预约演示

更新于：2025-05-07

18F-RP-170

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药、诊断用放射药物

别名

靶点-

作用方式-

作用机制-

治疗领域

心血管疾病

在研适应症-

非在研适应症

心肌缺血

原研机构

Pola Chemical Industries, Inc.

在研机构-

非在研机构

Pola Chemical Industries, Inc.

权益机构-

最高研发阶段终止临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构/序列

分子式C7H10FN3O4

InChIKeyAPIKHHGQEBCQED-COJKEBBMSA-N

CAS号291764-48-2

关联

项与 18F-RP-170 相关的临床试验

JPRN-jRCTs031190133

/ Completed临床2期IIT

Clinical research on the superiority of 18F-FRP170 over 18F-FMISO for tumor hypoxia imaging

开始日期2019-11-13

申办/合作机构-

100 项与 18F-RP-170 相关的临床结果

登录后查看更多信息

100 项与 18F-RP-170 相关的转化医学

登录后查看更多信息

100 项与 18F-RP-170 相关的专利（医药）

登录后查看更多信息

项与 18F-RP-170 相关的文献（医药）

2015-05-01·Annals of Nuclear Medicine4区 · 医学

High-uptake areas on positron emission tomography with the hypoxic radiotracer 18F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia

4区 · 医学

Article

作者: Ogasawara, Kuniaki ; Takai, Yoshihiro ; Sasaki, Makoto ; Ehara, Shigeru ; Saura, Hiroaki ; Iwata, Ren ; Mtsuura, Hideki ; Beppu, Takaaki ; Sasaki, Toshiaki ; Terasaki, Kazunori

AbstractObjectiveThe aim was to evaluate the proliferative activity of high-uptake areas on positron emission tomography (PET) with the hypoxic cell radiotracer, 1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole (FRP170).MethodsThirteen patients with glioblastoma underwent FRP170 PET before tumor resection. During surgery, tumor specimens were stereotaxically obtained from regions corresponding to high (high-uptake areas, HUAs) and relatively low (low-uptake areas, LUAs) accumulation of FRP170. We compared immunohistochemical staining for Ki-67 and hypoxia-inducible factor (HIF)-1α between HUA and LUA.ResultsHIF-1α index was significantly higher in HUAs than in LUAs. In contrast, mean Ki-67 indices did not differ significantly between HUAs and LUAs.ConclusionsFindings for HIF-1α index clearly indicated that HUAs on FRP170 PET represented hypoxic regions in glioblastoma. However, findings of Ki-67 index suggest that HUAs on FRP170 PET include regions retaining proliferative activity regardless of tissue hypoxia.

2015-05-01·Stroke1区 · 医学

Hypoxic Viable Tissue in Human Chronic Cerebral Ischemia Because of Unilateral Major Cerebral Artery Steno-Occlusive Disease

1区 · 医学

Article

作者: Takai, Yoshihiro ; Beppu, Takaaki ; Saura, Hiroaki ; Yoshida, Koji ; Kobayashi, Masakazu ; Ogawa, Akira ; Yoshida, Kenji ; Terasaki, Kazunori ; Ogasawara, Kuniaki

