Background: Patients with coronavirus disease 2019 (COVID-19) are at increased risk of developing venous thromboembolism (VTE). Recent studies have shown that VTE is independently associated with increased mortality in hospitalized patients with COVID-19. Case: A 75 yr old male with past medical history of diabetes and chronic kidney disease presented with 3-day history of dyspnea and non-productive cough. COVID-19 screening test was pos. and chest CT angiog. showed acute saddle pulmonary embolism (PE) with right ventricular (RV) strain and bilateral ground glass opacities. Echocardiog. showed mildly reduced RV systolic function and TAPSE of 1.9 cm. Subsequently, systemic anticoagulation was initiated and patient was admitted to the ICU. Decision-making: Patient met the AHA criteria for sub-massive PE. Considering radiol. findings suggestive for COVID-19 pneumonia with high chance of clin. worsening given patient's age and comorbidities, decision was made to proceed with mech. thrombectomy (MT). Pulmonary angiogram showed complete occlusion of right main and left lower lobe pulmonary arteries with pulmonary artery pressure (PAP) of 35/10. Using the Inari FlowTriever System, large among of clots were extracted and post-MT PAP was 20/12. Conclusion: Rapid restoration of pulmonary circulation using MT in the setting of sub-massive PE and coexisting viral pneumonia could possibly decrease lung dead space and improve ventilation-perfusion mismatch.