Puumala Hantavirus Infection in France: Evaluation of Commercial Assays for the Detection of Antibodies Against This Virus and the Use of Urine Samples for the Molecular Detection of This Infection

Routine Puumala virus (PUUV) infection diagnosis is performed using serological commercial kits of which performances have not been established in real life, which use recombinant protein from strains from Central or North Europe. Molecular diagnostic of these infection is not the rule. Consequently the objectives of the project are to evaluate the performances of the serological commercial assays in real life in France and to assess the use of urine versus plasma for the molecular diagnostic of this infection.

开始日期2015-07-01

申办/合作机构

Centre Hospitalier de Charleville-Mézières

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2023-09-01·RMD open

In inflammatory myopathies, dropped head/bent spine syndrome is associated with scleromyositis: an international case-control study.

Article

作者: De Moreuil, Claire ; Bini, Paola ; Dernis, Emanuelle ; Giannini, Margherita ; Codullo, Veronica ; Galempoix, Jean-Marc ; Hervier, Baptiste ; Meyer, Alain ; Cavagna, Lorenzo ; Dubost, Jean Jacques ; Ziane, Rahima ; Mariampillai, Kuberaka ; Séverac, François ; Bouchard-Marmen, Maude ; Bernardi, Livio ; Soulages, Antoine ; Sibilia, Jean ; Diamanti, Luca ; Piot, Jean-Maxime ; Duval, Fanny ; Poursac, Nicolas ; Arnaud, Laurent ; Mosca, Marta ; Barsotti, Simone ; Troyanov, Yves ; Sellam, Jérémie ; Couderc, Marion ; Geny, Bernard ; Sole, Guilhem ; Guichard, Isabelle ; Groza, Monica ; Lebrun, Delphine ; Prieto-González, Sergio ; Viallard, Jean-François ; Nannini, Carlotta ; Selva-O'Callaghan, Albert ; Terrier, Benjamin ; Blagojevic, Jelena ; Vernier, Nathalie ; Bellando-Randone, Silvia ; Tournadre, Anne ; Iannone, Florenzo ; Iaccarino, Luca ; Gottenberg, Jacques-Eric ; Vesperini, Veronique ; Guilpain, Philippe ; Marchioni, Enrico ; Maurier, Francois ; Pijnenburg, Luc ; Guffroy, Aurelien ; Hudson, Marie ; Emmi, Giacomo ; Rouanet, Eglantine ; Nadaj-Pakleza, Aleksandra

BACKGROUNDSome myopathies can lead to dropped head or bent spine syndrome (DH/BS). The significance of this symptom has not been studied in inflammatory myopathies (IM).OBJECTIVESTo assess the significance of DH/BS in patients with IM.METHODSPractitioners from five IM networks were invited to report patients with IM suffering from DH/BS (without other known cause than IM). IM patients without DH/BS, randomly selected in each participating centre, were included as controls at a ratio of 2 to 1.RESULTS49 DH/BS-IM patients (DH: 57.1%, BS: 42.9%) were compared with 98 control-IM patients. DH/BS-IM patients were older (65 years vs 53 years, p<0.0001) and the diagnosis of IM was delayed (6 months vs 3 months, p=0.009). Weakness prevailing in the upper limbs (42.9% vs 15.3%), dysphagia (57.1% vs 25.5%), muscle atrophy (65.3% vs 34.7%), weight loss (61.2% vs 23.5%) and loss of the ability to walk (24.5% vs 5.1%) were hallmarks of DH/BS-IM (p≤0.0005), for which the patients more frequently received intravenous immunoglobulins (65.3% vs 34.7%, p=0.0004). Moreover, DH/BS-IM patients frequently featured signs and/or complications of systemic sclerosis (SSc), fulfilling the American College of Rheumatology/European Alliance of Associations for Rheumatology criteria for this disease in 40.8% of the cases (vs 5.1%, p<0.0001). Distribution of the myopathy, its severity and its association with SSc were independently associated with DH/BS (p<0.05). Mortality was higher in the DH/BS-IM patients and loss of walking ability was independently associated with survival (p<0.05).CONCLUSIONIn IM patients, DH/BS is a marker of severity and is associated with SSc (scleromyositis).

2019-05-01·Médecine et Maladies Infectieuses4区 · 医学

Localisation digestive isolée d’un lymphome de Hodgkin chez une patiente infectée par le VIH révélé par une hémophagocytose lymphohistiocytaire

4区 · 医学

Article

作者: Delmer, A ; Kheirallah, S ; Cousson, J ; Romaru, J ; Bani-Sadr, F ; Brunet, A ; Lebrun, D

2016-12-01·Joint Bone Spine3区 · 医学

Diagnostic contribution of a second percutaneous needle biopsy in patients with spontaneous diskitis and negative blood cultures and first biopsy

3区 · 医学

Article

作者: Eschard, Jean-Paul ; Ohl, Xavier ; Terreaux, William ; Salmon, Jean-Hugues ; Geoffroy, Marion ; Job, Louis ; Cart, Philippe

OBJECTIVESThe primary objective was to assess the diagnostic contribution of a second percutaneous needle biopsy in patients with spontaneous diskitis and negative findings from blood cultures and the first biopsy. We also assessed the sensitivity of the first biopsy and the diagnostic contribution of post-biopsy blood cultures.METHODSMulticenter retrospective study of patients managed between 2004 and 2014. We excluded patients with postoperative diskitis.RESULTSWe identified 63 patients with spontaneous diskitis, negative blood cultures, and at least one percutaneous needle biopsy during the study period. The first biopsy established the diagnosis in 33 (52%) patients. Of the 30 remaining patients, 10 (33%) had a second biopsy, which was positive in 6 (60%), and 20 (67%) received probabilistic antibiotic therapy. There were 8 positive blood cultures after the first biopsy but, among them, 7 occurred in biopsy-positive patients. Biopsy yield varied with the guidance method (needle guidance software or imaging by computed tomography and/or fluoroscopy) and operators. Antibiotic therapy within the 6months preceding the first biopsy was significantly associated with having a negative first biopsy (15/30 versus 7/33; odds ratio, 3.13; 95% confidence interval, 1.07-9.13; P<0.05).CONCLUSIONIn our study, a second needle biopsy was useful, providing the bacteriological diagnosis in 60% of cases of spontaneous diskitis with negative findings from blood cultures and the first biopsy.

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