更新于：2024-11-04
Cefditoren Pivoxil
头孢托仑酯
更新于：2024-11-04
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 日本 (1994-04-01), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C25H28N6O7S3 |
InChIKeyAFZFFLVORLEPPO-UVYJNCLZSA-N |
CAS号117467-28-4 |
关联
18
项与 头孢托仑酯 相关的临床试验头孢托仑匹酯颗粒在健康受试者中单中心、随机、开放、两制剂、单次给药、两周期、双交叉空腹/餐后生物等效性试验研究
头孢托仑匹酯颗粒在中国健康受试者中空腹和餐后给药条件下随机、开放、单剂量、两制剂、两序列、两周期、双交叉生物等效性试验
头孢托仑匹酯片在健康人体内的生物等效性试验
100 项与 头孢托仑酯 相关的临床结果
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100 项与 头孢托仑酯 相关的转化医学
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100 项与 头孢托仑酯 相关的专利（医药）
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257
项与 头孢托仑酯 相关的文献（医药）2024-12-01POULTRY SCIENCE
Effects of cardamonin on the growth performance, intestinal barrier function and intestinal microbiota of Danzhou chickens under heat stress
Article
作者: Shi, Liguang ; Jiang, Haoran ; Xun, Wenjuan ; Hou, Guanyu ; Deng, Tanjie
The aim of this study was to investigate the effects of cardamonin (CDN) on the growth performance, intestinal mucosal barrier function and intestinal microbiota of Danzhou chickens under heat stress. A total of 200 one-day-old female Danzhou chickens were randomly divided into 5 groups. The daytime temperature of heat stress (HS) was set at 36 ± 2°C, and the nighttime temperature was kept the same as in the control (CON) group at 25 ± 2°C. The formal experiment lasted for 21 d. The CON and HS groups were fed a basal diet, whereas the L-CDN, M-CDN, and H-CDN groups received a basal diet supplemented with 50, 100, and 200 mg/kg CDN, respectively. Compared with the HS group, the CDN group presented a significantly greater average daily gain (ADG) (P < 0.001) but a significantly lower feed-to-gain ratio (F/G) (P = 0.007). CDN supplementation also increased the villus height (VH) and the ratio of the villus height to crypt depth (V/C) (P < 0.001) and reduced intestinal permeability by increasing expression of the ZO-1 (P < 0.001), Occludin (P < 0.001), and Claudin-1 (P = 0.034) proteins and decreasing the content of D-lactic acid (D-LA) and the activity of diamine oxidase (DAO) in serum (P < 0.001). Additionally, CDN reduced the levels of the intestinal mucosal inflammatory factors (IL-1β (P = 0.031), IL-6 (P = 0.003), and TNF-α (P = 0.014)) while upregulating IL-10 (P < 0.001). Furthermore, it increased the total antioxidant capacity (T-AOC) (P = 0.004) and catalase (CAT) activity (P < 0.001) and reduced the malondialdehyde (MDA) content (P = 0.017), effectively reducing intestinal oxidative stress and inflammatory reactions. Expression of the Nrf2 pathway-related proteins Nrf2 (P = 0.012), HO-1 (P = 0.008), and NQO1 (P = 0.003) was also increased by CDN. Moreover, feeding CDN increased the proportion of beneficial bacteria such as Firmicutes and Bacteroidetes but decreased the proportion of harmful bacteria such as Proteobacteria, thus protecting the intestinal barrier. In summary, 200 mg/kg CDN in the diet improved growth performance, enhanced intestinal barrier function and improved intestinal flora disorders in heat stress-induced Danzhou chickens, which may be related to the Nrf2/NQO1 signaling pathway.
2024-08-16JOURNAL OF ORGANIC CHEMISTRY
Design and Synthesis of Cyclic Dinucleotide Analogues Containing Triazolyl C-Nucleosides
Article
作者: Chen, Chang-Po ; Xie, Di ; Dong, Wenpei ; Jiang, Tao ; Yan, Jiayin ; Xu, Hui ; Hou, Ke ; Ma, Jinliang ; Cao, Yaru
Natural cyclic dinucleotide (CDN) is the secondary messenger involved in bacterial hemostasis, human innate immunity, and bacterial antiphage immunity. Synthetic CDN and its analogues are key molecular probes and potential immunotherapeutic agents. Several CDN analogues are under clinical research for antitumor immunotherapy. A myriad of synthetic methods have been developed and reported for the preparation of CDN and its analogues. However, most of the protocols require multiple steps, and only one CDN or its analogue is prepared at a time. In this study, a strategy based on a macrocyclic ribose phosphate skeleton containing a 1'-alkynyl group was designed and developed to prepare CDN analogues containing triazolyl C-nucleosides by click chemistry. Combinatorial application of click chemistry and the sulfenylation cascade to the macrocyclic skeleton expanded the diversity of the CDN analogues. This macrocyclic skeleton strategy rapidly and efficiently provides CDN analogues to facilitate research on microbiology, immunology, and immunotherapy.
2024-08-01PHARMACEUTICAL RESEARCH
Correction: Comment on the article: In vivo Pharmacokinetics/Pharmacodynamics Profiles for Appropriate Doses of Cefditoren pivoxil against S. pneumoniae in Murine Lung-Infection Model
作者: Alou, L ; Sevillano, D ; Giménez, M J ; Aguilar, L
100 项与 头孢托仑酯 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 社区获得性肺炎 | 美国 | 2002-08-21 | |
| 慢性支气管炎 | 美国 | 2001-08-29 | |
| 简单的皮肤和皮肤结构感染(uSSSI) | 美国 | 2001-08-29 | |
| 扁桃体炎 | 美国 | 2001-08-29 | |
| 细菌感染 | 日本 | 1994-04-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 急性膀胱炎 | 临床3期 | 希腊 | 2007-11-01 | |
| 急性膀胱炎 | 临床3期 | 西班牙 | 2007-11-01 | |
| 泌尿道感染 | 临床3期 | 希腊 | 2007-11-01 | |
| 泌尿道感染 | 临床3期 | 西班牙 | 2007-11-01 |
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