Guangxi Minzu University

Survivin, a multifunctional regulator of mitosis and apoptosis, plays a central role in cancer progression and therapy resistance, making it an attractive target for anticancer drug development. In this study, a series of 4,6-diphenyl-3-cyanopyridine derivatives were designed and synthesized as potential survivin inhibitors through an integrated strategy combining 3D-QSAR modeling, molecular docking, molecular dynamics simulations, and biological evaluation. The CoMFA and CoMSIA models established reliable structure-activity relationships and provided contour-map-based guidance for rational molecular optimization. Newly designed derivatives displayed enhanced antiproliferative effects against melanoma cells, and computational analyses revealed that the most promising compound showed stable and preferential binding within the BIR domain of survivin, particularly in its dimeric form. These findings demonstrate the effectiveness of contour-guided optimization in discovering novel survivin-targeting scaffolds and highlight 4,6-diphenyl-3-cyanopyridine derivatives as promising leads for further anticancer drug development. Future studies will focus on improving selectivity, clarifying the inhibition mechanism at the molecular level, and evaluating in vivo efficacy.

Covalent organic frameworks (COFs) demonstrate great potential as photocatalysts for the remediation of organic pollutants; however, their efficiency is often limited by the factor of rapid electron-hole recombination. In response to this challenge, we anchor ultrasmall (∼2.5 nm) bimetallic Au-Ag nanoclusters within the porous architecture of a nitrogen-rich COFs scaffold. The nitrogenated frameworks not only provide a high surface area and abundant active sites but also facilitate electron transfer. Meanwhile, the ultrafine Au-Ag nanoclusters exhibit strong plasmonic coupling, serving as dual light-harvesting units and electron transfer mediators. This synergistic configuration enhances carrier separation, enabling plasmon-exciton co-driven catalysis. The optimized COF-Au-Ag achieves simultaneous degradation of nizatidine (NZTD) and production of hydrogen peroxide (H₂O₂) via a unified photocatalytic mechanism centered on efficient charge separation and directional migration. This photocatalyst illustrates excellent recyclability in five consecutive cycles of use, offering a novel approach for designing multifunctional COF-based photocatalytic systems.

Autism parenting in China is shaped by a distinct sociocultural landscape where evolving awareness intersects with entrenched Confucian familism. While the parenting experience is multifaceted, this study conducts a targeted analysis of narratives of burden and suffering as they appear in autism parenting discourse on Xiaohongshu, a popular Chinese social media platform. Through a qualitative, metaphor-led discourse analysis of 55 posts, we identify and analyze three key themes within the register of hardships: (1) Battlefront, where war and economic metaphors convey profound distrust of a privatized intervention industry perceived as profit-oriented; (2) Care Crisis, where spatial and gendered metaphors articulate maternal despair, financial ruin, and self-erasure; and (3) Familial Disruption, where dehumanizing and Buddhist metaphors frame autism as a generational catastrophe. Metaphors like "a thorn in my heart" and "three-generation butterfly effect" are not merely linguistic flourishes; they function as culturally resonant narratives of parental distress and resistance. Furthermore, the analysis reveals a critical elision in parental discourse, where metaphors of the child as a burden coexist with social critique, illustrating how the child's condition becomes the locus how the child's condition becomes the locus for experiencing structural constraints. By centering these expressions of systemic and gendered suffering, our findings highlight an urgent need for multi-tiered reforms, including expanded state support and culturally tailored anti-stigma initiatives, to address the profound burdens faced by these families.