It was hypothesized that aerobic exercise with blood flow restriction (BFR) induced post exercise hypotension (PEH), and the reduction in blood pressure (BP) was due to peripheral vasodilation via the histamine receptors. Ten male participants participated in this study. The participants were randomly assigned to walk for 10 minutes at 6.4 k/m, 0% grade with or without BFR after taking histamine receptor blockade. Following exercise, BP was measured at 10 min interval for 60 minutes. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure (MAP), and total peripheral resistance (TPR) were evaluated.

开始日期2024-04-01

申办/合作机构

California Baptist University

NCT05945771 / CompletedN/AIIT

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

开始日期2022-05-01

申办/合作机构

California Baptist University

NCT06428890 / CompletedN/AIIT

Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension

This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.

开始日期2022-03-01

申办/合作机构

California Baptist University

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项与 California Baptist University 相关的文献（医药）

2024-08-01·European journal of applied physiology

New Zealand blackcurrant extract modulates the heat shock response in men during exercise in hot ambient conditions

Article

作者: Hill, Garrett W ; Flood, Tessa R ; Willems, Mark E T ; Lee, Ben J ; Conrad, Nathan J ; Costello, Rianne ; Walker, Ella F ; Gillum, Trevor L ; Heckler, Emerson P ; Kuennen, Matthew R ; Wheeler, Lucy E V

Abstract:

Purpose:

To determine if 7d of New Zealand blackcurrant (NZBC) extract alters the heat shock, inflammatory and apoptotic response during prolonged exertional-heat stress.

Methods:

Ten men (Age: 29 ± 2 years, Stature: 1.82 ± 0.02 m, Mass: 80.3 ± 2.7 kg, V̇O2max: 56 ± 2 mL·kg−1·min−1) ingested two capsules of CurraNZ™ (NZBC extract: 210 mg anthocyanins·day−1) or PLACEBO for 7d prior to 1 h treadmill run (65% V̇O2max) in hot ambient conditions (34 °C/40% RH). Blood samples were collected before (Pre), immediately after (Post), 1 h after (1-Post), and 4 h after (4-Post) exercise. Heat shock proteins (HSP90, HSP70, HSP32) were measured in plasma. HSP and protein markers of inflammatory capacity (TLR4, NF-κB) and apoptosis (BAX/BCL-2, Caspase 9) were measured in peripheral blood mononuclear cells (PBMC).

Results:

eHSP32 was elevated at baseline in NZBC(+ 31%; p < 0.001). In PLACEBO HSP32 content in PBMC was elevated at 4-Post(+ 98%; p = 0.002), whereas in NZBC it fell at Post(− 45%; p = 0.030) and 1-Post(− 48%; p = 0.026). eHSP70 was increased at Post in PLACEBO(+ 55.6%, p = 0.001) and NZBC (+ 50.7%, p = 0.010). eHSP90 was increased at Post(+ 77.9%, p < 0.001) and 1-Post(+ 73.2%, p < 0.001) in PLACEBO, with similar increases being shown in NZBC (+ 49.0%, p = 0.006 and + 66.2%, p = 0.001; respectively). TLR4 and NF-κB were both elevated in NZBC at PRE(+ 54%, p = 0.003 and + 57%, p = 0.004; respectively). Main effects of study condition were also shown for BAX/BCL-2(p = 0.025) and Caspase 9 (p = 0.043); both were higher in NZBC.

Conclusion:

7d of NZBC extract supplementation increased eHSP32 and PBMC HSP32 content. It also increased inflammatory and apoptotic markers in PBMC, suggesting that NZBC supports the putative inflammatory response that accompanies exertional-heat stress.

2024-08-01·Metabolic syndrome and related disorders

The Physical Activity Guidelines and Diabetes-Related Mortality: National Health and Nutrition Examination Survey 1999–2006

Article

作者: Ehrlich, Samantha F. ; Boyer, William R. ; Brenton, Madison ; Churilla, James R. ; Fitzhugh, Eugene C.

