Effectiveness of Momordica Charantia Extract Compared to the Standard Antimalarial Drug Combination Dihydroartemisinin Piperaquine-primaquine in Patients With Uncomplicated Falciparum Malaria, in Sumba Barat Daya District of Indonesia

Currently, the first-line combination of artemisinin, piperaquine and prima-quine is quite effective in controlling malaria, however, the threat of spread of drug-resistant parasites has been reported. A study is conducted to assess the efficacy and safety extract of bitter melon (Momordica charantia/MC) regimens compared to the combination of dihydroartemisinin piperaquine primaquine (DHP+PQ) on the sexual and asexual stage of P. Falciparum uncomplicated in Sumba Barat Daya District, Indonesia

开始日期2022-11-01

申办/合作机构

Pancasila University

NCT06036030 / Completed临床2期IIT

Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West Papua

Comparing the efficacy of the combination treatment of bitter melon fruit extract (Momordica charantia) with primaquine (MC+PQ) against the combination of dihydroartemisinin + piperaquine + primaquine (DHP+PQ) on patients with Plasmodium falciparum and Plasmodium vivax without complications in Manokwari, West Papua, Indonesia. The research was conducted from January 2019 to April 2019 at Manokwari Regional General Hospital, West Papua. Open label, 2 parallel randomized clinical studies with Plasmodium falciparum malaria patients without complications (Study 1) and patients with Plasmodium vivax malaria without complications (Study 2). The randomized clinical trial divided in 2 treatment groups, namely the MC+PQ and DHP+PQ. The Success of the treatment was determined by the combination of blood schizontocidal therapy in radical cure. The overall final assessed results were the average value of parasitological failure, hematological measurements, liver function, kidney function, blood lipid levels, blood glucose levels and adverse events until day 42.

开始日期2019-01-11

申办/合作机构

Pancasila University

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2024-12-01·Case Studies in Chemical and Environmental Engineering

Initial mechanical properties of orange peel waste as raw material for vegan leather production

作者: Rimantho, Dino ; Sundari, Anggina Sandy ; Chaerani, Laela

This study promotes the utilization of novel substances for repurposing orange peel waste as a component in vegan leather productionThe results indicate that the test specimen that utilizes Pomelo dressing as reinforcement has the most pronounced influence.The tensile test value for grapefruit with dressing as reinforcement is around 472 N/cm2.It exhibits an elongation value of approx. 67.28 %, the greatest among sweet oranges using dressing as reinforcement.Addnl., the tear resistance of grapefruit with dressing as reinforcement is approx. 14.28 N/cm2.These findings show that recycling organic orange peel waste as vegan leather material has the potential for further development.This article could be the basis for creating environmentally friendly materials and advancing the fake leather industry.

2024-07-01·South African Journal of Botany

Synergistic effect on tyrosinase inhibition of Cassia fistula flower with Gynura procumbens leaf extracts

作者: Rosiana, Vera ; Taurhesia, Shelly ; Djamil, Ratna

The antioxidants and tyrosinase inhibitors found in plants are promising agents in skincare products.Cassia fistula and Gynura procumbens are tropical plants found in many Southeast Asian countries.This study evaluated the antioxidant and tyrosinase inhibitory activities of ethanol extracts prepared from Cassia fistula flowers and Gynura procumbens leaves.The antioxidant activity of Cassia fistula flower and Gynura procumbens leaf extracts were investigated via the stable free radical 2,2-diphenyl-1-picrylhydrazyl method.The tyrosinase inhibitor effects of extracts and its combination against tyrosinase were examined with L-DOPA as substrate.The synergistic effect of Cassia fistula flower and Gynura procumbens leaf extracts combination was demonstrated by using the combination index method based on the median-effect principle that allows quant. determination of its combination, where CI < 1, =1, and >1 indicates synergism, additive effect and antagonism, resp.The CompuSyn software was used for determining synergism and antagonism at all concentrations or effects levels simulated automatically.The antioxidant activity of Cassia fistula flower extract was 2.7-fold higher than Gynura procumbens leaf extract, but the tyrosinase inhibitor activity was lower.The combination of Cassia fistula extract and Gynura procumbens extract in ratio 7:1.2 demonstrated synergistic effects when the inhibition was greater than 50% with the CI ranged 0.90 to 0.49 for the fractional inhibition of Fa = 0.50-0.95.In conclusion, this combination demonstrated a synergistic effect and may be used further in cosmetic formulation.

2024-06-01·International Journal of Thermophysics

Experimental Study on the Effect of Different HTF Discharges to Increase Efficiency of a Latent Heat Storage System Using a Spiral Coil Heat Exchanger with Different Fins

作者: Kurniawan, Yoga ; Ismail, Ismail ; Syahbana, M. Syukur L.

The heat storage system (HHS) still faces the problem of void formation as a result of the supercooling phenomenon caused by the use of paraffin.This study was conducted to analyze the effect of HTF discharge variation in the HHS system on the increase of heat storage efficiency in both the charging and discharging processes.The prototype helical coil heat exchanger is designed, fabricated, and exptl. analyzed on 4 types of helical coils with different models of fin designs: finless helical coil, straight fin, branched fin, and crossed fin.The phase change material (PCM) used is 9 kg of com. paraffin type.The heat transfer fluid (HTF) is SAE 20W40 oil which is heated to a temperature of 210°C with the heat source coming from the heating element.The pump is used to circulate the HTF with an output of 10 mL·s^-1, 11 mL·s^-1, and 12 mL·s^-1.The exptl. results show that the variation of the HTF flow rate affects the melting temperature, the paraffin freezing temperature, and the power efficiency of the LHS.The highest temperature absorption by paraffin was achieved by the branch fin model at 124°C with a discharge of 11 mL·s^-1, and the highest temperature release in the Branch Fin at 90°C with a discharge of 12 mL·s^-1.The highest effective power achieved by the branched fin model with effective power of 73% charge and 53% discharge occurred at a discharge of 12 mL·s^-1.Varying the HTF discharge makes a pos. contribution to the charge/discharge pattern, so it can be used as a reference for latent heat storage models.

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