This cross-sectional observational study aims to determine the prevalence of Persistent COVID-19 in 282 individuals in Punta Arenas, Magallanes and Chilean Antarctic Region. Persistent COVID-19 is a complex array of symptoms that persist or emerge for more than 4 weeks beyond SARS-CoV-2 infection. Recent studies suggest that up to 80% of survivors may develop chronic multi-organ dysfunction due to persistent inflammation and immune dysregulation, making it an ongoing public health concern worldwide.
The study aims to (1) describe and establish the frequency of physical and psychological signs and symptoms in adult patients who have tested positive for COVID-19, (2) identify individuals who meet the WHO case definition of Persistent COVID-19 in Chile, (3) explore risk factors associated with persistent COVID-19 to guide intervention strategies, and (4) explore inflammatory and molecular biomarkers associated with persistent COVID-19.
The research project utilizes a stratified random sampling with a mixed-methods embedded design. In the first phase, individuals diagnosed with COVID-19 will be recruited and followed up to complete the study's sample universe. A sociodemographic survey, blood sampling (including complete blood count, biochemical profile, immunoglobulin mutational status analysis, and analysis of inflammatory biomarkers), and a battery of psychological tests will be administered. In the second phase, kinesiology studies and medical consultation and evaluation will be conducted to determine if individuals have Persistent COVID-19 and to derive them to the healthcare network. In the final follow-up phase, participants diagnosed with Persistent COVID-19 will be invited to undergo musculoskeletal and respiratory assessments to complete the diagnosis of symptoms associated with the pathology.

开始日期2023-05-15

申办/合作机构

Universidad de Magallanes

[+2]

NCT05932797 / Active, not recruitingN/AIIT

EVALUATION AND IMPLEMENTATION OF A MULTIMODAL INTERVENTION TO REDUCE SYMPTOMS OF LONG COVID/PROLONGED COVID IN THE ADULT POPULATION OF PUNTA ARENAS, CHILE.

Due to the COVID-19 pandemic, the world has seen the need to identify groups of patients who experience various effects in the medium and long term after recovering from the initial illness. These medium- and long-term effects are collectively known as the post-COVID-19 condition, Long-COVID, or prolonged COVID. Current evidence indicates, with conservative estimates, that between 10% and 20% of the population could be affected. Its nature is varied and ranges from physical conditions such as chronic fatigue, dyspnea and muscle weakness, to neurocognitive (compromised memory, decreased concentration) and psychological (anxiety, depression, anguish, stress). Early recognition and treatment of this symptom burden is essential for physical recovery and mental health. Due to its multivariate nature, it has been suggested that optimal recovery of patients' quality of life would only be achieved to the extent that their main symptoms are addressed from an interdisciplinary perspective.

开始日期2023-05-03

申办/合作机构

Universidad de Magallanes

NCT05598892 / CompletedN/AIIT

Hand Rehabilitation Based on a RobHand Exoskeleton in Stroke Patients: a Case Series Study

The following study seeks to provide information regarding to the RobHand exoskeleton for hand neuromotor maintenance and/or rehabilitation, developed by the University of Valladolid, Spain.

开始日期2021-03-01

申办/合作机构

Universidad de Magallanes

[+1]

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0 项与 Universidad de Magallanes 相关的专利（医药）

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1,849

项与 Universidad de Magallanes 相关的文献（医药）

2024-11-01·Journal of Environmental Management

Social-ecological resilience: Knowledge of agrobiodiversity by campesinos and migrants in the face of global changes

Article

作者: Caviedes, Julián ; Marchant, Carla ; Monterrubio-Solís, Constanza ; Barreau, Antonia ; Ibarra, José Tomás

