A review. The authors describe their clin. observations from an urban, ambulatory COVID-19 clinic. In their clinic, patients with various combinations of mild symptoms, including nasal congestion, cough, sore throat, pleuritic chest pain, diarrhea, abdominal pain, headache, myalgias, back pain, and fatigue have tested pos. for SARS-CoV-2. They have also cared for many patients who experienced severe symptoms, including fever, cough, myalgias, and exhaustion, during the initial days of infection. Fever is common, but temperature elevations can be mild, particularly at the outset of illness. One of the only early hints to the diagnosis is loss of smell which many of our patients report losing during the first few days of illness. These initial days of SARS-CoV-2 infection are often indistinguishable from many common illnesses. A nuanced understanding of the typical presentation and natural history of COVID-19 in the ambulatory setting can help determine the appropriate timing of follow-up (patients who have begun to develop dyspnea should be followed closely in the following 72 h for evidence of worsening dyspnea particularly with exertion) and permit clinicians to more easily distinguish COVID-19 from other common and treatable illnesses.