Does Flow Trigger Sensitivity Adjustment Is Translational Mechanisms For Therapeutically Alternatives In Ventilator-Induced Diaphragm Dysfunction Critically Ill Patients?

The study is a prospective experimental study on adult patients admitted to the Critical Care Department in Qasr Al-Ainy. This study is conducted prospectively to assess the efficiency of trigger sensitivity adjustment on patients with ventilator-induced diaphragmatic dysfunction (VIDD).

开始日期2024-08-01

申办/合作机构

South Valley University

NCT06546059 / Not yet recruitingN/AIIT

Gasdermin D Expression in Generalized Vitiligo Patients After Narrow-band Ultraviolet B Therapy

The aim of this study is to:
1. Evaluate the role of tissue Gasdermin D expression using immunehistochemstry techniques in patients with generalized vitiligo and compare it with healthy controls.
2. Evaluation expression of tissue Gasdermin D using immunehistochemstry techniques in patients with generalized vitiligo after narrow band ultraviolet B therapy.
3. Determine whether there is a relationship between Gasdermin D levels and disease duration and involved body surface area (VISA) in vitiligo patients.

开始日期2024-08-01

申办/合作机构

South Valley University

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2024-11-01·Journal of Molecular Structure

Synthesis, characterization, computer-aided docking studies, and anti-fungal activity of two-armed quinazolin-2,4‑dione derivatives

作者: Omar, Mohamed ; Rashdan, Huda R. M. ; Taha, Mohamed M. ; Abobakr, Ahmed M. ; Abdelmonsef, Aboubakr H.

A new series of two-armed quinazolin-2,4-diones incorporating N- heterocyclic moieties such as β-lactam, piperidine and/or morpholine, 2-thioxo imidazolidin-4-one and 2-iminothiazolidin-4-one 2-7 were designed and synthesized as attractive anti-fungal scaffolds.The structural elucidation of newly compounds was performed by means of FT-IR, ¹H NMR, ¹³C NMR and MS techniques.Subsequently, the newly synthesized compounds were screened for their antifungal activity against Candida albicans via measuring the inhibition zone diameter around the fungal growth.The results obtained revealed varied response activity toward the tested fungal pathogen.Three most potent compounds 1, 3, and 4 exhibited noted inhibitory effects.Since, there was found superiority of the compound 1 in terms of inhibition zone diameter (mm) about the standard drug (i.e. Amphotericin B).Addnl., the MIC value was assessed for the potent compounds using different concentrations (5-400 μg/mL).A significant MIC value (20 μg/mL) was recorded for compound 1.Moreover, the mol. docking simulation was performed against sterol 14-alpha demethylase.In particular, compound 1 exhibited the best binding profile among the synthesized compounds (- 13.6 kcal/mol), followed by compounds 3 (-12.7 kcal/mol) and 4 (-11.9 kcal/mol).The structure activity relationship revealed the importance of electron withdrawing groups (chlorine atoms) on biol. activity of compoundsFurther, the eight compounds exhibited good ADMET profile and satisfied the Lipinski rule of drug likeness.

2024-11-01·Microchemical Journal

Carbon Nano-Dots based potentiometric sensor for the assay of the antiviral agent; Valacyclovir: In-Depth DFT Calculations, application to the pharmaceutical formulation and greenness assessment

作者: Naguib, Ibrahim A. ; Abdel Hakiem, Ahmed Faried ; Mahfouz, Refaat M. ; Kamal, Ahmed Mohsen ; Mohammed, Ahmed A. K. ; Mohammed, Ahmed A.K. ; Mahfouz, Refaat M ; Aboraia, Ahmed Safwat ; Draz, Mohammed E.

Valacyclovir (VAL), as a prodrug to acyclovir antiviral agent, has recently held a lot of interest for its efficacy boosting owing to the significant improvement in bioavailability.This makes it a successful candidate in the management of herpes simplex strains as well as CORONA viruses.In this work a carbon nano dot-modified glassy carbon electrode (GCE) has been optimized as potentiometric sensor for the assay of VAL through a systematic approach.A mixture components of polyvinyl chloride (PVC) membrane have been selected and fine-tuned for optimum sensitivity and selectivity.The best results have been obtained by drop casting a blend in % weight/weight of PVC; 30.85, tricrasyl phosphate (TCP) as plasticizer; 64.32, phosphotungstic acid (PT) as cation exchanger; 1.61 and phosphorus - nitrogen-doped carbon nano-dots (PNCDs); 3.22 over the GCE.The d. function theory (DFT) calculations have been applied to the optimized structures of VAL and the CDs and have proven high binding affinity of 46 kcal/mol dominated by π-π stacking and hydrogen bonding.The developed sensor has exhibited a swift response time of six seconds at a 5.00 pH value.The ICH guidelines have been applied to validate the optimized parameters.A good linearity range has been obtained from 1.18 x 10^-3 down to 1.07 x 10^-6 M for a correlation coefficient 0.9996 with a Nernstian slope of 33.16 mV/decade.The greenness has been assessed using the AGREE approach, giving a score of 0.8, which has indicated the environmental friendliness.An average % recovery of almost 99.00 % was obtained by application to the tablet formulations and furtherly it has been monitored by the standard addition method, giving recoveries varied from 98.00 and up to 102.00 % for relative standard deviation values (%RSD) less than 1.50 %, evidencing efficiency for application in the quality control laboratories

2024-10-02·Food Reviews International

Unveiling the Mechanisms of the Development of Blueberries-Based Functional Foods: An Updated and Comprehensive Review