Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2) In Absorbable Collagen Membrane With Coronally Advanced Flap In Class I And II Gingival Recession Defects -A Randomized Control Trial

This study was a single-arm trial to obtain preliminary data on the efficacy of collagen membranes impregnated with recombinant human fibroblast growth factor (rhFGF-2) in the treatment of Miller's class I and class II gingival recessions.

开始日期2019-05-01

申办/合作机构

SVS Institute of Dental Sciences

100 项与 Recombinant Human Fibroblast Growth Factor-2(SVS Institute of Dental Sciences) 相关的临床结果

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100 项与 Recombinant Human Fibroblast Growth Factor-2(SVS Institute of Dental Sciences) 相关的专利（医药）

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111

项与 Recombinant Human Fibroblast Growth Factor-2(SVS Institute of Dental Sciences) 相关的文献（医药）

2024-08-01·Journal of Periodontal Research

Predictive factors of periodontal regeneration outcomes using rhFGF‐2: A case–control study

Article

作者: Nakashima, Fuminori ; Iwata, Tomoyuki ; Sasaki, Shinya ; Hamamoto, Yuta ; Ueda, Tomoya ; Kakimoto, Naoya ; Ouhara, Kazuhisa ; Yasuda, Keisuke ; Mizuno, Noriyoshi ; Mihara, Naoki ; Ninomiya, Yurika ; Matsuda, Shinji

AbstractObjectiveThis study aimed to investigate the factors influencing the clinical outcomes of regenerative therapy using recombinant human fibroblast growth factor‐2 (rhFGF‐2).BackgroundrhFGF‐2 promotes periodontal regeneration, and identifying the factors influencing this regeneration is important for optimizing the effectiveness of rhFGF‐2.Methods and MaterialsThis study used a hospital information‐integrated database to identify patients who underwent periodontal regenerative therapy with rhFGF‐2. Factors included age, smoking status, diabetes mellitus (DM), periodontal inflamed surface area (PISA) at the initial visit, whether the most posterior tooth was involved or not, and preoperative radiological bone defect angle. Periodontal regenerative therapy outcomes were defined as good if radiographic bone fill ≥35% or periodontal pocket closure at 9–15 months after surgery. Bone fill rate (%) and periodontal pocket depth (mm) were also used as outcome measures. Factors were evaluated by simple regression analysis, and then the association between factors and the outcomes was determined by multivariate analysis.ResultsPISA and age at the first visit did not significantly influence the success or failure of bone fill rate byrhFGF‐2. However, DM, radiographic bone defect angle, and the most posterior tooth significantly influenced the regenerative effect (success/failure in bone fill) of rhFGF‐2. The most posterior tooth was significantly associated with bone fill rate by rhFGF‐2. Examination of the association between pocket closure and factors shows that the most posterior tooth significantly influenced. The most posterior tooth and preoperative PPD were significantly associated with pocket reduction depth. For the most posterior tooth, a significantly higher bone regeneration rate (p < .05) was observed with a combination of autologous bone graft and rhFGF‐2 than with rhFGF‐2 alone, and the effect was significant in multivariate analysis.ConclusionsThe radiographic bone defect angle, the involvement of most posterior teeth, and the presence of DM influenced the effectiveness of rhFGF‐2 in periodontal regeneration. However, PISA values and age at the initial visit had no significant effect.

2024-06-01·Clinical Advances in Periodontics

Double‐sided entire papilla preservation technique in the combination periodontal regenerative therapy: A case report

Article

作者: Ishikawa, Tomohiro ; Yoshikawa, Kouki ; Ogawa, Yudai ; Imamura, Kentaro ; Saito, Atsushi

