Delving into the Latest Updates on Kermanshah University of Medical Sciences with Synapse

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疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

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1

项与 Kermanshah University of Medical Sciences 相关的药物

Terpin Hydrate

萜品醇

靶点-

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在研机构

Kermanshah University of Medical Sciences

原研机构-

在研适应症

咳嗽 [+2]

非在研适应症-

最高研发阶段批准上市

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首次获批日期-

606

项与 Kermanshah University of Medical Sciences 相关的临床试验

IRCT20130812014333N92 / Suspended临床1/2期IIT

Investigation of transaxic acid effect on treatment of admitted patients due to upper gastrointestinal bleeding

开始日期2638-03-23

申办/合作机构

Kermanshah University of Medical Sciences

IRCT20130812014333N228 / Suspended临床2/3期IIT

Investigating the effect of intramucosal injection of exosomes derived from umbilical cord mesenchymal stem cells on the treatment of chronic rhinosinusitis with polyposis

开始日期2024-10-21

申办/合作机构

Kermanshah University of Medical Sciences

IRCT20130812014333N227 / RecruitingN/AIIT

Comparative study of efficacy and side effects of Avisirox and Nanojade in thalassemia patients

开始日期2024-10-06

申办/合作机构

Kermanshah University of Medical Sciences

100 项与 Kermanshah University of Medical Sciences 相关的临床结果

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0 项与 Kermanshah University of Medical Sciences 相关的专利（医药）

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12,579

项与 Kermanshah University of Medical Sciences 相关的文献（医药）

2025-02-01·Current Nutrition & Food Science

Potential of Fat Replacers To Develop Low/Or Reduced-Fat Mayonnaise and Salad Dressing Systems: An Updated Review

作者: azadinejad, hossein ; Afrah, Arvin ; Azadinejad, Hossein ; Hosseini, Asad ; Abedi-Firoozjah, Reza ; abdolmaleki, khadije

Abstract:Mayonnaise is one of the most popular seasonings and well-established sauces globally, which is considered a high-fat and high-calorie product due to its high oil content. However, excessive consumption of fat (especially saturated fatty acids) leads to an increased risk of various chronic diseases including cardiovascular disease, coronary artery disease, type 2 diabetes, Covid-19, and obesity. Therefore, the demand for low-fat, low-calorie food products is increasing. Fat replacers (FR) have recently been employed to decrease fat content while ensuring consumer acceptability. Production of low-fat mayonnaise without significant quality changes is challenging from an industrial point of view. In this review, the fat replacement approach in the low/or reduced-fat mayonnaise and salad dressing systems is conferred in various aspects, including functional, technological, and sensorial properties. The type and source of used FRs, their benefits and drawbacks, and their nutritional effects are also discussed. Due to the unique functional role of fat, the development of low-fat dressing products that meet consumer demands is more complex than those provided by FRs. Also, although fat and calories are effectively reduced, due to the lack of human intervention studies, future research should focus on the safety of these fat substitutes.

2025-01-01·Journal of Molecular Structure

Mechanistic investigation of the cytotoxicity of new Ce(IV) and Zn(II) complexes containing pyridinedicarboxylic acid derivatives against the SW480 cell line

作者: Aliabadi, Alireza ; Abdolmaleki, Sara ; Khaksar, Samad

Two cerium(IV) (C1) and zinc(II) (C2) complexes formulated as (aeea)₂[Ce(pydc)₃].5H₂O (where pydc is pyridine-2,6-dicarboxylate and aeea is aminoethylethanolamine) and [Zn(hpydc)(dmp)].2H₂O (where hpydc is 4-hydroxy-pyridine-2,6-dicarboxylate and dmp is 2,9-dimethyl-1,10-phenanthroline) were obtained by a one-pot reaction of organic ligands and the metal salts Ce(NO₃)₂.6H₂O and Zn(NO₃)₂.6H₂O.The complexes were characterized by spectroscopic methods and single-crystal X-ray diffraction.The MTT assay was performed for the compounds against four cell lines, including human hepatocellular carcinoma (BEL-7404), primary human colon cancer (SW480), metastatic human colon cancer (SW620) and normal human colon tissue (CCD841CoN), which showed the highest sensitivity to C1 (IC₅₀= 1.89 μM, MAE= 72.46%) (where MAE represents the maximal antiproliferative effect).C1 demonstrated its ability as a redox-active compound to generate high levels of reactive oxygen species (ROS) in this cell line.Mechanistic investigation of the efficacy of the compounds on SW480 cells showed that C1 can induce bimodal cell death by both (intrinsic and extrinsic) apoptosis and autophagy, whereas only the intrinsic apoptosis pathway was detected when the aforementioned cells were treated with C2.SW480 cells treated with C1 showed remarkable morphol. changes as well as a reduction in tumor size in the SW480 3D spheroid model.

2025-01-01·Current Nutrition & Food Science

Prevalence and Pattern of Dietary Supplement Use in Bodybuilding Athletes

作者: Abdollahzad, Hadi ; Daryoushi, Hooman ; Soroush, Ali ; Naghibifar, Zahra ; Kordloo, Yashar ; Baharirad, Nadya ; Nouri, Roghayeh ; Naghipour, Armin

Introduction:Using sports supplements is a common strategy for improving athletic performance. The prevalence of using sports supplements among adolescent and young athletes has been increasing in recent years.Methods:This descriptive-analytical study was performed on 200 bodybuilding athletes. The data collection tool was a pre-made questionnaire. The questionnaire was distributed among the athletes by available methods and collected after filling out. The chi-square test, Fisher's exact test, and logistic regression model were used to analyze the data.Results:The prevalence of using sports supplements was 62.5% (n=125), with males accounting for 67.5% (n=135) of the consumers. Various forms of proteins (43.5%, n=87), vitamins (40.5%, n=81), and hormones (38.5%, n=77) were the most commonly recommended supplements by the coaches (58.4%, n=73) and other athletes (31.2%, n=9). The sports supplements have been considered to have no side effects by 16.8% (n=21) of the athletes; however, 19.2% (n=24) mentioned cardiac adverse events, and 13.6% (n=17) pointed to renal complications as potential consequences of supplement use. The results of statistical tests and a logistic regression model showed a statistically significant relationship between sex, age, education and income, and sports supplement use (p=0.001).Conclusion:According to the results of this current study, a significant proportion of bodybuilding athletes take sports supplements without being aware of the side effects. Therefore, it is necessary to develop an educational program to inform the population about the mechanism of action of supplements in the body and also educate athletes and coaches about the correct use, side effects, and irreversible consequences of improper supplements use.

100 项与 Kermanshah University of Medical Sciences 相关的药物交易

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100 项与 Kermanshah University of Medical Sciences 相关的转化医学

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