There is concern that agrobiodiversity is being irreversibly eroded in the face of agricultural industrialization. While academic and policy debates stress loss of landraces, little attention has been paid to evaluating how agricultural knowledge systems endure in response to broader social-ecological changes (i.e., "system's resilience"). For being resilient, agricultural knowledge systems should incorporate new information (modern seed varieties) whilst maintaining its traditional components (landraces) and functions. However, the loss or continuing utilization of landraces may be influenced by several social-ecological filters, which are processes that selectively remove varieties according to their phenotype, local uses, or value. We examined the resilience of agricultural knowledge systems in the southern Andes. These systems include the knowledge of landraces and modern varieties by campesinos and lifestyle migrants. We further assessed the association of social-ecological filters with the knowledge of agrobiodiversity. Over four years (2018-2022), we used mixed-methods including semi-structured interviews with gardener experts and conducted knowledge exercises of seed varieties and surveys of gardeners (n = 132). We assessed the association of 'knowledge score on varieties' (general, landraces, and modern) with a priori-defined social-ecological filters. Gardeners with more proficient knowledge of landraces were more knowledgeable of modern varieties too. The general knowledge of agrobiodiversity and the knowledge of landraces, but not of modern varieties, was higher for campesinos than migrants. The main seed source of gardeners, the participation in seed exchanges, gardeners' origin, and gardeners' age were the social-ecological filters that influenced gardeners' knowledge of agrobiodiversity. We highlight that social-ecological, small-scale farming systems, are being resilient when they have the capacity of incorporating new information (knowledge of modern varieties) whilst maintaining their identity (knowledge of landraces) without undergoing a major shift in their basic structures and functions in this Important Agricultural Heritage Site and Global Biodiversity Hotspot, and beyond.

2024-10-01·Vaccine

Iridaea cordata lipid extract associated with the rCP01850 protein of C. pseudotuberculosis elicited a Th1 immune response in immunized sheep

Article

作者: Scholl, Nicole Ramos ; Barbosa, Tallyson Nogueira ; Collares, Tiago Veiras ; Mansilla, Andrés ; Borsuk, Sibele ; de Pereira, Claudio Martins Pereira ; Pegoraro, Henrique Gonçalves ; Ferreira, Marcos Roberto Alves ; Sousa, Fernanda Severo Sabedra ; de Oliveira Silva, Mara Thais ; Seixas, Fabiana Kommling ; Leitte, Fábio Leivas

2024-09-01·Bulletin of the American Meteorological Society

Winter Targeted Observing Periods during the Year of Polar Prediction in the Southern Hemisphere (YOPP-SH)

作者: Bazile, Eric ; Hirasawa, Naohiko ; Cordeira, Jason M. ; Rowe, Penny M. ; Bromwich, David H. ; Doerenbecher, Alexis ; Guyot, Adrien ; Krakovska, Svitlana ; Chyhareva, Anastasia ; Lazzara, Matthew A. ; Colwell, Steven R. ; Manning, Kevin W. ; Carpentier, Scott ; Choi, Taejin ; Cayette, Arthur ; Park, Sang-Jong ; Zhang, Zhenhai ; Zou, Xun ; Haiden, Thomas ; Hirasawa, Naohika ; French, W. John R. ; Wille, Jonathan D. ; Gonzalez-Herrero, Sergi ; Vitale, Vito ; Durán-Alarcón, Claudio ; Alexander, Simon ; Carrasco, Jorge F. ; Massonnet, Francois ; Cordero, Raul R. ; Kawzenuk, Brian ; Ralph, F. Martin ; Chyhareva, Anastasiia ; Sun, Qizhen ; Litell, Mariana Fontolan ; Gorodetskaya, Irina V. ; Imazio, Paola Rodriguez ; Heinrich, Victoria J. ; Powers, Jordan G. ; Norris, Kimberley

AbstractThe Year of Polar Prediction in the Southern Hemisphere (YOPP-SH) held seven targeted observing periods (TOPs) during the 2022 austral winter to enhance atmospheric predictability over the Southern Ocean and Antarctica. The TOPs of 5–10-day duration each featured the release of additional radiosonde balloons, more than doubling the routine sounding program at the 24 participating stations run by 14 nations, together with process-oriented observations at selected sites. These extra sounding data are evaluated for their impact on forecast skill via data denial experiments with the goal of refining the observing system to improve numerical weather prediction for winter conditions. Extensive observations focusing on clouds and precipitation primarily during atmospheric river (AR) events are being applied to refine model microphysical parameterizations for the ubiquitous mixed-phase clouds that frequently impact coastal Antarctica. Process studies are being facilitated by high-time-resolution series of observations and forecast model output via the YOPP Model Intercomparison and Improvement Project (YOPPsiteMIIP). Parallel investigations are broadening the scope and impact of the YOPP-SH winter TOPs. Studies of the Antarctic tourist industry’s use of weather services show the scope for much greater awareness of the availability of forecast products and the skill they exhibit. The Sea Ice Prediction Network South (SIPN South) analysis of predictions of the sea ice growth period reveals that the forecast skill is superior to the sea ice retreat phase.

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100 项与 Universidad de Magallanes 相关的转化医学

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