Background: Previous studies have indicated an inverse relationship between aerobic physical activity (PA) and risk of diabetes-related mortality (DRM). However, the contribution of aerobic PA across multiple domains, while also considering the contribution of muscle-strengthening activity (MSA), in reduction of risk for DRM has yet to be examined. Purpose: The aim of this study is to examine the individual and combined associations of aerobic PA and MSA with DRM. Methods: The study sample (n = 13,350) included adult (20-79 years of age) participants from the 1999 to 2006 National Health and Nutrition Examination Survey. PA was categorized into 6 categories based around the 2018 PA guidelines: category 1 (inactive), category 2 (insufficient aerobic PA and no MSA), category 3 [active (aerobic) and no MSA], category 4 (no aerobic PA and sufficient MSA), category 5 (insufficient aerobic PA and sufficient MSA), and category 6 (meeting both recommendations). The dependent variable in this study was DRM, which includes those who had diabetes as the primary cause of death as well as those with diabetes listed as an underlying cause of death. Cox proportional hazards models were used for all analyses. Results: Following adjustment for covariates, significant risk reductions for DRM were found only in category 3 (HR = 0.57; 95% confidence interval: 0.37-0.88). Conclusions: Results suggest that meeting the aerobic PA guidelines significantly reduces the risk for DRM. Those meeting versus not meeting the MSA guidelines seem to have no difference in risk for DRM independent of aerobic PA.

2024-08-01·JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

Caffeine has no effect on submaximal running in hypoxia in low caffeine consuming males and females

Article

作者: Gillum, Trevor L ; Lira, Albert A ; Almond, Danee G ; Boyer, William R ; Lutz, Christen J ; Kuennen, Matthew R ; Magaña, Marc A ; Apilado, Alvin J ; Gorini Pereira, Felipe L ; Kim, Jong-Kyung

BACKGROUND:

Exposure to hypoxia immediately challenges a variety of physiologic systems that limit exercise capacity. Under normoxia, caffeine (CAFF) increases ventilation and subsequent oxygenation of hemoglobin (SpO2) and skeletal muscle (SmO2). CAFF improves exercise performance at altitude. However, little attention has been given to submaximal exercise in hypoxia, particularly regarding low CAFF consumers and female participants. The aim of this study was to determine the effect of CAFF on pulmonary, metabolic, and perceptual variables in response to submaximal running in hypoxia in low CAFF consuming males and females.

METHODS:

In a double blinded, counterbalanced design, 14 (6 females) individuals (24.1±5.1 years; VO2max: 40.6±5.6 mL × kg^-1 × min^-1; 20.8±8.0% body fat), who habitually consumed ≤150 mg/day of CAFF performed treadmill running at workloads of 25%, 40%, 60%, and 75% of sea level VO2max in normobaric hypoxia (FIO2=0.15) on two separate occasions: 1) 60 minutes after 6 mg/kg of CAFF; or 2) placebo.

RESULTS:

CAFF had no effect on any variable measured. Specifically, VE (condition: P=0.12; interaction: P=0.19), VT (condition: P=0.16; interaction: P=0.57), and Ve:VO2 (condition: P=0.07; interaction: P=0.69) were similar between groups. Further, CAFF had no effect on relative VO2 (condition: P=0.84; interaction: P=0.95), HR (condition: P=0.28; interaction: P=0.35), SmO2 (condition: P=0.66; interaction: P=0.82), or SpO2 (condition: P=0.16; interaction: P=0.97). Finally, rating of perceived exertion (RPE; P=0.92) and acute mountain sickness scores (P=0.29) were similar across conditions.

CONCLUSIONS:

These data demonstrate that CAFF provides no physiologic advantage to submaximal exercise in acute, normobaric hypoxia with low CAFF consuming males and females.

