Individualized Perioperative Open-luna Ventilatory Strategy With High Versus Conventional Inspiratory Oxygen Fraction (iPROVE-O2). A Comparative, Prospective, Multicenter, Randomized Controlled Trial

The iPROVE-O2 trial aims at comparing the efficacy of high and conventional FiO2 within a perioperative individualized ventilatory strategy to reduce the overall incidence of SSI.

开始日期2017-06-01

申办/合作机构

Hospital Universitario Principe De Asturias

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301

项与 Hospital Povisa SA 相关的文献（医药）

2025-03-01·Radiología (English Edition)

Fast cardiac magnetic resonance protocol. Feasibility of accelerated compressed sensing cine sequences in clinical practice

Article

作者: Hormaza Aguirre, N ; Delgado Sánchez-Gracián, C ; Pérez Fernández, S ; Capelastegui Alber, A ; Zarranz Sarobe, D ; Oca Pernas, R

OBJECTIVETo demonstrate the feasibility of cardiac magnetic resonance (CMR) cine sequences with compressed-sensing (CS) acceleration in the assessment of ventricular anatomy, volume, and function; and to present a fast CRM protocol that improves scan efficiency.METHODSProspective study of consecutive patients with indication for CMR who underwent CS short-axis (SA) cine imaging compared with conventional SA cine imaging. We analysed ejection fraction (EF), end-diastolic volume (EDV), stroke volume (SV), and myocardial thickness. Two blinded independent observers performed the reading. Inter- and intraobserver agreement was calculated for all the measurements. Image quality of conventional and CS cine sequences was also assessed.RESULTSA total of 50 patients were included, 22 women (44%) with a mean age of 57.3 ± 13.2 years. Mean left ventricular EF was 59.1% ± 10.4% with the reference steady-state free precession sequences, versus 58.7% ± 10.6% with CS; and right ventricular EF with conventional imaging was 59.3% ± 5.7%, versus 59.5% ± 6.1% with CS. Mean left ventricular EDV for conventional sequences and CS were 166.8 and 165.1 ml respectively; left ventricular SV was 94.5 versus 92.6 ml; right ventricular EDV was 159.3 versus 156.4 ml; and right ventricular SV was 93.6 versus 91.2 ml, respectively. Excellent intra and interobserver correlations were obtained for all parameters (Intraclass correlation coefficient between 0.932 and 0.99; CI: 95%). There were also no significant differences in ventricular thickness (12.9 ± 2.9 mm vs 12.7 ± 3.1 mm) (p < .001). The mean time of CS SA was <40 sec versus 6-8 min for the conventional SA. The mean duration of the complete study was 15 ± 3 min.CONCLUSIONSCine CS sequences are feasible for assessing biventricular function, volume, and anatomy, enabling fast CMR protocols.

2025-02-01·Physica Medica

Corrigendum to “PS10.16 ACTIVITY IN THE SALIVA OF rhTSH AND THW THYROID CANCER PATIENTS TREATED WITH IODINE-131” [Phys. Med. 125(Supplement 1) (2024) 104229]

作者: Garcia Perez-Schofield, J ; Gutierrez Mendiguchia, C ; Lorenzo Martinez, S ; Gomez Casal, A ; Pequeño Gonzalez, M ; Fernandez Diaz, A

2025-01-29·Open Forum Infectious Diseases

P-844. Bacteraemia Caused by High Risk AmpC-producing Enterobacterales: Influence of IDSA Guidelines Adequacy and Antimicrobial Stewardship Activity on Outcomes

作者: Canoa Rico, Alejandra ; Ortero, Judith Alvarez ; Gutierrez Garcia, Monica ; Lamas Ferreiro, Jose Luis ; Aguado, Javier de la Fuente ; Sanjurjo Rivo, Ana ; Costas Vila, Marta ; Valerio, Laura Intanno

AbstractBackgroundTreatment of high risk AmpC-producing Enterobacterales bloodstream infections (BSIs) is challenging due to the posibility of development of antibiotic resistance during treatment. The aim of this study was to analyze the impact of antimicrobial stewardship activity and IDSA guidelines adequacy in patients with high risk AmpC-producing Enterobacterales BSIs.MethodsPatients with Citrobacter spp, Enterobacter spp and Klebsiella aerogenes BSIs were included between June 2019-March 2024. Outcomes of death and relapse of infection at 30 days were assessed. Adequacy of definitive antimicrobial treatment according to IDSA guidelines was evaluated. The impact of antimicrobial stewardship activity in treatment adequacy and outcome was analyzed. Analysis was performed using SPSS version 25.Results2049 BSIs were evaluated and 67 were finally included. 80% were monomicrobial. Median patient age was 74 years, 73% were male. The most frequent microorganism isolated was Enterobacter cloacae (55%). 50% were nosocomial and the most frequent origen was biliary tract (35,8%). 35% met sepsis criteria. 30% of cases presented cefotaxim resistance. Empiric and definitive antibiotic treatment was prescribed according IDSA guidelinesi n 34% and 91% of cases, respectively.. Death at 30 days was 6% and a combination outcome of death and relapse of infection at 30 days was 11,9%. Definitive antibiotic treatment adequacy according to IDSA guidelines was associated with lower mortality and relapse at 30 days (OR 0,04; IC95 0,003-0,6; P=0,02). Antimicrobial stewardship team did an intervention in 34% cases. This intervention was associated with a trend toward of lower mortality and relapse (4% vs 15%, P=0,2), a trend toward of higher IDSA guidelines adequacy (100% vs 86%, P=0,08), and a higher switch to oral treatment (78% vs 52%; P=0,03).ConclusionAdequacy of definitive antimicrobial treatment in high risk AmpC producing Enterobacterales BSIs according to IDSA guidelines was associated with a better outcome. Antimicrobial stewardship is desired for management of these patients.DisclosuresAll Authors: No reported disclosures

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