Delving into the Latest Updates on 广西民族大学 with Synapse

概览

疾病领域	数量

肿瘤	1
内分泌与代谢疾病	1

排名前五的药物类型	数量

小分子化药	2

排名前五的靶点	数量

MIR7-3HG	1

关联

2

项与广西民族大学相关的药物

CN116178329

专利挖掘

靶点-

作用机制-

在研机构

广西民族大学

原研机构

广西民族大学

在研适应症

内分泌与代谢疾病

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

CN116332940

专利挖掘

靶点

MIR7-3HG

作用机制-

在研机构

广西民族大学

原研机构

广西民族大学

在研适应症

肿瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

100 项与广西民族大学相关的临床结果

登录后查看更多信息

0 项与广西民族大学相关的专利（医药）

登录后查看更多信息

5,620

项与广西民族大学相关的文献（医药）

2025-12-31·International Journal of Systems Science: Operations & Logistics

Sustainable multi-objective location-routing problem with time windows: a case study in China

作者: Guo, Jing ; Su, Dandan ; Li, Hui

2025-08-01·Talanta

CRISPR/Cas12a trans-cleavage cascading dual-template exponential amplification reaction for electrochemiluminescent detection of 17β-estradiol in milk

Article

作者: Du, Hang ; Yan, Jun ; Zhou, Yu-Yi ; Feng, De-Fen ; Wu, Jia-Wen ; Huang, Ke-Jing ; Tan, Xue-Cai ; Wu, Ye-Yu

17β-Estradiol (E2) is a common environmental estrogen that can interfere with the endocrine systems of humans and animals, and poses a carcinogenic risk even at picomolar concentrations. In this study, a functionalized Ru(bpy)₃²⁺-embedded metal-organic framework (ZnRuMOF) is synthesized, in which Ru(bpy)₃²⁺ served as an electrochemiluminescence (ECL) indicator and the porous structure of ZnRuMOF acts as a nanoreactor to enhance the ECL signal. Based on this, we developed an E2 detection method combining a highly specific CRISPR-Cas12a system and dual-template exponential amplification. This method utilizes the trans-cleavage activity of CRISPR-Cas12a to control a light switch, achieving precise and ultra-sensitive detection of E2. The sensing platform demonstrates excellent performance in detecting E2 concentrations ranging from 1 fg mL^-1 to 150 ng mL^-1, with a detection limit of 0.27 fg mL^-1 (S/N = 3). This study provides a reliable approach for diagnosing and treating diseases related to E2, aiming to protect environmental quality and human health.

2025-08-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Corrigendum to “A polarity-sensitive fluorescent probe for visualizing lipid droplets in ferroptosis, cuproptosis, and autophagy” [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 332 (2025) 125854]