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8

项与 St. Patrick's University Hospital 相关的临床试验

NCT04082858

/ Terminated临床1期IIT

Ketamine Interleaved With Electroconvulsive Therapy for Depression, A Pragmatic Randomised Controlled Pilot Trial

Pragmatic, randomised, controlled, parallel group, pilot clinical trial of ketamine vs. midazolam interleaved with electroconvulsive therapy (ECT) as an adjunctive treatment for a major depressive episode. The main purpose of the pilot study is to assess trial processes to help inform a future definitive trial.

开始日期2020-01-06

申办/合作机构

St. Patrick's University Hospital

NCT03256162

/ Completed临床1期IIT

Ketamine as an Adjunctive Therapy for Major Depression - a Randomised Controlled Pilot Trial: The KARMA-Dep Trial

Randomised, controlled, parallel-group, pilot clinical trial of ketamine vs. midazolam as an adjunctive therapy for depression. The main purpose of the pilot study is to assess trial processes to help inform a future definitive trial.

开始日期2017-09-07

申办/合作机构

St. Patrick's University Hospital

NCT03396887

/ Unknown statusN/AIIT

The Effectiveness of a Smartphone Application in the Treatment of Alcohol Use Disorder

Alcohol dependence poses a major problem for Irish and UK society, placing a huge burden on the health system. It is difficult to treat and relapse is common. There is an urgent need to develop novel treatment methods. One growing area of intervention is the use of mobile phone technology to develop personalised, patient-centred treatments. These can be used in outpatient settings, allowing patients to manage their own illness and take control of their recovery. In this study the investigators will investigate how a smartphone application, UControlDrink, can help alcoholics stay abstinent from alcohol. The application consists of a number of features known to aid recovery such as supportive messages and online therapy.

开始日期2017-05-01

申办/合作机构

St. Patrick's University Hospital

100 项与 St. Patrick's University Hospital 相关的临床结果

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0 项与 St. Patrick's University Hospital 相关的专利（医药）

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135

项与 St. Patrick's University Hospital 相关的文献（医药）

2025-06-01·Journal of Affective Disorders

Expression of concern re: Shi, Z.-M. et al. Intravenous ketamine versus electroconvulsive therapy for major depressive disorder or bipolar depression: A meta-analysis of randomized controlled trials. J. Affect. Disord. (2024) doi:10.1016/j.jad.2024.11.034

Letter

作者: Jelovac, Ana ; McLoughlin, Declan M

2025-05-01·BJPsych Open

Retrograde amnesia following electroconvulsive therapy for depression: propensity score analysis

Article

作者: Gusciute, Gabriele ; Jelovac, Ana ; Doody, Eimear ; Landau, Sabine ; McDonagh, Kelly ; McLoughlin, Declan M ; Carton, Mary ; McCaffrey, Cathal ; Kavanagh, Keeva ; Noone, Martha

SummaryRetrograde amnesia for autobiographical memories is a commonly self-reported cognitive side-effect of electroconvulsive therapy (ECT), but it is unclear to what extent objective performance differs between ECT-exposed and ECT-unexposed patients with depression. We investigated the association between exposure to brief-pulse (1.0 ms) bitemporal or high-dose right unilateral ECT and retrograde amnesia at short- and long-term follow-up, compared with inpatient controls with moderate-to-severe depression without lifetime exposure to ECT and receiving psychotropic pharmacotherapy and other aspects of routine inpatient care. In propensity score analyses, statistically significant reductions in autobiographical memory recall consistency were found in bitemporal and high-dose right unilateral ECT within days of an ECT course and 3 months following final ECT session. The reduction in autobiographical memory consistency was substantially more pronounced in bitemporal ECT. Retrograde amnesia for items recalled before ECT occurs with commonly utilised ECT techniques, and may be a persisting adverse cognitive effect of ECT.

2025-03-01·Neuroscience & Biobehavioral Reviews

Inflammatory markers associated with electroconvulsive therapy response in patients with depression: A meta-analysis

Review

作者: van Exel, Eric ; Belge, Jean-Baptiste ; Vanderhaegen, Gertjan ; Dellink, Annelies ; Kruse, Jennifer ; Coppens, Violette ; van Diermen, Linda ; Morrens, Manuel ; Ryan, Karen M ; McLoughlin, Declan M ; Aarsland, Tore Ivar Malmei

Electroconvulsive therapy (ECT) is an effective intervention for severe unipolar and bipolar depression, yet its drawbacks often lead to its underutilization. Accurate prediction of ECT outcomes is crucial for optimizing patient care and increasing remission rates. This study synthesized existing evidence on the relationship between baseline inflammatory markers and ECT outcomes. Additionally, we explored whether changes in these markers during ECT correlated with symptom improvement. A correlation meta-analysis was conducted according to the PRISMA statement, including a total of fourteen studies (n = 556 patients). The analyses revealed that higher baseline CRP and IL-6 levels were significantly associated with greater depressive symptom reduction post-ECT. Additionally, our findings suggested that increases in kynurenine metabolites and IL-8 during treatment correlated with improved depressive symptoms, offering insights into the mechanistic aspects of depression and ECT. In conclusion, peripheral inflammation in depression, as measured by CRP and IL-6, is associated with better ECT outcomes and may guide treatment stratification. Further research on a broader range of cytokines and kynurenine metabolites is needed to confirm these findings.

100 项与 St. Patrick's University Hospital 相关的药物交易

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100 项与 St. Patrick's University Hospital 相关的转化医学

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