Educational-care technological strategy for guidance on self-care, through a chatbot-type mobile application, to Health Care Network and for people with intestinal ostomies in State of Pernambuco

开始日期2024-08-20

申办/合作机构

Fundação Universidade de Pernambuco

NCT06296381 / RecruitingN/AIIT

Analysis of Peripheral Muscle Strength Measurement Methods in Healthy Individuals and Critical Patients: A Health Technology Assessment

Muscle strength is an important indicator of overall health and is a factor that has been associated with increased mortality in critical patients. Its measurement must be reliable and reproducible to ensure a quality outcome for clinical applicability. Recently, the use of digital handheld dynamometers in intensive care has gained support; however, analysis becomes challenging due to the absence of standardized reference equations for the Brazilian population. The aim of this study is to develop reference equations for the Brazilian population and define specific cutoff points for men, women, healthy individuals, and critical patients.

开始日期2024-03-01

申办/合作机构

Universidade de Pernambuco

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8,793

项与 Universidade de Pernambuco 相关的文献（医药）

2025-01-01·Brazilian Journal of Otorhinolaryngology

Profile of oropharyngeal swallowing in healthy Brazilian adults and older adults

Article

作者: De Lima Alvarenga, Eliézia Helena ; Haddad, Leonardo ; Alvarenga, Eliézia Helena de Lima ; Dall'Oglio, Giovana Piovesan ; Abrahão, Márcio ; Aires, Mateus Morais

OBJECTIVESTo describe the findings of Fiberoptic Endoscopic Examination of Swallowing (FEES) in asymptomatic young and older adults, comparing results across different age groups. Additionally, this study aims to test the Eating Assessment Tool (EAT-10) as an instrument to identify dysphagia risk.METHODSA prospective cross-sectional observational analysis was conducted on a sample of individuals aged 20 and above, asymptomatic for dysphagia, stratified by age groups. The EAT-10 questionnaire was completed, and the FEES was employed to assess oropharyngeal swallowing function. Various parameters, including salivary stasis, swallowing reflex trigger, swallowing sequence, residue, penetration, and aspiration were blindly analyzed by two otolaryngologists.RESULTSA total of 184 participants were included, with a mean age of 44.7 ± 18.5 years. There was good to excellent agreement between examiners for FEES parameters. The EAT-10 score ≥3 suggested dysphagia risk in 7.6% (n = 14) of the sample, with no association with age or any FEES parameter. Individuals aged ≥80 years presented more residue (50%; n = 5/10) compared to younger individuals (11.5%; n = 20/174; p =  0.039). Salivary stasis was found exclusively in individuals aged ≥60 years (n = 5/39; 12.8%; p = 0.027). Age did not influence on the swallowing reflex trigger, swallowing sequence, penetration, and aspiration. Penetration was observed in 4.9% (n = 9) of subjects and aspiration occurred in 0.5% (n = 1) of subjects, with no statistical significance in age groups.CONCLUSIONAge does not have a linear influence on swallowing in healthy adults and elderly people. However, individuals aged ≥80 years showed a higher prevalence of residue, and individuals aged ≥60 years showed a higher prevalence of salivary stasis, suggesting an increased risk or presence of dysphagia. Other FEES parameters were not influenced by age. These findings provide valuable insights into the nuanced dynamics of swallowing across different age groups, emphasizing the importance of age-specific considerations in dysphagia assessment.LEVEL OF EVIDENCE: 4

2024-12-31·Annals of Medicine

Dialysis parameters associated with SARS-CoV-2 infection and prognosis in end-stage kidney disease

Article

作者: Rodrigues, Cibele I S ; Bezerra, Rodrigo ; Silvestre, Odilson M ; Lima-Filho, Jose L ; Feitosa, Audes D M ; Nadruz, Wilson ; Amazonas, Roberto B ; Sposito, Andrei C ; Teles, Flavio ; Fernandes-Silva, Miguel M

