Barriers and Challenges of Loss to follow up, the healthcare utilization pattern, and healthcare expenditure among patients seeking treatment for hypertension at a tertiary care hospital A Mixed Method Study. - NIL

开始日期2025-02-01

申办/合作机构

Manipal college of Medical Sciences

CTRI/2024/09/073516 / Recruiting临床4期IIT

Efficacy & safety of topical Lidocaine and Prilocaine gel for arteriovenous fistula cannulation pain in hemodialysis patients A Crossover Randomized Control Trial - NIL

开始日期2024-09-24

申办/合作机构

Manipal college of Medical Sciences

CTRI/2024/08/072179 / Not yet recruitingN/AIIT

Optimization and Application of Hybrid Intravoxel Incoherent Motion – Diffusion Kurtosis Imaging in the Evaluation of Brain Tumours

开始日期2024-09-07

申办/合作机构

Manipal college of Medical Sciences

100 项与 Manipal college of Medical Sciences 相关的临床结果

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0 项与 Manipal college of Medical Sciences 相关的专利（医药）

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1,046

项与 Manipal college of Medical Sciences 相关的文献（医药）

2024-12-01·Non-coding RNA Research

Evaluation of circulating plasma miR-9, miR-29a, miR-192, and miR-375 as potential biomarkers for predicting prediabetes and type 2 diabetes in Nepali adult population

Article

作者: Manandhar, Binod ; Manandhar, Krishna Das ; Raut, Roji ; Dahal, Prajwal ; Pokharel, Daya Ram ; Adhikari, Shailesh ; Maskey, Abhishek ; Batajoo, Ashim ; Kafle, Ramchandra

Circulating plasma miRNAs have emerged as potential early predictors of glucometabolic disorders. However, their biomarker potential remains unvalidated in populations with diverse genetic backgrounds, races, and ethnicities. This study aims to validate the biomarker potential of plasma miR-9, miR-29a, miR-192, and miR-375 for early detection of prediabetes and type 2 diabetes mellitus (T2DM) in Nepali populations that represent distinct genetic backgrounds, races, and ethnicities. A total of 46 adults, categorized into healthy controls (n = 25), prediabetes (n = 9), and T2DM (n = 12) groups, were enrolled. Baseline sociodemographic, anthropometric, and clinical characteristics were collected. Fold change in plasma expression of all four miRNAs was quantified using RT-qPCR against the RNU6B reference gene. Their biomarker potential was determined by receiver operating characteristic (ROC) curve analysis. Multivariate discriminant function and hierarchical cluster analyses were used to evaluate the effectiveness of the miRNA panel in reclassifying study participants who were initially categorized according to their glucose tolerance status. Plasma expression of all four miRNAs was significantly upregulated in T2DM patients compared to normoglycemic controls. Furthermore, the expression of only miR-29a and miR-375 was upregulated in T2DM patients than in prediabetic individuals. Notably, only miR-192 expression was significantly upregulated in prediabetic individuals than in the normoglycemic controls. The miRNA expression profiles had the potential of reclassifying the participants into three original groups with an accuracy of 69.6 %. ROC curve analysis identified miR-192 as the predictor for both prediabetes and T2DM, while miR-9, miR-29a, miR-192, and miR-375 were predictive only for T2DM. The specific set of miRNA combinations significantly improved their predictive accuracy. This study validates the early predictive biomarker potential of plasma miR-9, miR-29a, miR-192, and miR-375 also in the Nepali population and paves the way for future translational studies to validate their utility in clinical laboratories.

2024-10-01·International Journal of Surgery Case Reports

Ileal perforation peritonitis secondary to accidental ingestion of a chicken bone: A case report

Article

作者: Neupane, Bhoj Raj ; Panday, Bijay ; Bhatta, Om Prakash ; Gyawali, Prakash ; Joshi, Mandeep Dutta ; Dangol, Rojan Singh

INTRODUCTION AND IMPORTANCEIleal perforation is a rare but serious condition that can arise from accidental ingestion of foreign objects. This report discusses an unusual case of ileal perforation peritonitis caused by ingestion of a chicken bone.CASE PRESENTATIONA 60-year-old male presented with acute generalized abdominal pain, fever, nausea, and vomiting for three days. A physical examination revealed signs of peritonitis. Imaging results were unremarkable. Emergency laparotomy revealed perforation in the ileum caused by the chicken bone. The perforated segment was resected, and primary anastomosis was performed.CLINICAL DISCUSSIONIngestion of foreign bodies, although common, rarely leads to gastrointestinal perforations. Among these foreign bodies, chicken bones are rarely reported, making the diagnosis challenging because of nonspecific symptoms and low clinical suspicion. Prompt surgical intervention is crucial for managing complications such as peritonitis and sepsis.CONCLUSIONThis case highlights the importance of considering foreign body ingestion in the differential diagnosis of acute abdominal pain, particularly in patients without an obvious cause of peritonitis. Early detection and timely surgical intervention are essential to improve patient outcomes.

2024-09-06·Medicine

Safety and efficacy of S1P receptor modulators for the induction and maintenance phases in inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled trials.

Review

作者: Aslam, Uzma ; Kaleem, Shamama ; Furqan, Humam ; Omer, Areeb ; Akram, Abdullah ; Khan, Ali Tahir ; Tahir, Muhammad Abdullah ; Bhattarai, Pratik ; Memon, Saria ; Anjum, Muhammad Umair ; Ahmed, Misha ; Karam, Ayatul ; Farhan, Kanza

BACKGROUNDInflammatory bowel disease (IBD) is a chronic inflammatory condition that significantly affects quality of life. Conventional treatments have had limited success. this study evaluates the safety and efficacy of Sphingosine 1-phosphate receptor modulators (S1PrMs) as a potential treatment for IBD.METHODSWe conducted a thorough search of published literature on PubMed, EMBASE, and Google Scholar from 2000 to 2023. The inclusion criteria were randomized controlled trials (RCTs) with a target population comprising of IBD patients receiving either S1PrMs or placebo and a comparison of the 2. The statistical analysis was conducted using RevMan (version 5.4). Forest plots presented the results as risk ratios (RR) with a 95% confidence interval.RESULTSA total of 7 RCTs involving 2471 patients were included. The results were reported for both the induction and maintenance phases of treatment. in the induction phase, the intervention group proved to have a significantly higher incidence of histological remission (RR = 2.67; 95% CI [1.97, 3.60]; P < .00001), endoscopic improvement (RR = 2.06; 95% CI [1.66, 2.56]; P < .00001), clinical remission (RR = 2.23; 95% CI [1.43, 3.46]; P < .0004) and clinical response (RR = 1.37; 95% CI [1.01, 1.84]; P = .04) compared to the placebo group. Outcomes assessed in maintenance phase significantly favored the intervention group over placebo as well, histologic remission (RR = 2.39; 95% CI [1.83, 3.11]; P < .00001), endoscopic improvement (RR = 2.20; 95% CI [1.28, 3.77]; P = .004), clinical remission (RR = 3.03; 95% CI [1.84, 4.99]; P < .0001), and clinical response (RR = 1.74; 95% CI [1.25, 2.42]; P = .001).CONCLUSIONS1PrMs show promising potential for establishing histologic remission, endoscopic improvement, clinical remission, and corticosteroid-free clinical remission. With more studies and clinical trials, these modulators may become a reliable therapeutic choice for UC patients everywhere.

100 项与 Manipal college of Medical Sciences 相关的药物交易

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100 项与 Manipal college of Medical Sciences 相关的转化医学

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