DUBLIN--(
BUSINESS WIRE
)--The
"Induced Pluripotent Stem Cell (iPSC) Industry Report - Market Size, Trends, and Forecasts, 2024"
report has been added to
ResearchAndMarkets.com's
offering.
This global strategic report reveals all major market competitors worldwide, including their core technologies, strategic partnerships, and products under development. It covers the current status of iPSC research, biomedical applications, manufacturing technologies, patents, and funding events, as well as all known trials for the development of iPSC-derived cell therapeutics worldwide.
Importantly, it profiles leading market competitors worldwide and presents a comprehensive market size breakdown for iPSCs by Application, Technology, Cell Type, and Geography (North America, Europe, Asia/Pacific, and Rest of World). It also presents total market size figures with projected growth rates through 2030.
Since the discovery of induced pluripotent stem cell (iPSC) technology in 2006, significant progress has been made in stem cell biology and regenerative medicine. New pathological mechanisms have been identified and explained, new drugs identified by iPSC screens are in the pipeline, and the first clinical trials employing human iPSC-derived cell types have been initiated. iPSCs can be used to explore the causes of disease onset and progression, create and test new drugs and therapies, and treat previously incurable diseases.
Today, methods of commercializing induced pluripotent stem cells (iPSCs) include:
Cellular Therapy:
iPSCs are being explored in a diverse range of cell therapy applications for the purpose of reversing injury or disease.
Disease Modelling:
By generating iPSCs from patients with disorders of interest and differentiating them into disease-specific cells, iPSCs can effectively create disease models "in a dish".
Drug Development and Discovery:
iPSCs have the potential to transform drug discovery by providing physiologically relevant cells for compound identification, target validation, compound screening, and tool discovery.
Personalized Medicine:
The use of techniques such as CRISPR enable precise, directed creation of knock-outs and knock-ins (including single base changes) in many cell types. Pairing iPSCs with genome editing technologies is adding a new dimension to personalized medicine.
Toxicology Testing:
iPSCs can be used for toxicology screening, which is the use of iPSCs or their derivatives (tissue-specific cells) to assess the safety of compounds or drugs within living cells.
Tissue Engineering:
iPSCs can be seeded onto scaffolds made from biocompatible materials. These scaffolds mimic the structure and properties of the target tissue and can provide a supportive environment for cell growth and differentiation.
Organoid Production:
iPS cells can be coaxed to self-organize into 3D structures called organoids, which mimic the structure and function of organs. Organoids can be used for studying organ development, modeling diseases, and testing drugs.
Gene Editing:
iPS cells can be genetically modified using techniques like CRISPR-Cas9 to correct disease-causing mutations or introduce specific genetic changes. These edited iPS cells can then be differentiated into the desired cell type for transplantation or disease modeling.
Research Tools:
iPSCs and iPSC-derived cell types are being widely used within a diverse range of basic and applied research applications.
Stem Cell Banking:
iPSC repositories provide researchers with the opportunity to investigate a diverse range of conditions using iPSC-derived cell types produced from both healthy and diseased donors.
Cultured Meat Production:
iPSCs are being utilized in clean meat production by serving as the cellular foundation for the creation of lab-grown meat.
3D Bioprinting:
iPSCs can be directed to differentiate into cell types of interest, such as skin, heart, or liver cells, which are then incorporated into bioinks.
Wildlife Conservation and De-extinction Projects:
iPSCs are being used in wildlife conservation and de-extinction projects. For example, Colossal Biosciences is using iPSC technology in an effort to achieve woolly mammoth de-extinction.
Key Topics Covered:
1. REPORT OVERVIEW
2. INTRODUCTION
3. CURRENT STATUS OF IPSC INDUSTRY
3.1 Progress made in Autologous Cell Therapy using iPSCs
3.2 Allogeneic iPSC-based Cell Therapies
3.3 Share of iPSC-based Research within the Overall Stem Cell Industry
3.4 Major Focus Areas of iPSC Companies
3.5 Commercially Available iPSC-derived Cell Types
3.6 Relative use of iPSC-derived Cell Types in Toxicology Testing Assays
3.7 iPSC-derived Cell Types used in Clinical Trials
3.8 Currently Available iPSC Technologies
Nucleofector Technology
Opti-ox Technology
MOGRIFY Technology
Transcription Factor-based iPSC Differentiation Technology
Flowfect Technology
Technology for Mass Production of Platelets
SynFire Technology
4. HISTORY OF INDUCED PLURIPOTENT STEM CELLS (IPSCS)
5. RESEARCH PUBLICATIONS ON IPSCS
6. IPSC: PATENT LANDSCAPE ANALYSIS
6.1 iPSC Patent Applications by Jurisdiction
6.2 iPSC Patent Applicants
6.3 Inventors of iPSC Patents
6.4 iPSC Patent Owners
6.5 Legal Status of iPSC Patents
7. IPSC: CLINICAL TRIAL LANDSCAPE
7.1 Number of iPSC Clinical Trials
7.2 Recruitment Status of iPSC Clinical Trials
7.3 iPSC Clinical Trials Study Designs
7.4 Therapeutic & Non-Therapeutic iPSC Clinical Trials
7.5 iPSC-based Trials by Phase of Study
7.6 iPSC Clinical Trials by Funder Type
7.7 Geographic Distribution of iPSC-based Clinical Trials
7.8 Promising iPSC Product Candidates
CYP-001, CYP-004 & CYP-006 from Cynata Therapeutics
BioVAT-HF from Repairon GmbH
HS-001 from Heartseed
CNTY-101 from Century Therapeutics
FT-576 & FT-819 from Fate Therapeutics
RPE from National Eye Institute
QN-019a from Qihan Biotech
iPSC-CL from Heartworks, Inc.