BACKGROUNDThe Covid-19 pandemic has affected patients with end-stage kidney disease (ESKD). Whether dialysis parameters have a prognostic value in ESKD patients with Covid-19 remains unclear.MATERIALS AND METHODSWe retrospectively evaluated clinical characteristics, blood pressure (BP) and dialysis parameters in ESKD patients undergoing maintenance outpatient hemodialysis, with (Covid-ESKD) and without (No-Covid-ESKD) Covid-19, at four Brazilian hemodialysis facilities. The Covid-ESKD (n = 107; 54% females; 60.8 ± 17.7 years) and No-Covid-ESKD (n = 107; 62% females; 58.4 ± 14.6 years) groups were matched by calendar time. The average BP and dialysis parameters were calculated during the pre-infection, acute infection, and post-infection periods. The main outcomes were Covid-19 hospitalization and all-cause mortality.RESULTSCovid-ESKD patients had greater intradialytic and postdialysis systolic BP and lower predialysis weight, postdialysis weight, ultrafiltration rate, and interdialytic weight gain during acute-illness compared to 1-week-before-illness, while these changes were not observed in No-Covid-ESKD patients. After 286 days of follow-up (range, 276-591), there were 18 Covid-19-related hospitalizations and 28 deaths among Covid-ESKD patients. Multivariable logistic regression analysis showed that increases in predialysis systolic BP from 1-week-before-illness to acute-illness (OR, 95%CI = 1.06, 1.02-1.10; p = .004) and Covid-19 vaccination (OR, 95%CI = 0.16, 0.04-0.69; p = .014) were associated with hospitalization in Covid-ESKD patients. Multivariable Cox-regression analysis showed that Covid-19-related hospitalization (HR, 95%CI = 5.17, 2.07-12.96; p < .001) and age (HR, 95%CI = 1.05, 1.01-1.08; p = .008) were independent predictors of all-cause mortality in Covid-ESKD patients.CONCLUSIONAcute Covid-19 illness is associated with variations in dialysis parameters of volume status in patients with ESKD. Furthermore, increases in predialysis BP during acute Covid-19 illness are associated with an adverse prognosis in Covid-ESKD patients.

2024-12-01·Carbohydrate Polymer Technologies and Applications

A review on the use of polysaccharides as thickeners in yogurts

作者: Rodrigues, Natalie Emanuelle Ribeiro ; Silva, Priscila Marcelino dos Santos ; Leal, Makyson Roberto Silva ; Albuquerque, Priscilla Barbosa Sales ; de Oliveira, Weslley Felix ; Kennedy, John F. ; Coelho, Luana Cassandra Breitenbach Barroso ; Correia, Maria Tereza dos Santos

A review.Yogurt is one of the most popular consumed fermented dairy products in the world due to its high nutritional content and considerable benefits to human health.Polysaccharides are a major component associated with their texture and mouthfeel.Composition-wise of yogurts, casein micelles form aggregates with whey proteins in yogurts and then contribute to the formation of a protein gel, which is responsible for the well-known consistency of the yogurt.Food thickening agents are widely used to modify textural, rheol., and physicochem. properties, as well as to enhance the consistency and sensory attributes of yogurts.Improvement in moisture binding capacity, structural modification, and altering flow behavior properties are the major functions of food thickeners.Because of the ability to increase the viscosity of solutions, emulsions, and suspensions, polysaccharides can be considered strong candidates for thickeners in yogurts; however, few studies have focused on this field.Thus, we were directed to write a review article to summarize recent advances in using polysaccharides as thickening agents focusing on the rheol., textural, and microstructural properties of supplemented yogurts.Thus, this review may contribute to the knowledge about the application of polysaccharides in emulsions, mainly in the food industry.

