Inflammatory and Brain Mechanisms and Clinical and Cognitive Effects of an Exercise Intervention in Major Depressive Disorder: a Randomised Longitudinal Clinical Trial.

The goal of this clinical trial is to study how physical exercise works when applied to patients diagnosed with Major Depressive Disorder (MDD). The main questions it aims to answer are:
What are the antiinflammatory and oxidative stress and neural mechanisms involved in the antidepressant effects of exercise?
How effective is a physical exercise program in MDD patients in real-life conditions?
The experimental group will receive an exercise intervention as an add-on to their usual treatment (antidepressant treatment prescribed by the attending specialist). Researchers will compare to a control group, which will only receive standard treatment (antidepressant treatment prescribed by the attending specialist) and will be instructed to not change their usual physical activity. The aim is to see if a physical exercise intervention would induce a significant improvement in depressive symptoms and which mechanisms are responsible for this result.

开始日期2024-09-01

申办/合作机构

Fundación para la Investigación Biomédica del Hospital

[+5]

NCT05913050 / RecruitingN/AIIT

Predicting ROtator Cuff Tears Outcomes After Physical Therapy Treatment (the PROTO Study): a Multivariable Prediction Model Development Study

The aim of this multicenter non-controlled study is to develop a multivariable prediction model of pain/disability improvements in patients with full-thickness rotator cuff tears, after a physical therapy treatment based on therapeutic exercise and education.

开始日期2024-05-01

申办/合作机构

Hospital Universitario Principe De Asturias

[+4]

NCT05909930 / RecruitingN/AIIT

Effectiveness of TheRApeutic ExercIse aNd EDucation on Patients With Massive Rotator Cuff Tears (the TRAINED Study): a Multicenter Non-controlled Trial

The aim of this multicenter non-controlled study will be to evaluate the effectiveness of a physical therapy treatment based on resistance exercise and education for patients with massive rotator cuff tears.

开始日期2024-05-01

申办/合作机构

Hospital Universitario Principe De Asturias

[+4]

100 项与 Hospital Universitario Principe De Asturias 相关的临床结果

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1,201

项与 Hospital Universitario Principe De Asturias 相关的文献（医药）

2024-10-01·Enfermedades infecciosas y microbiologia clinica (English ed.)

Recently acquired hepatitis C: Epidemiological characteristics and treatment response in a large cohort of MSM living with HIV in Madrid

Article

作者: Vivancos, María Jesús ; Sepúlveda-Crespo, Daniel ; Cano-Smith, Joanna ; Álvarez, Beatriz ; Sanz, José ; Berenguer, Juan ; Ryan, Pablo ; Rodríguez Martín, Carmen ; Resino, Salvador ; González-García, Juan ; Bisbal, Otilia ; González-Baeza, Alicia ; de Los Santos, Ignacio ; Palomar, Marina ; Martín-Carbonero, Luz ; Vergas, Jorge ; Gutierrez, Ángela

INTRODUCTIONWe analyzed epidemiological, clinical characteristics, and the response to treatment in people living with HIV (PLHIV) who recently acquired hepatitis C (RAHC) in a multicentre study in Madrid (Spain).METHODSMulticenter, ambispective, observational study of RAHC in men who have sex with men (MSM) infected with HIV. Clinical, epidemiological, and RAHC evolution were recorded prospectively in 2019 and 2020 and retrospectively in 2017 and 2018. In patients who received HCV treatment, sustained virological response (SVR) was provided 12 weeks after the end of treatment in an intention to treat analysis (ITT): all treated patients were included; and in analysis per-protocol (PP): missing patients were excluded.RESULTSOverall, 133 patients were included. Median (IQR) age was 40 (34.3-46.1) years, 90.9% had at least one previous sexual transmission disease (STD), and 33.6% had previously hepatitis C. More than half of the prospective sample included patients using chemsex related drugs (57.3%), 45.7% of them intravenously. The most prevalent genotype was G1a (66.2%), followed by G4 (11.3%). Ten of 90 patients evaluated for spontaneous cure (11%) cured the infection spontaneously, and 119 had treatment after a median time of 1.8 (0.7-4.6) months: sustained virological response (SVR) was achieved in 90.7% in the ITT and 94.7% in the PP analysis, with no differences regarding the direct-acting antiviral agents (DAA) combination used.CONCLUSIONSMSM infected by HIV with a RAHC were exposed to high-risk sexual behavior. Spontaneous cure rate was low, while SVR after treatment was achieved by more than 90%.