AbstractBackgroundWith the entire papilla preservation (EPP) technique, it is possible to perform regenerative therapy without incisions in the interdental papilla and to reduce the risk of papillary rupture. However, one limitation of the EPP is the sole access from the buccal side. Here, we present a case of periodontitis treated by the combination regenerative therapy employing the Double‐sided (buccal‐palatal) EPP (DEPP) technique, which adds a palatal vertical incision to the EPP.MethodsA patient with 1–2 wall intrabony defects received the regenerative therapy using recombinant human fibroblast growth factor (rhFGF)‐2 and carbonate apatite (CO3Ap). Using the DEPP technique, vertical incisions at buccal and palatal aspects were placed to gain adequate access to the 1–2 wall intrabony defects between #11 and #12 without incision in the interdental papilla. After debridement, rhFGF‐2 and CO3Ap were applied to the defect. Periodontal clinical parameters and radiographic images were evaluated at the first visit, following initial periodontal therapy (baseline), 6, 9, and 12 months postoperatively.ResultsWound healing was uneventful. Scarring of the incision lines was minimal. At 12 months postoperatively, probing depth reduction was 4 mm, clinical attachment gain was 4 mm, and gingival recession was not observed. An improvement in radiopacity in the previous bone defect was observed.ConclusionThe DEPP is an innovative technique that allows approaching from both the buccal and palatal sides while ensuring flap extensibility without compromising the interdental papilla. This report suggests that the combination of regenerative therapy with the DEPP may be promising in the treatment of intrabony defects.Key pointsWhy is this case new information?

The DEPP allows a direct visual approach to a 1–2 wall intrabony defect extending from the buccal to palatal sides, and increases flap extensibility, without compromising the papilla.

What are the keys to the successful management of this case?

Assessment of three‐dimensional bone defect morphology is required. Computed tomography images are very useful. The flap elevation just under the interdental papilla should be carefully performed with a small excavator to avoid damage to the interdental papilla.

What are the primary limitations to success in this case?

Despite the addition of a palatal incision, it was not possible to obtain complete flexibility of the palatal gingiva. Caution must be taken in a case in which the distance between the interdental papilla is narrow. Even if the interdental papilla is ruptured during the operation, recovery is possible by continuing the operation and suturing the rupture at the end.

2024-01-10·International Journal of Periodontics & Restorative Dentistry

Entire Papilla Preservation Technique with Recombinant Human Fibroblast Growth Factor-2 and Autogenous Bone Grafting in the Treatment of Isolated Non-Contained Intrabony Defect: Case Report of a 5-Year Follow-Up

Article

作者: Ogawa, Yudai ; Aslan, Serhat ; Nara, Yoshitaka

Regenerative periodontal surgery is an effective procedure for the treatment of intrabony defects. Various flap designs preserving the defect-associated interdental papilla have been proposed to improve early wound stability. This case report describes the long-term results of a regenerative treatment in severely compromised mandibular canine using entire papilla preservation technique. Surgical access was provided by a single buccal vertical incision without any papilla incision. Combination of autogenous bone harvested from the same surgical site and recombinant human fibroblast growth factor-2 was applied to non-contained intrabony defect following the granulation tissue removal. Surgical site was closed with single interrupted sutures. The clinical outcomes and 5-year stability of pocket closure with no increase in gingival recession show the potential of entire papilla preservation technique with the use of combined biomaterials.

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
获得性免疫缺陷综合征	临床2期	-	Universidade Federal Fluminense	2002-12-31
侵袭性牙周炎	临床2期	-	Universidade Federal Fluminense	2002-12-31
白塞病/贝赫切特综合征	临床2期	-	Universidade Federal Fluminense	2002-12-31
骨缺陷	临床2期	-	Universidade Federal Fluminense	2002-12-31
慢性牙周炎	临床2期	-	Universidade Federal Fluminense	2002-12-31
2型糖尿病	临床2期	-	Universidade Federal Fluminense	2002-12-31
牙龈退缩	临床2期	-	Universidade Federal Fluminense	2002-12-31
口腔出血	临床2期	-	Universidade Federal Fluminense	2002-12-31
脓毒症	临床2期	-	Universidade Federal Fluminense	2002-12-31