Respiratory physiotherapy is routinely performed after thoracic surgery operations to increase lung expansion and prevent pulmonary complications such as atelectasis and pneumonia. It is a controversial issue whether respiratory physiotherapy reduces pulmonary complications in rib fractures. In our study, patients with rib fractures will be divided into two groups. In the control group, standard treatment consisting of routine analgesic treatments will be applied. In the other group, respiratory physiotherapy will be applied with triflu for 8 hours a day. At the end of the study, pulmonary complications in both groups will be compared.

开始日期2024-11-01

申办/合作机构

Kastamonu University

NCT06535100 / RecruitingN/AIIT

Strong Mother Strong Special Individual

Special needs individuals with mental disabilities and other special conditions accompanying mental needs (hearing disability, visual disability, physical disability, autism spectrum disorder, multiple disabilities, language and speech disorder, learning disability and emotional/behavioral disorder) are diagnosed with special needs individuals. It includes mothers who are in service. Caregivers of children with mental special needs may experience mental problems such as anxiety, hopelessness and depression, which negatively affects the caregiver's mental resilience and increases their care burden. In order to reduce the care burden, artistic activities will be organized to express the emotions of caregivers.

开始日期2024-06-03

申办/合作机构

Kastamonu University

[+1]

NCT06627400 / CompletedN/AIIT

Association of Urinary Incontinence With Depression, Insomnia, Frailty and Falls in Older Adults: a Cross-sectional Comprehensive Geriatric Assessment

The aim of our study is to provide a holistic analysis of the geriatric syndromes associated with urinary incontinence, which can result in significant adverse outcomes in the elderly, and to explore the gender-specific relationships within these associations. The study revealed that urinary incontinence is highly prevalent among the older adults, particularly in women, and is associated strongly with depression, insomnia, frailty, and falls. Moreover, while older women with urinary incontinence exhibited more depressive symptoms than men, urinary incontinence was associated with similar frequencies of insomnia in both sexes. Considering the negative outcomes of depression, insomnia, frailty, and falls in older adults, as well as a decline in functionality, cognitive impairment, and prolonged hospitalizations and even mortality they cause, it becomes evident that urinary incontinence must be routinely assessed and treated by clinicians.

开始日期2024-06-01

申办/合作机构

Kastamonu University

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2024-12-31·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Estimation of landfill gas emissions at the solid waste disposal site of low-population regions with LandGEM and tabasaran–rettenberger mathematical models

作者: Ozata, Suha ; Degermenci, Gokce Didar

In developing countries, solid waste most commonly ultimately ends up is landfill.Landfill sites release significant amounts of air pollutants, such as methane (CH₄) and carbon dioxide.It is thus important to reduce, control, and recycle these gases.In this study, we aimed to calculate gas emissions and energy production from landfill sites serving low-population areas.Future landfill gas production was estimated using LandGEM and Tabasaran - Rettenberger models, based on population and waste volume predictions.In both models, total amount of landfill gas and CH₄ produced reached their highest values in 2035.According to the LandGEM model, this will amount to 11,230 and 3,179 Mg/yr, resp., while the Tabasaran - Rettenberger model predicted 14,986 and 4,014 Mg/yr, resp.The volume of landfill gas calculated using the Tabasaran - Rettenberger model was 3.730 million m³/yr for 2021, while this was 2.544 million m³/yr using the LandGEM model.In 2021, 84007 Mg of waste was disposed of at the landfill site.According to data from the electricity generation plant at the site, the elec. energy generated in 2021 was 5,309 kWh.Comparing the results from these two models with actual landfill data, the Tabasaran - Rettenberger model came closest to the estimateTherefore, the Tabasaran - Rettenberger model can be used to estimate the potential for gas production at landfill sites in cities with similar waste components.

2024-12-01·Molecular Biology Reports

Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells

Article

作者: Gıdık, Betül ; Dirican, Ebubekir ; Çınar, İrfan

BACKGROUNDThis study aimed to investigate the cytotoxic, apoptotic, invasion, metastasis, and heat shock proteins (HSPs) effects of N. sativa oil on breast and gastric cancer cells.METHODSWe assessed the cytotoxic and apoptotic effects of various concentrations of N. sativa oil (10-50-100-200 µg/mL) on MCF7 breast cancer and AGS, an adenocarcinoma of the gastric cell line, at 24, 48 and 72 h using the MTT test. Additionally, the expression of the Caspase-3, BCL2/Bax, MMP2-9 and HSP60-70 gene was examined using RT-PCR in cell lines treating with N. sativa.RESULTSThe MTT experiments demonstrate that N. sativa has a time and dose-dependent inhibitory effect on the proliferation of MCF7 and AGS cancer cells. The vitality rates of MCF7 and AGS cells treated with N. sativa were 77.04-67.50% at 24 h, 65.28-39.14% at 48 h, and 48.95-32.31% at 72 h. The doses of 100 and 200 µg/mL were shown to be the most effective on both cancer cells. RT-PCR analysis revealed that N. sativa oil extract increased caspase-3 levels in both cell lines at higher concentrations and suppressed BCL2/Bax levels. Exposure of MCF7 and AGS cell lines to N. sativa caused a significant decrease in the expression of MMP2-9 and HSP60-70 genes over time, particularly at a dosage of 200 µg/mL compared to the control group (p < 0.05).CONCLUSIONSOur findings indicate that N. sativa oil has a dose-dependent effect on cytotoxicity and the expression of apoptotic, heat shock proteins, and matrix metalloproteinases genes in breast and gastric cancer.

2024-12-01·Journal of Forestry Research

Ecoregional height–diameter models for Scots pine in Turkiye

作者: Sakici, Oytun Emre ; Saglam, Fadime

AbstractEcoregion-based height-diameter models were developed in the present study for Scots pine (Pinus sylvestris L.) stands in Turkiye and included several ecological factors derived from a pre-existing ecoregional classification system. The data were obtained from 2831 sample trees in 292 sample plots. Ten generalized height–diameter models were developed, and the best model (HD10) was selected according to statistical criteria. Then, nonlinear mixed-effects modeling was applied to the best model. The R2 for the generalized height‒diameter model (Richards function) modified by Sharma and Parton is 0.951, and the final model included number of trees, dominant height, and diameter at breast height, with a random parameter associated with each ecoregion attached to the inverse of the mean basal area. The full model predictions using the nonlinear mixed-effects model and the reduced model (HD10) predictions were compared using the nonlinear sum of extra squares test, which revealed significant differences between ecoregions; ecoregion-based height–diameter models were thus found to be suitable to use. In addition, using these models in appropriate ecoregions was very important for achieving reliable predictions with low prediction errors.

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