更新于：2024-11-01

Scientific Center of Anti-Infective Drugs (SCAD)

2004

更新于：2024-11-01

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项与 Scientific Center of Anti-Infective Drugs (SCAD) 相关的临床试验

NCT05060705 / Not yet recruiting临床2期

Randomized Controlled Open Study of Safety and Preliminary Efficiency of the Drug "Efesovir" (Oral Solution) for Coronavirus Infection (COVID-19)

Study of the efficacy and safety of the new drug "Efesovir" in comparison with the drug "Remdesivir" in the treatment of patients hospitalized with COVID-19.
The hypothesis of clinical study is the clinical efficacy of new drug "Efesovir" is 10% to 30% higher than of "Remdesivir".

开始日期2025-12-01

申办/合作机构

Scientific Center of Anti-Infective Drugs (SCAD)

NCT04174937 / Completed临床1期

A Randomized, Placebo-controlled Study of the Tolerability, Safety and Pharmacokinetics of PA in Healthy Volunteers

This is a first-in-human (FIH) study to explore the safety, tolerability and pharmacokinetics of PA after oral ascending dose administration to healthy male volunteers.

开始日期2016-06-17

申办/合作机构

Scientific Center of Anti-Infective Drugs (SCAD)

NCT02607449 / Completed临床3期

Randomized, Placebo-controlled Study of Safety and Therapeutic Efficacy of the Drug FS-1 in the Oral Dosage Form in Drug-resistant Pulmonary Tuberculosis

Drug-resistant tuberculosis is becoming a major problem for the whole humanity, and development of new Anti-TB drugs is of great importance. Since Kazakhstan is a country with the high burden of tuberculosis, the Government of the Republic of Kazakhstan has founded initiative on the development of new Anti-TB drug to treat drug-resistant forms of this infectious disease. JSC "Scientific Center for Anti-infectious Drugs" has developed original drug FS-1 for the treatment of multidrug resistant tuberculosis (MDR-TB).

开始日期2013-12-01

申办/合作机构

Scientific Center of Anti-Infective Drugs (SCAD)

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100 项与 Scientific Center of Anti-Infective Drugs (SCAD) 相关的临床结果

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0 项与 Scientific Center of Anti-Infective Drugs (SCAD) 相关的专利（医药）

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项与 Scientific Center of Anti-Infective Drugs (SCAD) 相关的文献（医药）

2024-06-01·Non-coding RNA Research

Role of TRP channels in carcinogenesis and metastasis: Pathophysiology and regulation by non-coding RNAs

Review

作者: Tashenova, Gulnara ; Kapanova, Gulnara ; Duisekova, Samal ; Tulebayeva, Aigul ; Farooqi, Ammad Ahmad ; Akhenbekova, Aida ; Turgambayeva, Assiya

In 2021, David Julius and Ardem Patapoutian received Nobel Prize in Physiology or Medicine for their ground-breaking discoveries in the functional characterization of receptors for temperature and touch. Transient receptor potential (TRP) channels have captivated tremendous appreciation as promising drug targets over the past few years because of central involvement in different cancers. Based on the insights gleaned from decades of high-quality research, basic and clinical scientists have unveiled how Transient receptor potential channels regulated cancer onset and progression. Pioneering studies have sparked renewed interest and researchers have started to scratch the surface of mechanistic role of these channels in wide variety of cancers. In this review we have attempted to provide a summary of most recent updates and advancements made in the biology of these channels in context of cancers. We have partitioned this review into different subsections on the basis of emerging evidence about characteristically distinct role of TRPV (TRPV1, TRPV5), TRPM (TRPM3, TRPM7) and TRPC in cancers. Regulation of TRP channels by non-coding RNAs is also a very exciting area of research which will be helpful in developing a sharper understanding of the multi-step aspects of cancers.

