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项与 Toyo Hakka Kogyo Co., Ltd. 相关的药物

ATX-70

靶点-

作用机制

光敏剂

在研机构-

原研机构

Toyo Hakka Kogyo Co., Ltd.

在研适应症-

非在研适应症

肿瘤

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

STABX-909

靶点-

作用机制-

在研机构-

原研机构

Toyo Hakka Kogyo Co., Ltd.

在研适应症-

非在研适应症

胶质瘤

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Toyo Hakka Kogyo Co., Ltd. 相关的临床结果

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0 项与 Toyo Hakka Kogyo Co., Ltd. 相关的专利（医药）

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2

项与 Toyo Hakka Kogyo Co., Ltd. 相关的文献（医药）

1991-01-01·YAKUGAKU ZASSHI4区 · 医学

Quantitative Analysis of (-)-Epigallocatechin Gallate in Tea Leaves by High-Performance Liquid Chromatography

4区 · 医学

Article

作者: Sakata, Isao ; Okuda, Takuo ; Ikeuchi, Masako ; Maruyama, Izumi

The quantitative analysis of (-)-epigallocatechin gallate (EGCG) in tea (Camellia sinensis L.) was performed by high-performance liquid chromatography (HPLC) with a C-18 reversed-phase column. EGCG was then eluted within 20 min by using methanol-water-acetic acid (20:75:5 (v/v/v)) as an eluent. As an internal standard, tryptophan was used. The content of EGCG in five kinds of green tea (sencha, gyokuro, bancha, matsucha and oolong tea) and in a cup of those was determined by both the extraction method with 50% (v/v) methanol and the infusion method with water. The largest amount of EGCG was obtained from matsucha by the extraction method, or from sencha by the infusion method. Furthermore, EGCG contents in various parts of the tea plant were examined. The first leaf had the highest concentration of EGCG, and the concentration of EGCG decreased with the aging of the leaf.

1990-01-01·YAKUGAKU ZASSHI4区 · 医学

Studies on Porphyrin Related Compounds and Tumor Tissue Affinities. I. Synthesis of a Carrier for Tumor Imaging Agent, Bifunctional Chelating Agent Coupled Porphyrin (ATN-2)

4区 · 医学

Article

作者: Takata, Hiroyuki ; Sakata, Isao ; Yamauchi, Hirohiko ; Hirata, Naomi ; Koshimizu, Koichi ; Ikeuchi, Masako ; Nakajima, Susumu ; Inui, Hiroshi

A carrier for a new tumor imaging agent, a bifunctional chelating agent (BCA)-coupled porphyrin (ATN-2), has been synthesized from protoporphyrin dimethyl ester in 4 steps. At first, the hydrobromination of protoporphyrin dimethyl ester is carried out to obtain a monobromo derivative. The derivative is treated with ethylene glycol. The resulting porphyrin has an ether group at the either 7- or 12-position of the ring. Metallation with GaCl3 of the porphyrin having a ethylene glycol residue affords Ga-metalloporphyrin. Final condensation of the metalloporphyrin with diethylenetriaminepentaacetic acid (DT-PA) gave BCA-coupled porphyrin (ATN-2). The chelation of ATN-2 with 111InCl3 easily afforded [111In]ATN-2. This agent was used for imaging transplantable pancreatic carcinoma in Syrian golden hamster at 72 h after postinjection. The efficacy of the new agent was compared with that of [67Ga]citrate. The images with [111In]ATN-2 were found to be clearer than those with [67Ga]citrate. Therefore, ATN-2, a carrier for 111InCl3, seems to be more useful for tumor imaging agents.

100 项与 Toyo Hakka Kogyo Co., Ltd. 相关的药物交易

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100 项与 Toyo Hakka Kogyo Co., Ltd. 相关的转化医学

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