IKBKB Gene Polymorphism (Single Nucleotide Polymorphism) (SNP) in Psoriatic and Psoriatic Arthritis Patients and Its Relation With Response to Systemic Biologic Therapy

Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. It impairs patients' quality of life enormously.
Psoriasis refers to a persistent inflammatory illness of the skin and joints. It also impacts roughly 2%-3% of the inhabitants of the universe

开始日期2024-12-01

申办/合作机构

South Valley University

NCT06762990

/ Enrolling by invitationN/AIIT

Evaluating Changes of Spino-pelvic Radiological Parameters During Muslim Prayer Positions: a Cross-sectional Study

This observational study aims to investigate the spinopelvic relationship parameters change during the five main positions during Muslim prayers. The main questions the study is going to answer: What are the changes of the spinopelvic parameters during different Muslim prayer positions?

开始日期2024-11-27

申办/合作机构

South Valley University

NCT06681701

/ Not yet recruitingN/AIIT

Effectiveness of Combined Manual Therapy and Pulmonary Exercises on Ventilatory Function in Patients With Restrictive Lung Diseases: A Randomized Control Trial

This research investigates the effect of selective manual therapy techniques on chest expansion, pulmonary function (FVC, FEV1, and FEV1/FVC ratio), and functional capacity, in restrictive lung disease patients. The research hypothesis will be that no statistically significant difference would be found between manual therapy combined to conventional treatment and conventional treatment alone in restrictive lung disease patients.

开始日期2024-11-15

申办/合作机构

South Valley University

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项与 South Valley University 相关的文献（医药）

2025-03-01·Journal of Molecular Structure

Synthesis, spectroscopic characterization, antibacterial activity, and effective removal of Bengal rose dye of some transition metal complexes

作者: Fouad, Omar A. ; Hassan, Ahmed A. S. ; Mohamed, Gehad G. ; El-Nahas, Safaa ; Salman, Hassan M.

A series of transition metal complexes comprising Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) have been synthesized utilizing the Schiff base ligand (L) derived from 1,3-diaminopropane and 2-hydroxy-1-naphtaldhyde.The synthesized metal complexes were characterized using elemental analyses, spectroscopic techniques (¹HNMR, UV-visible, FT-IR), magnetic measurements, molar conductivity tests, and thermal anal. studies (TG and DTG).The complexes were formed at a stoichiometric ratio of 1:1 between the metal and L, as determined by the elemental anal. data.The IR spectra confirmed that the ligand displayed bidentate characteristics.The determination of the octahedral geometry of the complexes was based on magnetic moment measurements and electronic spectra.An anal. was conducted on the thermal properties of these chelates, which showed that the complexes with water mols. undergo a process of water removal in the beginning, followed by the breakdown of the anions and ligand mols.The complexes of Fe(III), Mn(II), Ni(II), and Cu(II) displayed a nanostructure, as confirmed by studies made using the scanning electron microscope (SEM) and at. force microscope (AFM).In addition, AFM examination verified that the Fe(III), Mn(II), Ni(II), and Cu(II) complexes had a uniform surface structure consisting of almost spherical grains.The BET anal. and contact angle measurement confirmed the significant surface area, mesoporous structure, and hydrophobic properties of the generated complexes.The biol. activity data showed that the metal complexes displayed higher antibacterial activity compared to the original Schiff base ligand against one or more species.Mol. docking was used to predict the binding efficiency between a Schiff base ligand (L) and metal complexes with the receptors of crystal structures associated with cell cancer (7DAE), COVID-19 (6W41), Candida albicans (5JPE), Neisseria gonorrhoeae (5WAM and 5WAQ), E. coli (1NEK and 4N74), Pseudomonas aeruginosa (3ix3), Bacillus subtilis (3AHU), Staphylococcus aureus (1GHP, 1JIJ, and 1JIL), and Staphylococcus mutans (2ZIC and 3AIC).The nanocomplexes of Fe(III), Cu(II), Mn(II), and Ni(II) were used as adsorbents to remove b∼engal rose dye, resulting in a high removal percentage.

2025-01-07·Current Organic Synthesis

WITHDRAWN: In vivo and In vitro Evaluation of Some New Pyrazole Derivatives in Comparison with Celecoxib

作者: Hassan, Entesar A. ; El-kerdawy, Mohammed M. ; Abozied, Asmaa M. ; Zayed, Salem E.

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn from the journal Current Organic Synthesis. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php BENTHAM SCIENCE DISCLAIMER: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultane-ously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submit-ting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

2025-01-01·Physica Scripta

A DFT/TD-DFT study on the π-spacer effect of coumarin 102-Based dyes for dye-sensitized solar cells applications

作者: Ebied, Mostafa Saad

AbstractDeveloping new organic dyes with optimized electronic structures and superior light-harvesting capabilities is crucial for enhancing the efficiency of dye-sensitized solar cells (DSSCs). In the current study, four novel D-π-A organic dye molecules (MC1-MC4), with various π spacers, were designed based on Coumarin-102 dye to investigate their prospective uses in dye-sensitized solar cells (DSSCs). Therefore, DFT and TD-DFT calculations were utilized to explore the electronic structure and photophysical and photovoltaic properties of the designed dyes. Specifically, the optimized structures, electronic parameters, Frontier molecular orbitals (FMOs), Natural Bond Orbital (NBO) analysis, Density of States (DOS) analysis, and Global Reactivity Parameters (GRPs) were evaluated. The calculated values of the energy difference between HOMO and LUMO ranged from 2.63 to 2.97 eV, with the MC2 dye having the smallest band gap (2.63 eV). Furthermore, the influence of π spacers on the performance of DSSCs was studied by calculating the Non-Linear optical (NLO) characteristics, UV–vis spectra, and other important parameters determining the photovoltaic performance of DSSCs. The results show that MC2 exhibits the highest value of light-harvesting efficiency (0.96) and a more negative ΔGinject (−1.323 eV), indicating that MC2 would demonstrate a higher JSC and could theoretically be a better sensitizer of DSSC device.

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