2023-07-11·Medical oncology (Northwood, London, England)

TRAIL-mediated signaling in bladder cancer: realization of clinical efficacy of TRAIL-based therapeutics in medical oncology.

Review

作者: Venera, Rakhmetova ; Kapanova, Gulnara ; Akhmetova, Gulshara ; Kudabayev, Yerlan ; Tanbayeva, Gulnur ; Turgambayeva, Assiya ; Farooqi, Ammad Ahmad

Bladder cancer is a therapeutically challenging disease and wealth of knowledge has enabled researchers to develop a clear understanding of mechanisms which underlie carcinogenesis and metastasis. Excitingly, research over decades has unveiled wide-ranging mechanisms which serve as central engine in progression of bladder cancer. Loss of apoptosis, drug resistance, and pro-survival signaling are some of the highly studied cellular mechanisms. Therefore, restoration of apoptosis in resistant cancers is a valuable and attractive strategy. Discovery of TRAIL-mediated signaling cascade is an intriguing facet of molecular oncology. In this review, we have provided an overview of the translational and foundational advancements in dissecting the genomic and proteomic cartography of TRAIL signaling exclusively in the context of bladder cancer. We have also summarized how different natural products sensitized drug-resistant bladder cancer cells to TRAIL-mediated apoptosis. Interestingly, different death receptors that activate agonistic antibodies have been tested in various phases of clinical trials against different cancers. Certain clues of scientific evidence have provided encouraging results about efficacy of these agonistic antibodies (lexatumumab and mapatumumab) against bladder cancer cell lines. Therefore, multipronged approaches consisting of natural products, chemotherapeutics, and agonistic antibodies will realistically and mechanistically provide proof-of-concept for the translational potential of these combinatorial strategies in well-designed clinical trials.

2022-06-01·BMJ Open

Occupational burn-out, fatigue and stress in professional rescuers: a cross-sectional study in Kazakhstan

Article

作者: Krugovykh, Ilya ; Ongarbaeva, Damet ; Romanova, Zhanna ; Baigonova, Kaini ; Vinnikov, Denis ; Kapanova, Gulnara ; Ualiyeva, Aliya ; Tulekov, Zhangir ; Kalmakhanov, Sundetgali

ObjectivesTo find predictors of burn-out in a cohort of rescuers.DesignCross-sectional study.SettingRepublican Rescue Squad (N=105) and Republican Mudslide Rescue Service under the Ministry of Emergency Situations (N=480) in Almaty, Kazakhstan.ParticipantsIn total, we included 268 (80% men, median age 38 (IQR 22) years) rescuers from both organisations.Primary and secondary outcome measuresWe offered a questionnaire to rescuers, which included Maslach Burnout Inventory, quantifying emotional exhaustion (EX), cynicism (CY) and professional efficacy (PE) along with fatigue, stress and health-related quality of life (HRQL) tools.ResultsLower scores of HRQL (Physical Component Score (PCS) beta −0.04 (95% CI −0.06 to −0.02); Mental Component Score beta −0.03 (95% CI −0.05 to −0.01)), higher fatigue (Fatigue Severity Scale (FSS) score beta 0.03 (95% CI 0.03 to 0.04)) and stress (Perceived Stress Score-10 beta 0.04 (95% CI 0.02 to 0.06)) independently predicted greater EX. Lower PCS (beta −0.03 (95% CI −0.06 to −0.01)) and FSS (beta 0.02 (95% CI 0.01 to 0.03)) could predict more CY burn-out. In addition to stress, higher education (beta 0.86 (95% CI 0.40 to 1.32)) was positively associated with lower burn-out severity in PE domain.ConclusionsFatigue, stress and HRQL were associated with burn-out in rescuers. Addressing these predictors may help guide further interventions to reduce occupational burn-out.

100 项与 Scientific Center of Anti-Infective Drugs (SCAD) 相关的药物交易

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100 项与 Scientific Center of Anti-Infective Drugs (SCAD) 相关的转化医学

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