The Role of mTOR (Mammalian Target of Rapamycin) Signaling Pathway in the Antidepressive Effect of Ketamine in Patients with Depressive Disorder. - D-KET-mTOR

开始日期2013-04-29

申办/合作机构

Prague Psychiatric Center

NCT01885923 / Unknown statusN/AIIT

Prospective, Randomized, Open, Controlled Study With Information and Telecommunication Technology-aided Relapse Prevention Program in Schizophrenia.

THE AIM OF THE PROJECT The main aim lies in the prevention of frequent relapses typical for schizophrenia and schizoaffective disorder by means of simple, highly cost-effective information technology-aided approach RESEARCH HYPOTHESIS A the end of 18 months study duration, patients in the active group enrolled in ITAREPS will demonstrate statistically significantly reduced risk of hospitalization, decreased number of hospitalization days and reduced direct inpatient costs in comparison to control group not using the program.

开始日期2012-08-01

申办/合作机构

Prague Psychiatric Center

EUCTR2009-010625-39-CZ / Not yet recruitingN/AIIT

QEEG cordance and EEG connectivity changes after administration of subanesthetic ketamine doses in depressive disorder patients - AD-KET-QEEG

开始日期2010-04-21

申办/合作机构

Prague Psychiatric Center

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2023-12-01·Psychological Medicine

Cultural contributions to adults' self-rated mental health problems and strengths: 7 culture clusters, 28 societies, 16 906 adults

Article

作者: Samaniego, Virginia C ; Ivanova, Masha Y ; Tong, Guangyu ; Vazquez, Natalia ; Sakarya, Direnc ; Caldas, J Carlos ; Ndetei, David M ; Wolanczyk, Tomasz ; Copeland, William E ; Markovic, Jasminka ; Lecannelier, Felipe ; Riad, Geylan ; Shahini, Mimoza ; da Rocha, Marina M ; Leung, Patrick ; Chen, Yi-Chuen ; Sokoli, Elvisa ; Talcott, Joel B ; Liu, Jianghong ; Malykh, Sergey ; Au, Alma ; Mahr, Safia ; Simulioniene, Roma ; Silvares, Edwiges ; Oh, Kyung Ja ; Dobrean, Anca ; Achenbach, Thomas M ; Funabiki, Yasuko ; Csemy, Ladislav ; Zasepa, Ewa ; Ezpeleta, Lourdes ; Turner, Lori V ; Sebre, Sandra ; Harder, Valerie S ; Ahmeti-Pronaj, Adelina ; Petot, Jean-Michel ; Leiner de la Cabada, Marie ; Bellina, Monica

AbstractBackgroundIt is unknown how much variation in adult mental health problems is associated with differences between societal/cultural groups, over and above differences between individuals.MethodsTo test these relative contributions, a consortium of indigenous researchers collected Adult Self-Report (ASR) ratings from 16 906 18- to 59-year-olds in 28 societies that represented seven culture clusters identified in the Global Leadership and Organizational Behavioral Effectiveness study (e.g. Confucian, Anglo). The ASR is scored on 17 problem scales, plus a personal strengths scale. Hierarchical linear modeling estimated variance accounted for by individual differences (including measurement error), society, and culture cluster. Multi-level analyses of covariance tested age and gender effects.ResultsAcross the 17 problem scales, the variance accounted for by individual differences ranged from 80.3% for DSM-oriented anxiety problems to 95.2% for DSM-oriented avoidant personality (mean = 90.7%); by society: 3.2% for DSM-oriented somatic problems to 8.0% for DSM-oriented anxiety problems (mean = 6.3%); and by culture cluster: 0.0% for DSM-oriented avoidant personality to 11.6% for DSM-oriented anxiety problems (mean = 3.0%). For strengths, individual differences accounted for 80.8% of variance, societal differences 10.5%, and cultural differences 8.7%. Age and gender had very small effects.ConclusionsOverall, adults' self-ratings of mental health problems and strengths were associated much more with individual differences than societal/cultural differences, although this varied across scales. These findings support cross-cultural use of standardized measures to assess mental health problems, but urge caution in assessment of personal strengths.

2022-05-01·International Journal of Clinical and Health Psychology1区 · 心理学

Emotional Dysregulation in Adults from 10 World Societies: An Epidemiological Latent Class Analysis of the Adult-Self-Report

1区 · 心理学

ArticleOA

作者: Nobile, Maria ; Csemy, Ladislav ; Frigerio, Alessandra ; Rescorla, Leslie ; Decoster, Jeroen ; Ivanova, Masha Y ; Rosi, Eleonora ; Mauri, Maddalena ; Ndetei, David M ; Molteni, Massimo ; Fontaine, Johnny R J ; Sokoli, Elvisa ; Funabiki, Yasuko ; Oh, Kyung Ja ; da Rocha, Marina M ; Grazioli, Silvia ; Šimulioniene, Roma ; Achenbach, Thomas M ; Bianchi, Valentina

Background/ObjectiveEmotional dysregulation (ED) is a dimensional psychological domain, previously operationalized by instruments of the Achenbach System of Empirically Based Assessment (ASEBA) for children and adolescents; however, its cross-cultural and bottom-up characteristics among adult populations are still unknown.MethodWe examined scores obtained on the Adult Self-Report (ASR) by 9,238 18- to 59-year-olds from 10 societies that differed in social, economic, geographic, and other characteristics. A Latent Class Analysis was performed on the data from each society.ResultsIn each society, a dysregulated class (DYS) was identified, which was characterized by elevated scores on most ASR syndromes. The mean prevalence of DYS was 9.2% (6.1-12.7%). The best models ranged from three to five latent classes in the different societies.ConclusionsAlthough the number of identified classes and the prevalence of ED varied across societies, a DYS class was found in each society, suggesting the need to adopt a dimensional view of psychopathology and a cross cultural perspective also in adult populations.

2016-09-01·Neuro endocrinology letters

Long term pharmacotherapy by methylfenidate or atomoxetine DAT 1 10/10 ADHD children in correlation with results of the imaging methods.

Article

作者: Kohoutova, Milada ; Paclt, Ivo ; Csemy, Ladislav ; Dezortova, Monika ; Pribilova, Nikol ; Hajek, Milan ; Kollarova, Patricie

OBJECTIVESADHD is one of the most significant diagnostic units in child and adolescent psychiatry. The occurrence in children is 5-6% and 50-80% continued to adult age. The presence of individual genes (polymorphism) on particular symptoms and processes in ADHD are not known. It is estimated that ADHD symptoms are up to 80% to genetic. The higher density of resultant DAT 1 protein was observed in ADHD patients in comparison with controls. The question was if DAT 1 10/10 predicted bad prognoses in long term therapy.METHODSWe compared 30 ADHD DAT 1 10/10 adolescents treated for 5-6 years. Patients with 30 control adolescents. They were the same age of probands and controls. All these subjects were examined by child psychiatry scales (Conners, Achenbach…). Biological changes were tested by MRI specific CNS volumometry.RESULTSWe didn't confirm bad prognoses in long term therapy with methylphenidate or atomoxetine in ADHD children DAT 1 10/10 in long term therapy. In MRI specific CNS volumometry were not identify any differences in controls and ADHD probands. Gray matter thickness was significantly higher in prefrontal and occipital areas in patients compared to control in prefrontal and occipital areas with cluster-wise p-value<0.05. By this method were not identify any cerebrum damage in long term therapy by methylphenidate and atomoxetine.

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