Delving into the Latest Updates on Kermanshah University of Medical Sciences with Synapse

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疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

关联

1

项与 Kermanshah University of Medical Sciences 相关的药物

Terpin Hydrate

萜品醇

靶点-

作用机制-

在研机构

Kermanshah University of Medical Sciences

原研机构-

在研适应症

咳嗽 [+2]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期-

615

项与 Kermanshah University of Medical Sciences 相关的临床试验

IRCT20130812014333N92

/ Suspended临床1/2期IIT

Investigation of transaxic acid effect on treatment of admitted patients due to upper gastrointestinal bleeding

开始日期2638-03-23

申办/合作机构

Kermanshah University of Medical Sciences

IRCT20241121063793N1

/ Suspended临床3期IIT

A comparative study of the effect of trazodone, melatonin and trazodone/melatonine in the treatment of sleep disorders following traumatic brain injury

开始日期2025-01-19

申办/合作机构

Kermanshah University of Medical Sciences

IRCT20180712040438N9

/ SuspendedN/AIIT

The Effects of Vitamin D and Selenium Supplementation, Alone and in Combination, on Glycemic Indices, Inflammatory Markers, Adipokines, and Metabolic Parameters in Patients with Type 2 Diabetes

开始日期2025-01-19

申办/合作机构

Kermanshah University of Medical Sciences

100 项与 Kermanshah University of Medical Sciences 相关的临床结果

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0 项与 Kermanshah University of Medical Sciences 相关的专利（医药）

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12,937

项与 Kermanshah University of Medical Sciences 相关的文献（医药）

2025-12-31·International Journal of Adolescence and Youth

The effect of educational intervention based on the theory of planned behaviour on promotion of traffic-safe behaviours in students

作者: Amirkhani, Mehdi ; Zarghamian, Mahshid ; Khani Jeihooni, Ali ; Arman, Ali ; Balaghi Inalu, Fatemeh ; Afzali Harsini, Pooyan

2025-12-31·The Journal of Maternal-Fetal & Neonatal Medicine

The association between iron supplementation during pregnancy and the risk of childhood leukemia: a meta-analysis of case-control studies

Review

作者: Dabir, Mahsa ; Pam, Pedram ; Ghoreishi, Zohreh ; Saba, Fakhredin ; Jamali, Mehrdad

OBJECTIVESAcute leukemia (AL) presents significant health challenges, particularly in children, and iron plays a critical role in cellular processes that could influence cancer development. The study was motivated by the need to clarify the potential role of iron supplementation during pregnancy in influencing the risk of developing childhood leukemia.MATERIALS AND METHODSThis meta-analysis adhered to PRISMA guidelines and systematically searched PubMed, Scopus, and Web of Science databases up to April 2024 for relevant observational studies. Inclusion criteria focused on case-control studies assessing the relationship between iron supplementation during pregnancy and leukemia risk, reporting odds ratios (ORs) with 95% confidence intervals (CIs). Data extraction and quality assessment were performed independently by two researchers using the Newcastle-Ottawa Scale (NOS). Statistical analysis involved calculating overall relative risk (RR) using a random-effects model and assessing heterogeneity through Cochran's Q test and the I² statistic. Publication bias was evaluated using Egger's and Begg's tests.RESULTSThe study analyzed data from 9 studies with 12 data sets involving a total of 4281 participants (2327 cases and 1954 controls). The findings indicated no significant association between iron supplementation during pregnancy and the overall risk of childhood leukemia (OR:1.01; 95% CI: 0.84-1.21, I2 = 63.2%). Also, no relationship was found between receiving iron supplements during pregnancy and the risk of AML (OR:1.01; 95% CI: 0.84-1.21, I2 = 56.6%) and ALL (OR:1.00; 95% CI: 0.81-1.24, I2 = 67.3%).CONCLUSIONThis study found no significant association between iron supplementation during pregnancy and AL risk among case-control studies. Further research is needed to explore the potential influence of genetic and environmental factors on this relationship.

2025-12-01·Molecular Biology Reports

Assessment of HJV and SMN1 gene expression levels in infertile men: laboratory and bioinformatic approaches

Article

作者: Mansouri, Kamran ; Yari, Kheirollah ; Pournaghi, Parimah ; Bouk, Sasan ; Soleymani, Bijan

INTRODUCTION AND OBJECTIVESInfertility is a complex condition, with one of its key factors being the regulation of spermatogenesis, a process involving several critical genes. Previous in-silico studies have predicted a potential link between the HJV and SMN1 genes and spermatogenesis. This study aims to investigate the relationship between HJV and SMN1 gene expression in both blood and semen samples, and their association with male infertility, specifically azoospermia and oligospermia, through laboratory analysis. Furthermore, bioinformatic analyses were conducted to gain novel insights into these genes and, where applicable, to confirm their role in male infertility.METHODS AND RESULTSThe expression levels of HJV and SMN1 genes were analyzed using Real-Time PCR to compare differences between healthy and infertile groups. Additionally, to gain novel insights into the role of these genes in male infertility, we analyzed validated online datasets using R Studio with various packages, including Limma. Regarding the blood samples, the HJV gene mRNA was almost absent and the SMN1 gene expression level showed a significant decrease in infertile patients compared to healthy men. In the case of semen samples, real-time analysis showed a decreased expression of both genes in the samples of infertile patients. The in-silico analysis on the existing datasets showed the agreement of some data with the data of the present analysis.CONCLUSIONThe significant differences in HJV and SMN1 gene expression observed in the semen samples of healthy and infertile men suggest a potential connection between these genes and defects in the spermatogenesis process in these patients. While some datasets supported these findings, others did not show a significant relationship.

100 项与 Kermanshah University of Medical Sciences 相关的药物交易

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100 项与 Kermanshah University of Medical Sciences 相关的转化医学

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