项与 California Baptist University 相关的新闻（医药）

2022-09-26

·PRNewswire

HILINSKI'S HOPE TEAMS UP WITH MORE THAN 115 SCHOOLS FOR COLLEGE FOOTBALL MENTAL HEALTH WEEK

College Football Mental Health Week kicks off October 1 week of education & action NEW YORK, Sept. 26, 2022 /PRNewswire/ -- Hilinski's Hope Foundation (H3H), founded by Mark and Kym Hilinski to honor the legacy of their son Tyler, today announced that 115+ schools around the country will be participating in the third annual College Football Mental Health Week. The week will focus on a series of mental health initiatives, beginning October 1, which will honor Tyler, those lost, and those suffering, and will culminate on October 8. Continue Reading Hilinski's Hope College Football Mental Health Week 2022 "We are incredibly honored that over 115 schools nationwide will be participating in this year's mental health week to fight stigma and increase resources on campuses," said Kym Hilinski, co-founder of Hilinski's Hope. "While conversations around mental illness can be tough and at times uncomfortable, it is absolutely critical for the well-being of our student athletes. We have spoken on dozens of campuses to help encourage these conversations and share Tyler's story. We miss Tyler every day, but we are grateful to know that what we are doing is making a difference and that he would be proud of us." Coaches and players nationwide have come together to eliminate the stigma and increase mental health resources at their universities and colleges. This week they'll participate in breaking down stigma, offering quality resources, and letting student athletes know that they care. "The health and wellbeing of our players has always been one of our top priorities at The University of Alabama," Crimson Tide head coach Nick Saban said. "We are proud to partner with Hilinski's Hope as they strive to provide practical tools to student-athletes across the country. Together, our goal is to positively affect the way mental health is viewed and treated in college athletics. Our hope is that every institution will join us in working to provide the best mental care for all student-athletes." "Talking about your mental health takes guts," said Ryan Hilinski, QB of Northwestern University and Allstate American Football Coaches Association Good Works Team member. "It shows strength to be vulnerable, but that is what is needed to be real with your teammates, coaches, and family. I'm proud of my family for creating College Football Mental Health Week to help all student athletes to know that they are not alone." Participating schools have committed to at least one of the following during the week: showcasing a lime green ribbon on all players helmets with a "3" in the middle to honor Tyler Hilinski and remember those lost and those suffering in silence; encouraging students, parents, alumni, and fans to participate in showing solidarity, eliminating stigma around mental health by holding three fingers in the sky during the first play of the third quarter; playing a Hilinski's Hope PSA at the CMHW games; participating in Hilinski's Hope's: Online Mental Health Course to help reduce the stigma of seeking help for mental health concerns, and provides a new way of thinking about mental health; participating in a social media campaign; participating in an internal assessment to evaluate how universities are following best practices in terms of mental health programs and include talks and trainings on campus for players, coaches, and staff. Hilinski's Hope would like to say a special thank you to our lead sponsor Amwell® and additional supporters Christie Campus Health, Lombardi Wines, Beacon Health, and Stockham Construction for helping us make College Football Mental Health Week possible. To learn more and/or get involved with Hilinski's Hope Foundation please visit . To date schools from around the country are participating including: Arizona State University Auburn University Baylor University Bemidji State University Benedict College Berry College Boise State University Boston College Brigham Young University Brookdale Community College California Baptist University (WAC) California State University, Bakersfield (WAC) Carroll College Central College Chicago State University (WAC) Claremont Mudd Scripps Colleges Clemson University Concordia University Chicago Cornell University Davidson College Drake University Duquesne University Eastern Washington University Florida Atlantic University Florida State University Gardner-Webb University George Fox University George Mason University Georgetown University Georgia Southern University Grand Canyon University (WAC) Henderson State University Idaho State University Illinois State University Indiana University James Madison University Kansas State University Lamar University Lehigh University Liberty University Louisiana State University Louisiana Tech University Marist College Mercyhurst University Middlebury College Mississippi College Mississippi State University Missouri State University Mt San Antonio College New Mexico State University (WAC) North Carolina State University North Dakota State University North Greenville University Northern Arizona University Northwestern University Oklahoma State University Oregon State University Pacific Lutheran University Pomona-Pitzer Colleges Sacramento State University Saint Xavier University Seattle University (WAC) Southern Methodist University Southern University and A&M College Stanford University Stetson University Stevenson University Stony Brook University Tarleton State University Texas A&M University Texas Tech University Thiel College Tufts University Football University at Buffalo University of Akron University of Alabama University of Arizona University of Arkansas University of California, Berkeley University of California, Santa Barbara University of Colorado, Boulder University of Dayton University of Delaware University of Detroit, Mercy University of Georgia University of Hawaii University of Kansas University of Massachusetts - Amherst University of Miami University of Mississippi University of Missouri University of Missouri-Kansas City (WAC) University of Montana Western University of Nevada, Las Vegas University of Nevada, Reno University of North Carolina, Greensboro University of North Texas University of Redlands University of Richmond University of San Diego University of South Carolina University of South Carolina, Beaufort University of South Dakota University of South Florida University of Southern California University of Tennessee Knoxville University of Texas Rio Grande Valley (WAC) University of Tulsa University of Utah University of Washington University of Wyoming Utah State University Utah Valley University (WAC) Vanderbilt University Washington State University West Virginia University Western Carolina University Whitworth University William Penn University About Hilinski's Hope: H3H helps colleges and universities save lives, eliminate stigma, and scale mental wellness programs for student athletes. H3H does this by sharing Tyler's story, connecting students with mental health resources, and assisting universities to institutionalize best practices. To learn more about H3H please visit SOURCE Hilinski's Hope Foundation