity in ROC1 oral cancer cells in vitro and extended survival in an aggressive ROC1 tumor-bearing murine model compared to a single CDN injection. The overall survival using only a single dose of K2-Lip(CDN) was equivalent to that achieved with six repeated doses of CDN. The material properties and extended-release capabilities displayed by peptide hydrogel-liposome composite systems could translate to broad treatment applications that require the delayed release of localized therapeutics.
2026-01-20JOURNAL OF VIROLOGY
A recurrent adaptive mutation in the transmembrane 2B protein of an insect picorna-like virus in a nonnative host
Article
作者: Huynen, Martijn A. ; Beerenwinkel, Niko ; Stevens, Milou ; Fuhrmann, Lara ; van Rij, Ronald P. ; Lezcano, Oscar M. ; Bos, Reinder T. ; Wang, Haitao
ABSTRACT:
Virus emergence is often due to cross-species transmission and adaptation to the new host. We studied the effect of innate immune responses on shaping virus populations in native and nonnative virus-host combinations, using as a model system
Drosophila melanogaster
infected with either Drosophila C virus (DCV) or cricket paralysis virus (CrPV). In this host, the cGAS-like receptor 1 senses viral double-stranded RNA and produces cyclic dinucleotides (CDNs) to activate the STING protein and induce an antiviral response. Both viruses were serially passaged in three host conditions differing in their cGAS-STING response: wild-type (WT) flies,
Sting
knock-out (KO) flies, and flies with a primed immune response by CDN injection. We found no immune-related effects on virus evolution, but we uncovered the CrPV nonstructural 2B protein as a key regulator of cross-species transmission. Nucleotide diversity specifically accumulated in the
2B
gene during passage of CrPV in its nonnative
Drosophila
host, while
2B
of the fly-adapted DCV displayed markedly lower and constant nucleotide diversity. In particular, the CrPV 2B D29N variant was selected in all six virus lineages evolved in WT and
Sting
KO flies, with an estimated selection coefficient greater than 0.2. This variant replicated faster and was more lethal than the parental virus in all three host backgrounds. 2B is a predicted transmembrane protein, which we found to be associated with cellular endomembranes and may be involved in replication organelle formation. Our findings suggest a role for the 2B protein in adaptation to a new host independent of the cGAS-STING pathway.
IMPORTANCE:
The forces driving virus evolution are central to understanding cross-species transmission and virus emergence. It is well established that the adaptive immune system drives virus evolution in mammals, but whether innate responses likewise drive virus evolution upon host shifts is less well understood. In this manuscript, we used
Drosophila melanogaster
as a model to study the evolution of a native and a nonnative pathogen under conditions in which innate antiviral immunity is either abolished or enhanced. Using an experimental evolution approach, we find little evidence for adaptive evolution of the natural pathogen Drosophila C virus. In contrast, we observed a recurrent adaptive mutation in the viral nonstructural 2B protein in the nonnative cricket paralysis virus, independent of the antiviral cGAS/STING pathway. Our work provides insights into viral adaptation to new hosts and the characteristics of the 2B protein of dicistroviruses, a family comprising important model insect viruses.
2026-01-15JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Enhancing rice grain yield and quality synergistically through controlled irrigation and increased planting density in nitrogen‐reduced systems
Article
作者: Ji, Guangmei ; Li, Lijiang ; Li, Min ; Luo, Danqiu ; Zhang, Jiafeng ; Tian, Jinyu ; Jiang, Mingjin
Abstract:
BACKGROUND:
Ensuring high yield and improved grain quality is crucial for stabilizing rice production and guaranteeing food security. The present study aimed to investigate whether controlled irrigation and increased planting density within a nitrogen‐reduced system can synergistically enhance grain yield and quality to secure food supply. The hybrid indica rice variety Jingliangyou534 was cultivated in the field using four management practices: traditional high‐yield cultivation (CK), mono reduced nitrogen rate (MN), reduced nitrogen rate with increased planting density (DN), and DN combined with alternative wetting and moderate soil drying irrigation (CDN).
RESULTS:
The findings indicated that the nitrogen‐reduced systems resulted in a grain yield reduction of 0.64–6.08% but enhanced cooked rice taste and comprehensive by 8.37–27.66% and 4.15–8.71%, respectively, compared to CK. The grain yield of hybrid indica rice in nitrogen‐reduced systems exhibited the following order: CK > CDN > DN > MN. Conversely, the taste of cooked rice indicated a preference ranking of CDN > MN > DN > CK. In comparison with CK, the CDN treatment slightly decreased grain yield but significantly improved the milled rice rate, head milled rice rate, cooked rice taste quality (including taste, appearance and comprehensive) and rice starch viscosity parameters (peak viscosity, trough viscosity, final viscosity and breakdown), at the same time as reducing the chalkiness rate, chalkiness degree, protein content and setback.
CONCLUSION:
The findings suggest that implementing a moderate reduction in nitrogen rate, within the context of high‐yield cultivation, can enhance the taste quality of rice, albeit with a reduction in yield. Although increased planting density may partially offset the adverse effects on rice yield following nitrogen reduction, it could potentially compromise rice quality. However, the integration of controlled irrigation and increased planting density within a nitrogen‐reduced system can synergistically enhance rice processing quality, appearance quality and the cooked rice taste quality, at the same time as sustaining high grain yield. © 2025 Society of Chemical Industry.
78
项与 头孢托仑酯 相关的新闻（医药）2026-03-29
·信狐药迅
100 项与 头孢托仑酯 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 社区获得性肺炎 | 美国 | 2002-08-21 | |
| 慢性支气管炎 | 美国 | 2001-08-29 | |
| 简单的皮肤和皮肤结构感染(uSSSI) | 美国 | 2001-08-29 | |
| 咽炎 | 美国 | 2001-08-29 | |
| 扁桃体炎 | 美国 | 2001-08-29 | |
| 细菌感染 | 日本 | 1994-04-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 膀胱炎 | 临床3期 | 希腊 | 2007-11-01 | |
| 膀胱炎 | 临床3期 | 西班牙 | 2007-11-01 | |
| 脓尿 | 临床3期 | 希腊 | 2007-11-01 | |
| 脓尿 | 临床3期 | 西班牙 | 2007-11-01 |
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