项与 Universidade de Pernambuco 相关的新闻（医药）

2022-06-14

·PRNewswire

Pew apoia 10 cientistas latino-americanos com pesquisas na área de biomedicina

FILADÉLFIA, 14 de junho de 2022 /PRNewswire/ -- A Pew Charitable Trusts anunciou hoje os membros da turma de 2022 do Programa de Bolsas Pew em Ciências Biomédicas da América Latina. Os 10 bolsistas de pós-doutorado de cinco países da América Latina (Chile, México, Argentina, Colômbia e Brasil) receberão apoio financeiro durante dois anos para conduzir suas pesquisas em laboratórios dos EUA. Os bolsistas trabalharão sob a orientação de pesquisadores eminentes em Ciências Biomédicas, incluindo ex-alunos do Programa de bolsistas da Pew de Ciências Biomédicas, do Programa de bolsistas da Pew-Stewart em pesquisa sobre câncer e do Programa de bolsistas da Pew para a América Latina. "A pesquisa biomédica é um esforço global que requer uma comunidade criativa e diversificada de cientistas", disse Susan K. Urahn, presidente e CEO da Pew. "A Pew tem orgulho de receber um grupo tão inovador da América Latina, cujo trabalho explorará novos horizontes na saúde e na medicina." Os bolsistas que optarem por retornar à América Latina para iniciar seus próprios laboratórios de pesquisa receberão fundos adicionais da Pew. Aproximadamente 70% dos participantes seguiram esse caminho, o que ajudou a apoiar uma comunidade de pesquisa biomédica mais robusta na América Latina. Os cientistas da turma de 2022 explorarão diversos tópicos de pesquisa, incluindo como as bactérias formam resistência a antibióticos direcionados ao RNA, como certas reações químicas ajudam os bebês a reconhecer suas mães e como as alterações na manutenção do DNA podem ocasionar a leucemia mieloide aguda. "A turma de 2022 conta com uma comunidade rica de jovens cientistas que são especialistas em suas áreas", comentou Eva Nogales, Ph.D., professora benemérita do Departamento de Bioquímica, Biofísica e Biologia Molecular da Universidade da California, Berkeley e presidente do comitê consultivo nacional do programa. "Ao realizar suas pesquisas nos principais laboratórios dos EUA, esses bolsistas desenvolverão as ferramentas necessárias para liderar a próxima geração de descobertas biomédicas nos EUA e na América Latina." Estes são os bolsistas latino-americanos da Pew de 2022, com seus respectivos mentores nos Estados Unidos: Anibal Arce, Ph.D. Laboratório do Julius Lucks, Ph.D. Universidade Northwestern Anibal Arce, Ph.D., vai explorar o potencial dos RNAs chamados "riboswitches" como alvos de uma nova classe de antibióticos. Noe Baruch Torres, Ph.D. Laboratório da Y. Whitney Yin, M.D., Ph.D. Ramo Médico da Universidade do Texas em Galveston Noe Baruch Torres, Ph.D., vai estudar o replissoma mitocondrial humano, uma estrutura complexa de proteínas especializadas que as células utilizam para copiar o DNA encontrado em suas mitocôndrias. Hector Cuello, Ph.D. Laboratório do Ajit Varki, M.D. Universidade da California, San Diego Hector Cuello, Ph.D., vai investigar o papel que uma proteína receptora chamada Siglec-XII desempenha na progressão do câncer. Mabel Gonzalez, Ph.D. Laboratório da Lauren O'Connell, Ph.D., bolsista de biomedicina da Pew em 2020 Universidade de Stanford Mabel Gonzalez, Ph.D., vai estudar as interações químicas que permitem que os bebês reconheçam suas mães. Krystal Maya-Maldonado, Ph.D. Laboratório da Nichole Broderick, Ph.D. Universidade de Johns Hopkins Krystal Maya-Maldonado, Ph.D., vai explorar como os pais podem transmitir uma "memória imunológica" de infecções passadas às gerações futuras. Vinicius Miessler de Andrade Carvalho, Ph.D. Laboratório do Nirao Shah, Ph.D. Universidade de Stanford Vinicius Miessler de Andrade Carvalho, Ph.D., vai analisar o circuito neural que permite o reconhecimento sexual em animais, informação que determina suas subsequentes interações sociais. Francisco Saavedra Cantillana, Ph.D. Laboratório da Thelma Escobar, Ph.D. Universidade de Washington Francisco Saavedra Cantillana, Ph.D., vai estudar as alterações no panorama da cromatina que levam à leucemia. John James Tello Cajiao, Ph.D. Laboratório do Jorge Henao-Mejia, M.D., Ph.D., bolsista de biomedicina da Pew em 2017 Universidade da Pennsylvania John James Tello Cajiao, Ph.D., vai desenvolver ferramentas analíticas para avaliar como a organização espacial do DNA regula a atividade dos genes. Sergio Heli Triana Sierra, Ph.D. Laboratório do Alex Shalek, Ph.D., bolsista Pew-Stewart em 2018 e da Pardis Sabeti, M.D., Ph.D. Instituto de Tecnologia de Massachusetts Sergio Heli Triana Sierra, Ph.D., vai desenvolver ferramentas para estudar febres hemorrágicas virais em áreas onde essas doenças são endêmicas. Maritere Urióstegui-Arcos, Ph.D. Laboratório da Ana Fiszbein, Ph.D., bolsista latino-americana da Pew em 2017 Universidade de Boston Maritere Urióstegui-Arcos, Ph.D., vai explorar como as sequências de DNA que controlam a atividade de um gene também influenciam quais variantes de RNA o gene irá produzir. A Pew Charitable Trusts é impulsionada pelo uso do conhecimento na resolução dos problemas mais desafiadores da atualidade. Saiba mais em pewtrusts.org. CONTATO: Erin Davis, 202-540-6677, [email protected] FONTE THE PEW CHARITABLE TRUSTS SOURCE THE PEW CHARITABLE TRUSTS

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