Introduction and aim; Low functionality of respiratory muscles is frequently observed in various diseases such as chronic obstructive pulmonary disease, cystic fibrosis, idiopathic pulmonary fibrosis, and rheumatological diseases such as ankylosing spondylitis. Strengthening the respiratory muscles is a part of the treatment in such disease groups, and it has been reported that the quality of life of patients increases with the improvement in the respiratory muscles. Stavrou et al. In a study published in 2021, they achieved an increase in VO2max and maximum respiratory power in athletes after an exercise program with the AirOFit PRO™ (AirOFit, Copenhagen, Denmark) branded mobile breathing exercise device, which they introduced as a new technology. However, there is no study yet reporting the use of this device in rheumatological diseases.
The aim of this study is to investigate the effects of personalized breathing exercises with the AirOFit PRO™ (AirOFit, Copenhagen, Denmark) branded mobile breathing exercise device on respiratory muscles and functional exercise capacity, as well as on specific outcomes of the disease, in patients with ankylosing spondylitis.
Hypotheses of the study;
a) Hypothesis H1: Personalised breathing exercises applied with a mobile respiratory exercise device in patients with ankylosing spondylitis have a positive effect on respiratory capacity and activities of daily living in patients.

开始日期2024-11-05

申办/合作机构

Usak University

NCT06342193 / RecruitingN/AIIT

Effect of Virtual Reality Glasses on Anxiety During Cystoscopy: A Randomised Controlled Trial

The aim of this study was to investigate the effect of using virtual reality glasses as a distraction method on anxiety in men undergoing cystoscopy under local anaesthesia.

开始日期2024-03-14

申办/合作机构

Usak University

NCT06278805 / RecruitingN/AIIT

Adaptation and Validation Study of the Longer- Term Unmet Needs After Stroke Questionnaire Into Turkish

According to the most up-to-date knowledge, there is no Turkish comprehensive and validated instrument to assess stroke survivors' unmet needs in the longer term. So, this study aims to translate and adapt the LUNS into Turkish and examine its psychometric properties in survivors living at home after a stroke.
Our hypothesis in this study is:
- The Turkish Longer-term Unmet Needs after Stroke Questionnaire (T-LUNS) is a valid tool for assessing the unmet needs of stroke patients in the Turkish population.

开始日期2024-03-01

申办/合作机构

Usak University

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项与 Usak University 相关的文献（医药）

2024-11-01·International Journal of Polymeric Materials and Polymeric Biomaterials

Polyacrylonitrile (PAN)/carbon nanotube (CNT) electrospun nanofibers: synthesis, characterization, their biocompatibility for L929 fibroblast cells and molecular docking studies

作者: Mahaleh, Shayesteh Poorhosein Ghazi ; Mutlu, Dogukan ; Kara, Pinar ; Ince Yardimci, Atike ; Istifli, Erman Salih ; Liman, Recep ; Yagmurcukardes, Nesli ; Arslan, Sevki

There has been an important interest in to use of electrospun nanomaterials for tissue engineering applications due to the excellent scaffold-cell interaction provided by high interconnectivity and high porosity by electrospun nanofibers.In this study, Polyacrylonitrile (PAN) and carbon nanotube-inserted PAN (PAN/CNT) nanofibers were produced by the electrospinning method and characterized by SEM, FT-IR, and EIS spectroscopy.Both PAN and PAN/CNT nanofibers were obtained beadless and ordered with the average fiber diameters of 277.61 ± 43.6 and 171.01 ± 48.4, resp.The influence of CNT addition on PAN nanofibers was observed with the decrease of diameter and increase of elec. conductivity of nanofibers.Then, the biocompatibility of PAN and PAN/CNT nanofibers was evaluated by the MTT and AO/EB double-staining experimentsIt was observed that the nanofibers showed no cytotoxic effect on L929 fibroblast cells.In the docking experiments, while both PAN and PAN/CNT showed energetically favorable interactions (ΔG = -4.60 kcal/mol; -7.26 kcal/mol, resp.) with the membrane bilayer complex, PAN/CNT formed a more stable binding with the cellular membrane compared to PAN alone.Docking results mechanistically support the more effective increase in the proliferation of L929 fibroblasts at high concentrations in vitro, as PAN/CNT exhibits stronger binding affinity and interaction with the cellular membrane.The increase in elec. conductivity of nanofibers influenced the proliferation pos., as well.

2024-10-28·Acta Chromatographica

Evaluation of the RP-LC method for determining the pKa of abiraterone and its assay

作者: Paşa, Buket ; Şanlı, Senem ; Özdemir, Ayşe ; Şahin, Meryem Cansu

AbstractA straightforward, dependable, and quick RP-LC method for the analysis of abiraterone acetate in its dose form and human urine has been devised. With DAD detection, sensitivity was reported to be high. The LOD and LOQ of the procedure were deemed adequate. The suggested approach was exhaustively validated in accordance with ICH requirements, and the findings demonstrated that it was exact, accurate, selective, and sensitive for the analysis of this pharmaceutical. The chromatographic separation was realized using a X-Terra RP-18 (150 × 4.60 mm i.d. × 5 μm) column and a UV detector set at 255 and 267 nm. In addition, pKa values were calculated based on the relationship between the retention factor and the pH of the mobile phase. The influence of the composition of the mobile phase on the ionization constant was investigated by measuring the pKa at various acetonitrile–water combinations ranging from 50 to 70% (v/v).

2024-10-01·Journal of Molecular Liquids

Ecofriendly bleaching method for cotton fabric: Development of titanium dioxide doped single wall carbon nanocomposites by photocatalytic treatment for sustainable textile pre-finishing applications

作者: Ciğeroğlu, Zeynep ; Cigeroglu, Zeynep ; Omerogullari Basyigit, Zeynep

This study aimed to find an eco-friendly substitute method and chem. for conventional hydrogen peroxide (H₂O₂) bleaching of cotton fabric.We developed diverse functional groups containing titanium dioxide-doped single-wall carbon nanotubes (TiO₂-SWCNTs) particles, designed a photocatalytic system, and examined the effects of working conditions and functional group variations on the degree of fabric whitening.Throughout the many phases of the chem. development process, X-ray diffraction (XRD), Fourier transform IR spectroscopy -Attenuated total reflectance (FTIR-ATR) and the SEM (SEM) tests were conducted.In addition, the color spectrum values, the whiteness indexes, the results of the tearing test, SEM and FTIR-ATR findings of 100% cotton textiles were presented that were treated with TiO₂-SWCNTs particles using the photocatalytic technique.The test results demonstrated the successful synthesis of various types of TiO₂-SWCNTs, leading to a significant enhancement in the whiteness of the cotton fabrics.This increase reached 21.79% using a small amount of nano-chems., surpassing the whiteness index value created by the conventional H₂O₂ bleaching process.Optimal results were achieved by using min. quantities of substance and working at moderate temperaturesAccording to this information, it can be concluded that this approach may serve as a substitute for the conventional H₂O₂ whitening procedure in terms of both the substance utilized and the application method, specifically for treating cotton fabric.Moreover, the statistical anal. revealed that the fabric′s self-cleaning capacity is significantly influenced by the square of temperature and pH.

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