Delving into the Latest Updates on Cleveland Clinic Avon Hospital with Synapse

概览

疾病领域	数量

肿瘤	2

排名前五的药物类型	数量

小分子化药	1
多肽偶联药物（PDC）	1

排名前五的靶点	数量

FAK x NANOG	1
核糖核苷酸还原酶复合体	1

关联

2

项与 Cleveland Clinic Avon Hospital 相关的药物

aCx26-pep

靶点

FAK x NANOG

作用机制

FAK抑制剂 [+1]

在研机构

Cleveland Clinic Avon Hospital

原研机构-

在研适应症

三阴性乳腺癌

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

TMU27a

靶点

核糖核苷酸还原酶复合体

作用机制

RNR抑制剂

在研机构

Case Western Reserve University [+1]

原研机构

Cleveland Clinic Avon Hospital [+1]

在研适应症

三阴性乳腺癌

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Cleveland Clinic Avon Hospital 相关的临床结果

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0 项与 Cleveland Clinic Avon Hospital 相关的专利（医药）

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4

项与 Cleveland Clinic Avon Hospital 相关的文献（医药）

2022-11-01·Annals of Internal Medicine: Clinical Cases

A Case Report of Postheart Transplant Epicardial Adipose Deposition in a Patient With Dunnigan Syndrome

作者: Rao, Roopa A. ; Damera, Nihanth ; Bajpai, Vatsal ; Bateman, Pantila ; Oral, Elif ; Pattisapu, Anish

2020-01-01·Critical Care Medicine

139: EVALUATION OF INHALED VASODILATOR USE IN PATIENTS WITH POSTOPERATIVE PULMONARY HYPERTENSION

作者: Marut, Danielle ; Lytle, Francis ; Popa, Andreea ; Hoffman, Lindsey ; Bush, Weston

2019-10-23·Open Forum Infectious Diseases

993. Pharmacist-driven Penicillin Allergy Assessment in the Emergency Department – Antimicrobial Stewardship at the Point of Prescription

作者: Immler, Ellen ; Dandache, Patricia ; Campbell, Samantha ; Srinivas, Pavithra ; Seiti, Susan ; Hauler, Gregory

AbstractBackgroundΒ-lactam allergy assessment is endorsed by the IDSA as an antimicrobial stewardship tool to enhance the use of first-line agents. We evaluated the impact of pharmacist-driven penicillin (PCN) allergy assessment at the point of prescription on antibiotic use in our emergency department (ED).MethodsRetrospective, quasi-experimental study of adult patients with a PCN allergy receiving antibiotics at a community hospital ED. The intervention comprised an ED pharmacist performing allergy assessment and discussing therapy options with providers at the point of prescription. The primary outcome was to evaluate impact on guideline-preferred antibiotic prescription in the ED pre-intervention (March 1, 2017–August 31, 2017) vs. post-intervention (March 1, 2018–August 31, 2018). Secondary outcomes included types of reported allergic reactions, safety of allergy assessment process, and impact on downstream antibiotic use.ResultsOverall, 381 patients were evaluated (256 pre-intervention, 125 post-intervention). The median age was similar between groups and 85% of patients presented to the ED from the community. Most common infectious syndromes encountered in the ED were UTIs (35%), respiratory tract infections (25%), and skin/soft-tissue infections (18%). The proportion of guideline-preferred antibiotic prescriptions in the ED increased from 37% pre to 44% post (P = 0.171). Proportion of fluoroquinolone (FQ) prescriptions in the ED was reduced from 37.5% pre to 26% post (P = 0.021). Proportion of cephalosporin prescriptions increased from 26% pre to 42% post (P = 0.002). Types of reported allergic reactions were similar between groups and 55% of patients had tolerated a β-lactam agent since the listed allergy. Overall, 70% of patients were hospitalized from the ED. Similar trends in antibiotic use were observed at admission – decreased FQs (38% pre vs. 27% post, P = 0.059), increased cephalosporins (24% pre vs. 38.4% post, P = 0.021). Two patients (1.6%) experienced a nonsevere reaction within 24 hours of β-lactam administration post-allergy assessment.ConclusionPharmacist-driven PCN allergy assessment at the point of prescription in the ED was safe and effective at improving the use of guideline-preferred antibiotics and reducing FQ use.DisclosuresAll authors: No reported disclosures.

100 项与 Cleveland Clinic Avon Hospital 相关的药物交易

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100 项与 Cleveland Clinic Avon Hospital 相关的转化医学

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