This study aims to investigate the knowledge, attitudes and behaviours of the antibiotic resistance and prudent antibiotic use among healthcare workers in Syria

开始日期2024-11-01

申办/合作机构

University of Aleppo

100 项与 University of Aleppo 相关的临床结果

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920

项与 University of Aleppo 相关的文献（医药）

2026-02-01·EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Efficacy and safety of CGRP monoclonal antibodies for migraine prevention in episodic migraine; a network Meta-analysis

Review

作者: Shakir, Ishwa ; Shahzad, Faizan ; Hulou, Saad ; Shahabuddin, Saba ; Khalid, Abdul Rauf ; Shabbir, Haroon ; Shabbir, Ahsan ; Ahmed, Syed Ijlal ; Karamat, Sobia

BACKGROUND AND PURPOSE:

Episodic migraine is a neurological disorder characterized by recurrent, unilateral headaches that significantly impair quality of life. CGRP monoclonal antibodies, targeting calcitonin gene-related peptide (CGRP), have shown efficacy in preventing and treating episodic migraine.

METHODS:

A systematic search of PubMed, Cochrane, and Embase databases was conducted in September 2024 to identify randomized controlled trials (RCTs) on CGRP monoclonal antibodies for episodic migraine. A network meta-analysis was performed to assess efficacy (change in monthly migraine days) and safety (incidence of adverse events). Odds ratios (ORs) and surface under the cumulative ranking curve (SUCRA) were calculated.

RESULTS:

16 studies with 9,123 participants were included. galcanezumab (240 mg) showed the highest efficacy (SMD = 0.5012, p < 0.0001). fremanezumab (225 mg) had the highest odds of ≥ 50% reduction in migraine days (OR = 3.1684, p < 0.0001). erenumab (28 mg) showed the best safety profile (OR = 0.6815, p = 0.2220). fremanezumab ranked highest in both efficacy (SUCRA = 84.6%) and safety (SUCRA = 61.8%).

CONCLUSION:

fremanezumab offers the best balance of efficacy and safety. Further long-term studies are needed.

2026-02-01·Annals of Medicine and Surgery

A 65-year-old male with phosphaturic mesenchymal tumor presenting as tumor-induced osteomalacia: a case report

Article

作者: Khaiata, Hamza ; Abo Dala, Feras ; Kmaleh, Abdulrahman ; Alhamod, Nour ; Sleiay, Bilal ; Alahmad, Rawan

Introduction and importance::

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disorder caused by phosphaturic mesenchymal tumors (PMTs), characterized by chronic hypophosphatemia and impaired bone mineralization.

Case presentation::

A 65-year-old man presented with progressive bone pain lasting 3 years. Laboratory results showed persistent hypophosphatemia and elevated fibroblast growth factor 23. Imaging revealed a hypermetabolic lesion in the left acetabulum. The tumor was surgically resected, and histology confirmed a spindle cell neoplasm without vascular invasion. Serum phosphorus normalized postoperatively, and the patient showed sustained clinical improvement over 1 year.

Clinical discussion::

This case underscores the diagnostic challenges of TIO, often mimicking other metabolic bone diseases and leading to significant delays. Compared with similar reports, our case highlights the utility of combined positron emission tomography and magnetic resonance imaging in localizing PMTs and the dramatic clinical improvement following resection.

Conclusion::

This case underscores the importance of recognizing TIO early to enable effective treatment and avoid prolonged morbidity.

2026-02-01·Saudi Dental Journal

Preparation of clove extract-loaded nano-hydroxyapatite for combating dental caries-associated microbes

Article

作者: Hammal, Abdulrazzaq ; Al-Duihi, Heba Al-Hamed

The global rise in antibiotic resistance among oral pathogens necessitates exploring natural and innovative alternatives for dental caries management. This study aimed to synthesize, characterize, and evaluate a novel clove extract-loaded nano-hydroxyapatite composite (nHA-CE) for its dual functionality: biomimetic remineralization and enhanced antimicrobial activity against dental caries-associated microbes. Nano-hydroxyapatite (nHA) was synthesized via wet chemical precipitation and characterized using XRD, FTIR, AFM, and DLS. Clove extract was obtained by ethanolic extraction and analyzed by GC-MS. The nHA-CE composite was prepared, and its antibacterial efficacy was tested against oral pathogens using agar well diffusion and compared to standard antibiotics. The nHA particles were spherical, with an average size of ~ 80 nm. Eugenol (72.5%) was the major component in clove extract. The nHA-CE composite showed significantly larger inhibition zones against all pathogens, especially Streptococcus mutans (50 ± 0.8 mm), outperforming conventional antibiotics. The composite also exhibited sustained eugenol release and maintained stability over 30 days. The nHA-CE composite is a promising biomaterial for dental caries prevention, combining effective remineralization with potent, broad-spectrum antimicrobial activity, offering a natural alternative to conventional treatments.

项与 University of Aleppo 相关的新闻（医药）

2024-08-08

·PRNewswire

The Inner Circle acknowledges, Gaby Daboul as a Pinnacle Lifetime Member

YONKERS, N.Y., Aug. 8, 2024 /PRNewswire/ -- Prominently featured in The Inner Circle, Gaby Daboul, MD is acknowledged as a Pinnacle Lifetime Member for his contributions in Providing Compassionate Care and Healing Hands in Medicine. Dr. Gaby Daboul, a dedicated physician with a heart for healing, stands as a beacon of compassion and expertise in the field of medicine. With a commitment to providing comprehensive care to adults in the hospital setting, Dr. Daboul's approach is rooted in empathy and treating each patient as a cherished member of the family. Continue Reading Gaby Daboul, MD Originally from Homs, Syria, Dr. Daboul embarked on his journey in medicine with a degree from Aleppo University, Faculty of Medicine in Syria. He then completed his internal medicine residency at Wyckoff Medical Center in Brooklyn, NY. As a board-certified internal medicine physician, Dr. Daboul brings a wealth of knowledge and experience to his practice. He is dedicated to addressing a variety of medical issues, ordering necessary labs and tests, and collaborating closely with surgeons when needed to ensure the best possible outcomes for his patients. Beyond his professional endeavors, Dr. Daboul finds joy and rejuvenation in his hobbies, including meditation, sports, and exercise. These pursuits not only enrich his personal life but also contribute to his holistic approach to patient care, emphasizing the importance of overall well-being. Dr. Daboul's journey in medicine is marked by the unwavering support of his partner and family, particularly two cousins, who have stood by his side throughout his career. Their encouragement and love have been instrumental in his success and dedication to serving others. With a steadfast commitment to providing compassionate care and healing hands, Dr. Gaby Daboul continues to make a meaningful impact in the lives of his patients and the community at large. His unwavering dedication to excellence and empathy serves as an inspiration to all who have the privilege of knowing him. Dr. Daboul expresses gratitude to his family, (particularly his two cousins), and his significant other for all of their support in his career. Contact: Katherine Green, 516-825-5634, [email protected] SOURCE The Inner Circle

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