Micronuclear Frequency in Buccal Smear and its Correlation with Histopathological Dysplasia, p53 and p16 Expression in Oral Potentially Malignant Disorders and Squamous Cell Carcinoma - NIL

开始日期2024-11-07

申办/合作机构

Nil Ratan Sircar Medical College

CTRI/2024/07/070562 / Not yet recruiting临床3期

Efficacy of USG guided genicular nerve block with aqueous phenol(6%),ethyl alcohol(95%) and triamcinolone(20mg)with lignocaine(2%)-a randomized controlled trial. - NIL

开始日期2024-08-22

申办/合作机构

Nil Ratan Sircar Medical College

CTRI/2022/02/040047 / Not yet recruiting临床4期

Comparison Between Bupivacaine-Dexmedetomidine Versus Bupivacaine Alone In Erector Spinae Plane Block For Postoperative Analgesia After Modified Radical Mastectomy. A Prospective Comparative Study.

开始日期2022-02-15

申办/合作机构

Nil Ratan Sircar Medical College

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项与 Nil Ratan Sircar Medical College 相关的文献（医药）

2024-07-01·INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH

BIPHASIC SYNOVIAL SARCOMA OF ILIAC BLADE: APPROACH TO A RARE DISEASE

作者: Rai Choudhuri, Debarati ; Khan, Mantaj Ali ; Chowdhury, Rahul Bhanja

Introduction: Synovial sarcoma (SS) is a high-grade, rare variant of soft tissue sarcoma (STS). Synovial sarcoma accounts for only 5%-10% of all soft tissue sarcomas. It is a rare malignant type. The biphasic subtype is even lesser known than the monophasic subtype. SS is common around joint cavities in the extremities, but can be present elsewhere in the body. : Rare disease approach Aims & Objectives ,Multi-disciplinary treatment, To assess post-operative radiotherapy outcome, Long-term complication assessment A 49-year-old woman Discussion: presented with a biphasic SS tumor of the lower abdominal arising from the right Iliac blade. Our case has been treated as a local disease with a multidisciplinary therapeutic approach. As a result, our patient has been disease-free for two years and, during that time, has achieved an acceptable quality of life. We discuss the pertinent clinical and surgical ndings of this rare biphasic SS tumor in this report. Tumor staging and therapeutic management are usually clear for a localized disease, but the proper management at the metastatic stage can be unclear. According to the literature, the histologic presence of an SS tumor thrombus affects tumor staging, making it unclear whether the tumor stage corresponds to localized or metastatic disease. Treatment for localized SS typically consists of a combination of surgery, radiotherapy (RT) and, in some cases, chemotherapy. Adjuvant therapy in localized SS shows a response rate >65% for chemotherapy and >90% for RT. Nonetheless, the exact benet of administering systemic therapy once SS is nonlocalized is controversial. In a localized biphasic SS tumor surgical excision followed by radiation Conclusion: can cause miracle and also recurrence chances decrease. Early diagnosis and prompt treatment is the key for disease free survival.

2024-06-01·Diabetes & Metabolic Syndrome: Clinical Research & Reviews

First-trimester fasting plasma glucose as a predictor of subsequent gestational diabetes mellitus and adverse fetomaternal outcomes: A systematic review and meta-analysis

Review

作者: Kamrul-Hasan, A B M ; Bhattacharya, Saptarshi ; Kalra, Sanjay ; Boro, Hiya ; Bhat, Sowrabha ; Nagendra, Lakshmi ; Raj, John Michael ; Dutta, Deep ; Mondal, Sunetra

BACKGROUNDThe implication of intermediately elevated fasting plasma glucose (FPG) in the first trimester of pregnancy is uncertain.PURPOSEThe primary outcome of the meta-analysis was to analyze if intermediately elevated first-trimester FPG could predict development of GDM at 24-28 weeks. The secondary outcomes were to determine if the commonly used FPG cut-offs 5.1 mmol/L (92 mg/dL), 5.6 mmol/L (100 mg/dL), and 6.1 mmol/L (110 mg/dL) correlated with adverse pregnancy events.DATA SOURCESDatabases were searched for articles published from 2010 onwards for studies examining the relationship between first-trimester FPG and adverse fetomaternal outcomes.STUDY SELECTIONA total of sixteen studies involving 115,899 pregnancies satisfied the inclusion criteria.DATA EXTRACTION AND DATA SYNTHESISWomen who developed GDM had a significantly higher first-trimester FPG than those who did not [MD 0.29 mmoL/l (5 mg/dL); 95 % CI: 0.21-0.38; P < 0.00001]. First-trimester FPG ≥5.1 mmol/L (92 mg/dL) predicted the development of GDM at 24-28 weeks [RR 3.93 (95 % CI: 2.67-5.77); P < 0.0000], pre-eclampsia [RR 1.55 (95%CI:1.14-2.12); P = 0.006], gestational hypertension [RR1.47 (95%CI:1.20-1.79); P = 0.0001], large-for-gestational-age (LGA) [RR 1.32 (95%CI:1.13-1.54); P = 0.0004], and macrosomia [RR1.29 (95%CI:1.15-1.44); P < 0.001]. However, at the above threshold, the rates of preterm delivery, lower-segment cesarean section (LSCS), small-for gestational age (SGA), and neonatal hypoglycemia were not significantly higher. First-trimester FPG ≥5.6 mmol/L (100 mg/dL) correlated with occurrence of macrosomia [RR1.47 (95 % CI:1.22-1.79); P < 0.0001], LGA [RR 1.43 (95%CI:1.24-1.65); P < 0.00001], and preterm delivery [RR1.51 (95%CI:1.15-1.98); P = 0.003], but not SGA and LSCS.LIMITATIONSOnly one study reported outcomes at first-trimester FPG of 6.1 mmol/L (110 mg/dL), and hence was not analyzed.CONCLUSIONThe risk of development of GDM at 24-28 weeks increased linearly with higher first-trimester FPG. First trimester FPG cut-offs of 5.1 mmol/L (92 mg/dL) and 5.6 mmol/L (100 mg/dL) predicted several adverse pregnancy outcomes.

2024-05-02·Journal of Surgical Case Reports

Bouveret’s syndrome: a rare presentation of a common surgical enigma

作者: De, Utpal ; Chatterjee, Indranil

AbstractBouveret syndrome, an uncommon complication of cholelithiasis, typically manifests with symptoms of gastric outlet obstruction. Despite its rarity, Bouveret syndrome carries significant morbidity and mortality. This paper presents a case study and explores diagnostic approaches and management options for this challenging condition.

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