2024-10-01·Revista Española de Cardiología (English Edition)

Valvulitis: a new echocardiographic criterion for the diagnosis of bioprosthetic aortic valve infective endocarditis

Article

作者: Islas, Fabián ; Pérez-García, Carlos Nicolás ; Montero, Lourdes ; de Agustín, José Alberto ; Saiz-Pardo, Melchor ; Zulet, Pablo ; Gómez, Daniel ; Carnero, Manuel ; Olmos, Carmen ; Mahía, Patricia ; Pérez-Camargo, Daniel ; San Román, José Alberto ; Pozo, Eduardo ; García-Arribas, Daniel ; Vilacosta, Isidre ; Jerónimo, Adrián

INTRODUCTION AND OBJECTIVESDiffuse homogeneous hypoechoic leaflet thickening, with a wavy leaflet motion documented by transesophageal echocardiography (TEE), has been described in some cases of prosthetic valve endocarditis (PVE) involving aortic bioprosthesis (AoBio-PVE). This echocardiographic finding has been termed valvulitis. We aimed to estimate the prevalence of valvulitis, precisely describe its echocardiographic characteristics, and determine their clinical significance in patients with AoBio-PVE.METHODSFrom 2011 to 2022, 388 consecutive patients with infective endocarditis (IE) admitted to a tertiary care hospital were prospectively included in a multipurpose database. For this study, all patients with AoBio-PVE (n=86) were selected, and their TEE images were thoroughly evaluated by 3 independent cardiologists to identify all cases of valvulitis.RESULTSThe prevalence of isolated valvulitis was 12.8%, and 20.9% of patients had valvulitis accompanied by other classic echocardiographic findings of IE. A total of 9 out of 11 patients with isolated valvulitis had significant valve stenosis, whereas significant aortic valve regurgitation was documented in only 1 patient. Compared with the other patients with AoBio-PVE, cardiac surgery was less frequently performed in patients with isolated valvulitis (27.3% vs 62.7%, P=.017). In 4 out of 5 patients with valve stenosis who did not undergo surgery but underwent follow-up TEE, valve gradients significantly improved with appropriate antibiotic therapy.CONCLUSIONSValvulitis can be the only echocardiographic finding in infected AoBio and needs to be identified by imaging specialists for early diagnosis. However, this entity is a diagnostic challenge and additional imaging techniques might be required to confirm the diagnosis. Larger series are needed.

2024-06-01·Ophthalmology Retina

European Unmet Needs in the Management of Neovascular Age-Related Macular Degeneration in Daily Practice

Article

作者: Barthelmes, Daniel ; Boudousq, Clotilde ; Schmidt-Erfurdt, Ursula ; Nguyen, Vuong ; Gillies, Mark ; Kusenda, Pavol ; Vujosevic, Stela ; Kheir, Wajiha Jurdi ; Gabrielle, Pierre-Henry ; Arruabarrena, Carolina ; O'Toole, Louise ; Pollreisz, Andreas ; Mangelschots, Els ; Zarranz-Ventura, Javier ; Creuzot-Garcher, Catherine ; Hunt, Adrian

PURPOSETo evaluate the proportion, predictors, and outcomes of patients with neovascular age-related macular degeneration (nAMD) treated with a high burden of VEGF inhibitor intravitreal (IVT) injections after 2 years in routine clinical practice.DESIGNRetrospective analysis of data from a prospectively designed observational outcomes registry, the Fight Retinal Blindness! Project, of patients treated in European centers.PARTICIPANTSTreatment-naïve eyes (1 eye per patient) starting VEGF inhibitors for nAMD from January 2017 to March 2020 with 24 months of follow-up. We analyzed the following 3 treatment-burden groups defined by the mean interval of the 3 closest injections to the 24-month visit: (1) those with a high-treatment burden had injection intervals ≤ 42 days, (2) those with a low-treatment burden had injection intervals between 43 and 83 days; and (3) those with tolerable treatment burden had injection intervals between 84 and 365 days.METHODSMultinomial regression was used to evaluate baseline risk predictors of patients requiring a high-treatment burden.MAIN OUTCOME MEASURESThe proportion of patients that experienced a high-treatment burden at 2 years and its predictors.RESULTSWe identified 2038 eligible patients completing 2 years of treatment (2038/3943 patients [60%]) with a median (quartile 1, quartile 3) of 13 (10, 17) injections. The proportion of patients with a high-treatment burden was 25% (516 patients) at 2 years. Younger patients (odds ratio [OR], 0.97; 95% confidence interval [CI], 0.96-0.99; P < 0.01) were more likely to have high-treatment burden, whereas eyes with type 3 choroidal neovascular lesions at baseline were significantly less likely (OR, 0.26; 95% CI, 0.13-0.52; P < 0.01). Regarding type of fluid, patients with subretinal fluid only at baseline (OR, 3.85; 95% CI, 1.34-11.01; P = 0.01) and persistent active intraretinal (OR, 1.56; 95% CI, 1.18-2.06; P < 0.01) or subretinal fluid only (OR, 2.21; 95% CI, 1.52-3.21; P < 0.01) after the loading phase had a higher risk of high treatment burden at 2 years.CONCLUSIONSHigh treatment burden is a common issue in routine clinical practice in Europe, with a quarter of patients requiring injections of conventional VEGF inhibitors every 6 weeks at 2 years and 40% discontinuing treatment within 2 years.FINANCIAL DISCLOSURE(S)Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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100 项与 Hospital Universitario Principe De Asturias 相关的转化医学

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