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概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

Tubulin(微管蛋白)	1

关联

1

项与 Nowicky Pharma 相关的药物

NSC-631570

靶点

Tubulin

作用机制

微管蛋白抑制剂

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段批准上市

首次获批国家/地区

白俄罗斯

首次获批日期1996-02-01

100 项与 Nowicky Pharma 相关的临床结果

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0 项与 Nowicky Pharma 相关的专利（医药）

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1

项与 Nowicky Pharma 相关的文献（医药）

2016-01-01·Journal of Chromatography A2区 · 化学

Investigation of the composition and antibacterial activity of Ukrain™ drug using liquid chromatography techniques

2区 · 化学

Article

作者: Choma, Irena M ; Majer-Dziedzic, Barbara ; Jesionek, Wioleta ; Fornal, Emilia ; Nowicky, Wassil ; Móricz, Ágnes M

The greater celandine (Chelidonium majus L.) has been known for the centuries as a medicinal plant. One of the therapeutic agents based on C. majus is anticancer drug Ukrain™ known as a semi-synthetic C. majus alkaloid derivative. Although there are no doubts about antitumor properties of the drug, there is still controversy about its composition. In this study, Ukrain™ was subjected to TLC and LC-MS/MS analyses to compare it with C. majus alkaloid root extract and to determine its composition. Moreover, microbiological activity of both Ukrain™ and the alkaloid extract were tested against Bacillus subtilis strains using TLC-direct bioautography. Sanguinarine, chelidonine, α-homochelidonie and chelerythrine were found to have antibacterial properties. Besides chelidonine, sanguinarine, chelerythrine, protopine, allocryptopine, homochelidonie, berberine and coptisine reported earlier in literature, the presence of stylopine, norchelidonine, dihydrochelidonine and hydroberberine in Ukrain™ was detected, and here they have been reported for the first time.

100 项与 Nowicky Pharma 相关的药物交易

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100 项与 Nowicky Pharma 相关的转化医学

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