Delving into the Latest Updates on Chosun University College of Science & Technology with Synapse

概览

排名前五的药物类型	数量

小分子化药	3

排名前五的靶点	数量

15-PGDH(羟前列腺素脱氢酶)	3

关联

3

项与 Chosun University College of Science & Technology 相关的药物

15-PGDH inhibitors-compound3(Chosun University College of Science & Technology)

靶点

15-PGDH

作用机制

15-PGDH抑制剂

在研机构

Chosun University College of Science & Technology

原研机构

Chosun University College of Science & Technology

在研适应症-

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

15-PGDH inhibitors-compound4(Chosun University College of Science & Technology)

靶点

15-PGDH

作用机制

15-PGDH抑制剂

在研机构

Chosun University College of Science & Technology

原研机构

Chosun University College of Science & Technology

在研适应症-

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

15-PGDH inhibitors-compound2(Chosun University College of Science & Technology)

靶点

15-PGDH

作用机制

15-PGDH抑制剂

在研机构

Chosun University College of Science & Technology

原研机构

Chosun University College of Science & Technology

在研适应症-

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Chosun University College of Science & Technology 相关的临床结果

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0 项与 Chosun University College of Science & Technology 相关的专利（医药）

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104

项与 Chosun University College of Science & Technology 相关的文献（医药）

2024-08-01·Chemical Engineering Journal

Fully bioresorbable, all-polymer-based, 3D-printed scaffolds with prolonged radiopacity and enhanced durability

作者: Jeong, Yun-Jin ; Shanmugasundaram, Arunkumar ; Choi, Eunpyo ; Jo, Juyeong ; Choi, Byeongjun ; Lee, Dong-Weon ; Kang, Sumin ; Kim, Seokjae ; Kim, Hyungwoo

Effective tracking and monitoring of polymer-based biodegradable stents (BDSs) in vivo is crucial for their successful application in treating cardiovascular diseases.However, the lack of radiopacity in BDSs poses significant challenges in accurately monitoring the progress of the patient condition.To address this limitation, we propose the incorporation of a biodegradable contrast agent called PCL-TIB.PCL-TIB is synthesized by coupling 2,3,5-triiodobenzoic acid (TIB) with polycaprolactone diol (PCL-diol).The resulting PCL-TIB is then blended with polycaprolactone (PCL) to create a polymer matrix suitable for stent fabrication using additive manufacturing techniques.The mech. stability of the fabricated BDSs is evaluated through comprehensive analyses, demonstrating that the BDSs can withstand external forces and effectively retain their structural integrity.The cell viability of human umbilical vein endothelial cells HUVECs on the proposed BDSs exceeds 90% compared to the cell viability of the control group, signifying the excellent biocompatibility and cytotoxicity of the fabricated BDSs.Furthermore, in vivo X-ray visibility anal. of the fabricated BDSs, including those containing iohexol, reveals a decrease in radiopacity after 7 days, with no discernible X-ray radiopacity observed after 9 days.In contrast, BDSs incorporating the proposed biodegradable contrast agent maintain their X-ray radiopacity for up to 42 days, representing a significant achievement compared to previously reported radiopaque BDSs.Based on the results obtained, we believe that the fabricated BDSs exhibit excellent mech. stability, biocompatibility, and extended radiopacity, making them promising candidates for the treatment of various cardiovascular diseases.

2024-01-28·Journal of Applied Physics

On the importance of Akhiezer damping to thermal conductivity in silicon at elevated temperatures above 300 K

作者: Jin, Jae Sik

Recently, Chiloyan et al. [Appl. Phys. Lett. 116, 163102 (2020)] have reported that phonon transport could exceed bulk heat conduction if low-frequency phonons with long mean free path (MFP) remain in the nonthermal regime in silicon. To gain a better understanding of their findings, we investigated the effects of temperature-induced anharmonicity on both Landau–Rumer damping and Akhiezer damping, including polarization. To do this, we follow a rigorous procedure for calculating the Akhiezer model and use phonon kinetic theory based on the Boltzmann transport equation. Consequently, we find that in the Akhiezer regime, the longitudinal acoustic phonon modes (LA) are strongly suppressed by phonon anharmonicity compared to the transverse acoustic phonon modes. Therefore, the low-frequency phonons with a long MFP of LA can help to exceed bulk heat conduction if they remain in the regime of nonthermal phonon transport where there are no appreciable scatterings with other phonons. It is also shown that Akhiezer damping eliminates thermal conductivity by 16.8% at 500 K, which is higher than the observed reduction (12.6%) at 300 K in silicon, uncovering a novel regime where the Akhiezer damping, previously deemed insignificant in the thermal conduction of bulk silicon, becomes crucial.

2023-10-01·Ecotoxicology and Environmental Safety

Aquatic toxicity and fate of styrene oligomers in the environment

Article

作者: Kwon, Bum Gun

Styrene oligomers (SOs) are ubiquitous contaminants that appear in the environment, sometimes to significant extent (see section 3.1). Despite the ongoing international debate on the human health risks posed by SOs, to the best of my knowledge, there are no studies on the aquatic toxicity and environmental fates (biodegradation and atmospheric degradation) of SOs in the environment. This study is to predict the aquatic toxicity and environmental fate of SOs by using the US EPA EPI suite program as an in-silico method. For better understanding, the risks and fates of SOs are compared with those of the well-known bisphenol A (BPA) and styrene monomer (SM or styrene). As a result of this study, SOs are predicted to be relatively more toxic than BPA and SM to aquatic and terrestrial organisms in the freshwater, marine, and terrestrial environments. In particular, the biodegradability of SOs is predicted to be relatively very slow in the environment, and most SOs are more likely to be effectively decomposed by hydroxyl radicals than by ozone in the atmosphere. As a result, this study can contribute to motivating understanding of the aquatic toxicity and fate of ubiquitous SOs in the environment.

100 项与 Chosun University College of Science & Technology 相关的药物交易

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100 项与 Chosun University College of Science & Technology 相关的转化医学

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临床前

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当前项目

药物(靶点)	适应症	全球最高研发状态

15-PGDH inhibitors-compound3(Chosun University College of Science & Technology) ( 15-PGDH )	-	临床前
15-PGDH inhibitors-compound2(Chosun University College of Science & Technology) ( 15-PGDH )	-	临床前
15-PGDH inhibitors-compound4(Chosun University College of Science & Technology) ( 15-PGDH )	-	临床前