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143

项与 South Valley University 相关的临床试验

NCT06492603

/ Not yet recruitingN/AIIT

Examination of Linea Alba Biomechanical and Viscoelastic Characteristics in Patients Diagnosed with Diastasis Recti Using Ultrasound

Diastasis recti is an increased distance between the rectus abdominis muscles at the midline caused by weakness in the anterior abdominal wall.

开始日期2025-05-20

申办/合作机构

South Valley University

NCT06835413

/ Not yet recruitingN/AIIT

Monitoring Combined Effect of Balance and Strengthening Exercises on Static and Dynamic Balance in Elderly Populations

The purpose of training is to evoke improvements in reactive balance, then the training program may be associated with all postural control systems, including the musculoskeletal system, the cognitive system, as well as the somatosensory feedback system, while challenging the body in different environmental situations and unexpected perturbations

开始日期2025-05-15

申办/合作机构

South Valley University

NCT06681701

/ Not yet recruitingN/AIIT

Effectiveness of Combined Manual Therapy and Pulmonary Exercises on Ventilatory Function in Patients with Restrictive Lung Diseases: a Randomized Control Trial

This research investigates the effect of selective manual therapy techniques on chest expansion, pulmonary function (FVC, FEV1, and FEV1/FVC ratio), and functional capacity, in restrictive lung disease patients. The research hypothesis will be that no statistically significant difference would be found between manual therapy combined to conventional treatment and conventional treatment alone in restrictive lung disease patients.

开始日期2025-03-15

申办/合作机构

South Valley University

100 项与 South Valley University 相关的临床结果

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0 项与 South Valley University 相关的专利（医药）

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6,490

项与 South Valley University 相关的文献（医药）

2025-12-31·NRIAG Journal of Astronomy and Geophysics

Investigation of double geomagnetic storms on 3 and 4 February 2022 using machine learning approach

作者: El-Hamaly, Ibrahim ; Hegy, Mostafa ; Nahool, T.A. ; Helaly, Ahmad ; Ghamry, Essam ; Fathy, Adel ; Abd El Nabi, Sami

2025-05-04·Baylor University Medical Center Proceedings

Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials

作者: Abuklish, Duha Milad ; Abdelsalam, Fares ; Belal, Mohamed Mohamed ; Bashir, Mohamed Nabih ; Tanas, Yousef ; Abdrabou Abouelmagd, Alaa ; Marey, Ahmed ; Abdelrehim, Amro Mamdouh

2025-05-01·Results in Chemistry

Unveiling the antimicrobial activity of some new Quinazolindione-anchored Pyrazole, Chromene and/or Furo[2,3-b]indole hybrids through Acylthiourea conjugate: Synthesis, molecular docking, Semiempirical calculations and ADMET prediction

作者: Mosallam, Ahmed M. ; Khodairy, Ahmed ; Ibrahim, Amal O. A. ; Rashdan, Huda R. M. ; Abdelmonsef, Aboubakr H. ; Alsoghier, Hesham M.

Due to the current need to identify novel and potent drug candidates for treating diseases caused by bacterial and fungal strains.Herein, in this article, our goal is to identify possible potential antimicrobial candidates.The present work includes design and prepare three new series of quinazolindione-based acylthiourea incorporating five and/or six membered rings such as pyrazole, furo[2,3-b]indole and chromene moieties 3-8, in an effort to investigate their potential antimicrobial properties.The starting compound 2 has been synthesized by reaction of benzoyl chloride derivative 1 with cyanoacetic acid hydrazide and ammonium thiocyanate via one pot three components reaction.Addnl., Knovenagel condensation of 2 with various heteroaromatic/ aromatic aldehydes and/or aromatic ketone yielded quinazolin-2,4-diones-anchored acylthiourea conjugate with N/O heterocycles 3-8 in good yields ranging from 60 to 75 %.Their chem. structures were authenticated utilizing multispectroscopic techniques such as IR, ¹H-& ¹³C NMR and MS along with the elemental analyses.Further, the antimicrobial potential of the products was in vitro assessed against different bacterial and fungal pathogenic strains.The results revealed that compounds 3b and 3c demonstrated the strongest inhibitory effects against the tested microbial strains at low concentrationsAlongside, virtual screening based on mol. docking studies was further performed on the newly synthesized quinazolin-2,4-diones towards the enzymes Staphylococcus aureus tyrosyl-tRNA synthetase (TyrRS), Pseudomonas aeruginosa lipase enzyme and Candida albicans dihydrofolate reductase (C. albicans DHFR), using ciprofloxacin and nystatin as antibacterial and antifungal standard drugs, resp.Further, structure activity relationship (SAR) for 3b and 3c was rationalized by investigating the effect of substituents on inhibitory potential.A semiempirical modeling was performed for geometric optimization of the best docked mols.Our work recommends that compound 3b and 3c could be promising leads for development of potent antimicrobial agents.

100 项与 South Valley University 相关的药物交易

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100 项与 South Valley University 相关的转化医学

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