7.9 Companies having Preclinical iPSC Assets
Aspen Neuroscience
Ryne Biotech
Bluerock Therapeutics
Vita Therapeutics
Hopstem Biotechnology
Res Nova Bio, Inc.
Cytovia Therapeutics
Hebecell Corporation
Sana Biotechnology
SCG Cell Therapy Pte
Cytomed
Shoreline Biosciences
Neukio Biotherapeutics
Exacis Biotherapeutics
CellOrigin Biotech
8. M&A, COLLABORATIONS & FUNDING ACTIVITIES IN IPSC SECTOR
8.1 Mergers and Acquisitions (M&A) Sector
Century Therapeutics & Clade Therapeutics
Evotech & Rigenerand
Fujifilm Corporation & Atara Biotherapeutics
Catalent & RheinCell Therapeutics
Axol Biosciences & Censo Biotechnologies
Bayer AG & Bluerock Therapeutics
Pluriomix & Axiogenesis
8.2 Partnership/Collaboration & Licensing Deals in iPSC Sector
Shinobi Therapeutics & Panasonic
SCG Cell Therapy and A*STAR
Charles River Laboratories & Pluristyx, Inc.
Pluristyx, Inc. & National Resilience, Inc.
University of Texas & GeneCure
Heartseed, Inc. & Undisclosed Biotech
Bluerock Therapeutics & Bit.bio
Applied Stem Cell, Inc. & CIRM
Resolution Therapeutics & OmniaBio, Inc.
REPROCELL, Inc. & CIRM
REPROCELL, Inc. & BioBridge Global
Elevate Bio & CIRM
Evotec & Sernova
Evotec & Almiral
Quell Therapeutics & Cellistic
MDimmune & YiPSCELL
Edigene & Neukio Biotherapeutics
Matricelf & Ramot
Evotec & Boehringer Ingelheim
Pluristyx, Pancella & Implant Therapeutics
Century Therapeutics & Bristol Myers Squibb
Fujifilm Cellular Dynamics & Pheno Vista Biosciences
Metrion Biosciences & Bioqube Ventures
Cytovia Therapeutics & Cellectis
Exacis Biotherapeutics & CCRM
Cynata Therapeutics & Fujifilm Corporation
Bone Therapeutics & Implant Therapeutics
REPROCELL & TEXCELL
Jacobio & Herbecell
NeuCyte & KIF1A.ORG
Kite & Shoreline Biosciences
Neuropath Therapeutics & Hopstem Biotechnology
Allele Biotech & Cellatoz
Bluerock Therapeutics, Fujifilm Cellular Dynamics & Opsis Therapeutics
Newcells & Takeda
Biocentriq & Kytopen
Fujifilm Cellular Dynamics & Sana Biotechnology
Evotec & Medical Center Hamburg-Eppdorf (UKE)
NeuCyte & Seaver Autism Center for Research and Treatment
Cytovia Therapeutics & National Cancer Institute
Mogrify & MRC Laboratory of Molecular Biology
8.3 Venture Capital Funding in iPSC Sector
Asgard Therapeutics
Kenai Therapeutics
Pluristyx
Fujifilm Cellular Dynamics
Mogrify Ltd.
Heartseed, Inc.
Elevate Bio
Aspen Neurosciences
Axol Biosciences
Thyas, Co. Ltd
Synthego
Cellino Biotech, Inc
Curi Bio
Ncardia
Evotec SE
bit.bio
Clade Therapeutics
Shoreline Biosciences
Kytopen
Cytovia Therapeutics & CytoLynx
TreeFrog Therapeutics
HebeCell Corporation
Neukio Biotherapeutics
Stemson Therapeutics
Vita Therapeutics
Century Therapeutics
Heartseed
Mogrify
Metrion Biosciences
Elevate Bio
Vita Therapeutics
9. GENERATION OF INDUCED PLURIPOTENT STEM CELLS (IPSCS)
9.1 OSKM Cocktail
9.2 Pluripotency-Associated Transcription Factors and their Functions
9.3 Delivery of Reprogramming Factors
9.3.1 Integrating Systems
9.3.2 Non-Integrative Delivery Systems
9.3.3 Comparison of Delivery Methods
9.4 Genome Editing Technologies in iPSC Generation
9.5 Available iPSC Lines and their applications
10. HUMAN IPSC BANKING
10.1 Major Biobanks Storing iPSCs & iPSC Lines
10.1.1 RIKEN
10.1.2 WiCell
10.1.3 Fujifilm Cellular Dynamics, Inc.
10.1.4 Sampled
10.1.5 Coriell Institute for Medical Research
10.1.6 European Bank for Induced Pluripotent Stem Cells (EBiSC)
10.2 Cell Sources for iPSC Banks
10.3 Reprogramming Methods in iPSC Banks
10.4 Ownership and Investments made in iPSC Banks
11. BIOMEDICAL APPLICATIONS OF IPSCs
11.1 iPSCs in Basic Research
11.2 Applications of iPSCs in Drug Discovery
11.3 Applications of iPSCs in Toxicology Studies
11.4 Applications of iPSCs in Disease Modeling
11.5 Applications of iPSCs in Cell-Based Therapies
11.6 Other Novel Applications of iPSCs
12. MARKET ANALYSIS
12.1 Global Market for iPSCs by Geography
12.2 Global Market for iPSCs by Technology
12.3 Global Market for iPSCs by Biomedical Application
12.4 Global Market for iPSCs by Derived Cell Type
12.5 Market Drivers
12.5.1 Current Drivers Impacting the iPSC Market Place
12.6 Market Restraints
13. COMPANY PROFILES
For more information about this report visit
https://www.researchandmarkets.com/r/pf57qx
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