Effectiveness of platelet rich plasma in comparison with Triamcinolone Hexacetonide in improving pain and function in patients with de Quervains tenosynovitis: A Randomised controlled trial - Nil

开始日期2024-08-20

申办/合作机构

Regional Institute of Medical Sciences

CTRI/2024/07/071617 / Not yet recruitingN/AIIT

Prophylactic antibiotic versus no antibiotic in patients undergoing elective laparoscopic cholecystectomy: a randomized controlled trial - NIL

开始日期2024-08-12

申办/合作机构

Regional Institute of Medical Sciences

CTRI/2024/06/069383 / Not yet recruiting临床4期IIT

Comparative evaluation of half percent Ropivacaine with ropivacaine half percent and Dexmedetomidine in Ultrasound guided combined Femoral and Sciatic nerve block for lower limb surgeries. A Randomized clinical study - NIL

开始日期2024-07-01

申办/合作机构

Regional Institute of Medical Sciences

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0 项与 Regional Institute of Medical Sciences 相关的专利（医药）

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项与 Regional Institute of Medical Sciences 相关的文献（医药）

2024-10-01·Journal of Endodontics

Effect of the Time Interval of Functional Loading on the Periapical Healing of Endodontically Treated Mandibular Molar Teeth with Pulp Necrosis and Asymptomatic Apical Periodontitis: A Split-mouth Randomized Clinical Study

Article

作者: Logani, Ajay ; Kumar, Vijay ; Kangjam, Gunadhar Singh ; Chawla, Amrita ; Chirom, Babina ; Jain, Veena

INTRODUCTIONThis prospective study evaluated the effect of immediate functional loading (IFL) of a full-coverage prosthesis on the clinical and radiographic outcome of nonsurgical endodontic therapy (NSET) performed on mandibular molar teeth with pulp necrosis and asymptomatic apical periodontitis.METHODSIn 20 subjects, standardized 2-visit NSET was performed in bilateral mandibular first molar teeth (split-mouth model) with a diagnosis of pulp necrosis and asymptomatic apical periodontitis exhibiting a radiographic periapical index (PAI) score ≥3. In each subject, the nonvital bilateral mandibular first molar teeth were randomized to 1 of 2 groups: the IFL group or the functional loading after a time interval of 6 months group. Provisional full-coverage prostheses were provided within 7 days after the completion of endodontic therapy. The cases were followed up clinically and radiographically at 6 and 12 months. Radiographs were assessed for periapical healing based on PAI scores, which were dichotomized as healed (PAI score ≤2) or nonhealed (PAI score ≥3). The data were compared using chi-square and Fisher exact tests.RESULTSA recall rate of 100% was achieved at the end of 12 months. All teeth in the IFL group and the functional loading after a time interval of 6 months group were clinically asymptomatic. According to an intergroup comparison between the proportion of teeth healed and nonhealed (radiographic), there was a significant difference (P < .05).CONCLUSIONSIFL of a full-coverage prosthesis in endodontically treated mandibular molar teeth with pulp necrosis and asymptomatic apical periodontitis delayed periapical healing.

2024-09-28·Indian Journal of Pathology and Oncology

Study of microvascular density in carcinoma of breast

作者: Singh, Sarangthem Jogen ; Shah, Najeeya ; Debnath, Mautoshi ; Hussain, Shaik Mahammad Abzal ; Rainy, Rajkumari ; Babina, Sorokhaibam

: Angiogenesis, which is the creation of fresh vascular systems from existing blood vessels, is essential for cancer cells to obtain necessary nutrients, and oxygen, and eliminate waste. This process significantly contributes to the progression and spread of breast cancer. Evaluating microvascular density (MVD) is commonly used to measure angiogenesis within breast tumours.A cross-sectional study was conducted on 100 breast cancer cases for five years from July 2017 to June 2022 at the Department of Pathology RIMS, in collaboration with the Department of Surgery, RIMS. Tissue samples were processed, stained with Hematoxylin and Eosin, and then subjected to Immunohistochemical stain CD34. The analysis of the results was done using Spss version 21. The study revealed that higher microvessel counts were linked to older patients (above 50 years old), histological grades I to III, lymph node metastasis, and estrogen receptor-negative tumours. However, microvascular density was found to be unrelated to tumour size, histological grade, lymphovascular invasion, and morphological types.Hence we concluded that increased microvascular density (MVD) could be connected with increased aggressiveness of tumours, leading to a higher risk of metastasis and decreased survival rates. Various tumour and host factors have been identified as useful in predicting the likelihood of breast cancer recurrence and mortality post-primary surgery. Additionally, the quantitative assessment of microvessel density may not only have prognostic value but also aid in predicting responses to anti-angiogenic medications.

2024-09-28·Indian Journal of Pathology and Oncology

A study of histomorphological features of fallopian tube and immunohistochemical stains for p53 & ki67 of the fimbrial end of fallopian tube

作者: Rainy, Rajkumari ; Hussain, Shaik Mahammad Abzal ; Laishram, Rajesh Singh ; Nabina, Leishangthem ; Persy, Haobijam ; Mutum, Reeta

: Fallopian tube is the origin of ovarian cancer especially high grade serous carcinoma. Precursor lesion of ovarian cancers in the fallopian tube now recognized includes p53 signature, secretory cell outgrowth (SCOUT), tubal intraepithelial lesion in transition (TILT) and serous tubal intraepithelial lesion (STIC) through histomorphological features and by using immunohistochemical staining for p53 and ki67. This study emphasizes in detection of precursor lesion in fallopian tube in all resected fallopian tube submitted in the department during the study period. Ability to detect precursor lesion would have profound impact on preventive strategies of ovarian cancer and modalities of management of the disease in the initial stages that ultimately help in reducing the disease burden and increasing overall survival rate. : To determine the histomorphologiscl features of fallopian tube and to assess the evidence of precursor lesions in fallopian tube epithelium using immunohistochemistry stain p53 and ki67.: The study was carried out in the department of pathology in collaboration with the department of obstretics and gynecology, regional institute of medical sciences. Study was conducted for two years from September 2018 to August 2020. All the fallopian tubes specimen received during the study period were included in the study except those specimen with damaged, autolyesd, of post radiation therapy and post chemotherapy patients. A total of 120 specimen were collected. A total of 120 samples were included in the study. Mean age of the participants was 47 years with a minimum age of 24 years and maximum age of 72 years. 56. 7 % of the participants were in post menopausal age group. Out of the 120 cases only 12 cases (10 %) showed p53 signature and one case (0.8%) showed presence of STIC.: Only one case of STIC was detected in the fallopian tube where the ovary had High grade serous carcinoma. Few cases showed for p53 signature evident by using IHC p53 and ki67 which is more frequent in corresponding ovarian pathology than uterine pathology.

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