Background and Purpose— Positron emission tomography (PET) with radiolabeled 2-nitroimidazoles directly detects hypoxic but viable tissue present in an acute ischemic area in the human brain. This study using PET with 1-(2- 18 F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole ( 18 F-FRP170) aimed to determine whether tissue with an abnormally elevated uptake of 18 F-FRP170 exists in human chronic cerebral ischemia because of unilateral atherosclerotic major cerebral artery steno-occlusive disease. Methods—18 F-FRP170 PET was performed, and cerebral blood flow and metabolism were assessed using 15 O-gas PET in 20 healthy subjects and 52 patients. A region of interest (ROI) was automatically placed in 3 segments of the middle cerebral artery territory in both cerebral hemispheres with a 3-dimensional stereotaxic ROI template using SPM2, and each PET value was determined in each ROI. The ratio of values in the affected versus contralateral hemispheres was calculated for the 18 F-FRP170 PET image. Results— A significant correlation was observed between oxygen extraction fraction and 18 F-FRP170 ratios ( ρ =0.509; P <0.0001) in a total of 156 ROIs in 52 patients. The specificity and positive-predictive value for a combination of an elevated oxygen extraction fraction and a moderately reduced cerebral oxygen metabolism for detection of an abnormally elevated 18 F-FRP170 ratio (19 ROIs: 12%) were significantly greater than those for the individual categories (elevated oxygen extraction fraction, moderately reduced cerebral oxygen metabolism, or reduced cerebral blood flow). Conclusions— Tissues with abnormally elevated uptake of 18 F-FRP170 exist in human chronic cerebral ischemia characterized by a combination of misery perfusion and moderately reduced oxygen metabolism because of unilateral atherosclerotic major cerebral artery steno-occlusive disease.

2010-08-01·Journal of Neurosurgery1区 · 医学

Clinical article

1区 · 医学

Article

作者: Watanabe, Mika ; Takai, Yoshihiro ; Tominaga, Teiji ; Saito, Ryuta ; Takanami, Kentaro ; Kumabe, Toshihiro ; Higano, Shuichi ; Sonoda, Yukihiko ; Kanamori, Masayuki ; Shibahara, Ichiyo ; Iwata, Ren

ObjectAssessment of hypoxic conditions in brain tumors is important for predicting tumor aggressiveness and treatment response. A new hypoxia imaging agent, 1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole (FRP-170), with higher image contrast and faster clearance than preexisting hypoxia tracers for PET, was used to visualize hypoxic tissues in 8 patients with glioma.MethodsThe FRP-170 was injected and PET imaging was performed 2 hours later in 8 patients, including 3 with glioblastoma multiforme, 2 with oligodendroglioma, and 1 each with diffuse astrocytoma, anaplastic ganglioglioma, and recurrent anaplastic astrocytoma. All 8 patients also underwent MR imaging, and some patients underwent [11C]methionine or [18F]fluorodeoxyglucose PET, and proton MR spectroscopy for comparison. Tissues obtained at biopsy or radical resection were immunostained with hypoxia-inducible factor–1α (HIF-1α) antibody for the confirmation of hypoxia, except in the patient with recurrent anaplastic astrocytoma who was treated using Gamma Knife surgery.ResultsThe FRP-170 PET images showed marked uptake with upregulation of HIF-1α in the 3 glioblastomas multiforme, and moderate uptake in the recurrent anaplastic astrocytoma and one oligodendroglioma, but no uptake in the other tumors. The FRP-170 PET images showed positive correlation with HIF-1α immunoreactivity and some correlation with FDG PET and MR imaging enhancement, but no correlation with [11C]methionine PET. Imaging with FRP-170 PET seemed to be more sensitive for detecting hypoxia than identifying the lactate peak on proton MR spectroscopy.ConclusionsImaging with FRP-170 PET can visualize hypoxic lesions in patients with glioma, as confirmed by histological examination. This new method can assess tumor hypoxia preoperatively and noninvasively.

100 项与 18F-RP-170 相关的药物交易

登录后查看更多信息

研发状态

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASTRO2005	N/A	缺氧	-	[18F]FRP-170 (WHT/Ht albino mice)	遞鏇繭構壓鏇願鑰窪襯(簾築遞淵窪廠顧積鹹觸) = very low, they are about 0.2 for thigh, heart, mediastinum and neck; higher (ca. 0.6) for liver and kidney 憲願壓蓋築鹹獵夢襯簾 (繭鹹膚壓鏇顧獵積鬱觸 ) 更多	-	2005-10-01
				[18F]FRP-170 (Patients with recurrent esophageal cancer)