Mejiro University

We report the pharmacokinetic parameters of Clarith dry syrup 10% for pediatric in upper respiratory tract infection. Six subjects - 5 boys and 1 girl, age 6-10 (7.3 ± 1.6) years and having upper respiratory tract infection were treated with a 5 mg (potency)/kg oral dose of clarithromycin (CAM). Each had 6 blood samples taken with a 6 h period after CAM administration. Based on high-performance liquid chromatog. combined with an electrochem. detector (ECD-HPLC), we quant. analyzed CAM and (14R)-14-hydroxy-CAM (M-5) in serum. The ratio against pharmacokinetic parameters was (1) for CAM, C_max 1.05 ± 0.33 μg/mL, AUC 3.54 ± 1.14 μg/h/mL, and T_1/2 1.78 ± 0.28 h, (2) for M-5, C_max 0.98 ± 0.27 μg/mL, AUC 5.37 ± 1.68 μg/h/mL, and T_1/2 3.17 ± 0.59 h.

A review. The nonpolar and semipolar nitride semiconductors are the potential candidates for realization of new frontier devices with much better performance than their c-oriented counterparts. We explain why nonpolar nitride semiconductors are considered to possess enormous potential. In addition, we report on the crystal growth, conductivity control and device applications of nonpolar nitride semiconductors.

A review. Verification of dioxin problems including misunderstanding and misreading actual effects on human health.