Assaf Harofeh Medical Center

D-PLEX100 Achieved in Phase 2 Trial Significant Reduction in SSIs in Patients with Multiple Preoperative Risk Factors Versus Standard of Care Results Consistent with SHIELD I Phase 3 Post-hoc Analysis Demonstrating Significant Primary Endpoint Reduction in Patients with One or More patient related Risk Factors PETACH TIKVA, Israel, Jan. 03, 2023 (GLOBE NEWSWIRE) -- PolyPid Ltd. (Nasdaq: PYPD) (“PolyPid” or the “Company”), a late-stage biopharma company aiming to improve surgical outcomes, today announced the peer-reviewed publication of a post-hoc analysis from the previously-completed Phase 2 study of D-PLEX100 for the prevention of surgical site infections (SSIs) in abdominal surgery. The paper, entitled, “Reduction in Surgical Site Infections by Localized Administration with D-PLEX100 in Patients with Multiple Risk Factors Undergoing Colorectal Surgery,” was published in the American Journal of Surgery and can be found here. The Phase 2 trial was a prospective, multicenter, randomized, controlled, single-blind, two arm study and was designed to assess the efficacy and the safety of D-PLEX100 in addition to standard of care (SoC) in preventing superficial and deep SSIs in patients undergoing elective colorectal surgery. This post-hoc analysis was intended to evaluate the effect of D-PLEX100 on SSI incidence in patients with multiple preoperative risk factors. Thirty-day SSI rates were examined in patients in the Intention-to-treat (ITT) population and in those with two or more patient related risk factors. Individual risk factor categories included diagnoses of diabetes, chronic obstructive pulmonary disease (COPD) or a history of smoking, obesity/overweight as defined as a body mass index (BMI) of 25 or more, hypertension, and peripheral vascular disease. The distribution of the assessed risk factors between the D-PLEX100 plus SoC and SoC cohorts was approximately even. Two hundred and one patients were evaluated in the ITT population, 101 in the intervention arm and 100 in the control arm. The study showed a 53% statistically significant relative risk reduction of the SSI rate (superficial and deep) within 30 days post-index surgery in the D-PLEX100 cohort (N=10/101 [9.9%]) compared to SoC (N=21/100 [21%]; p = 0.033). In patients with two or more risk factors, the SSI rate in the D-PLEX100 plus SOC cohort was 15.8% (6/38) compared to 37.5% (15/40) in the SOC alone cohort, demonstrating a statistically significant relative risk reduction of 58% (p = 0.042). “The data from this post-hoc analysis are compelling, demonstrating that D-PLEX100 may be an effective addition to current SSI bundles in patients with increased risk for surgical complications, including SSI,” said Oded Zmora, M.D., colorectal surgeon, Chair of Surgery at Shamir Medical Center, Be’er Ya’akov, Israel and a co-author of this paper. “Importantly, these results are consistent with post-hoc analysis from the recently completed SHIELD I Phase 3 study, which showed that patients with one or more patient related risk factors could potentially benefit from D-PLEX100 and may help address the high unmet need in this vulnerable patient population.” About D-PLEX100D-PLEX100, PolyPid’s lead product candidate, is designed to provide local prolonged and controlled anti-bacterial activity directly at the surgical site to prevent SSIs. Following the administration of D-PLEX100 into the surgical site, the PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients, enabling a prolonged and continuous release of the broad-spectrum antibiotic doxycycline, resulting in high local concentration of the drug for a period of 30 days for the prevention of SSIs, with additional potential to prevent SSIs caused by antibiotic-resistant bacteria at the surgical site. D-PLEX100 received Breakthrough Therapy Designation from the U.S. FDA for the prevention of SSIs in patients undergoing elective colorectal surgery. D-PLEX100 also received three Qualified Infectious Disease Product (QIDP) designations, and three Fast Track designations for the prevention of SSIs in patients undergoing elective colorectal surgery, post-abdominal surgery incisional infection and for the prevention of sternal wound infection post-cardiac surgery. About PolyPidPolyPid Ltd. (Nasdaq: PYPD) is a late-stage biopharma company aiming to improve surgical outcomes. Through locally administered, controlled, prolonged-release therapeutics, PolyPid’s proprietary PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients (APIs), enabling precise delivery of drugs at optimal release rates over durations ranging from several days to months. PolyPid’s lead product candidate D-PLEX100 is in Phase 3 clinical trials for the prevention of soft tissue abdominal and sternal surgical site infections. In addition, the Company is currently in preclinical stages to test the efficacy of OncoPLEX for treatment of solid tumors, beginning with glioblastoma. For additional Company information, please visit http://www.polypid.com and follow us on Twitter and LinkedIn. Forward-looking Statements This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act and other securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses that D-PLEX100 may be an effective addition to current SSI bundles in patients with increased risk for surgical complications, including SSI, that patients with one or more patient related risk factors could potentially benefit from D-PLEX100 and may help address the high unmet need in this vulnerable patient population. Forward-looking statements are not historical facts, and are based upon management’s current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management’s expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company’s reports filed from time to time with the Securities and Exchange Commission (“SEC”), including, but not limited to, the risks detailed in the Company’s Annual Report on Form 20-F filed on February 28, 2022. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements. References and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. PolyPid is not responsible for the contents of third-party websites. Contacts: PolyPid Ltd. Ori WarshavskyCOO – US908-858-5995IR@Polypid.com Investors:Bob YedidLifeSci Advisors646-597-6989Bob@LifeSciAdvisors.com

ICESECRET study interim findings presented at the Urological Association Conference in Eilat, Israel ProSense was found to be a safe and effective treatment method for renal lesions smaller than 5 cm in patients not suitable for kidney-preserving surgery ProSense is approved for the treatment of benign and malignant kidney tumors in the U.S., Europe, and numerous other countries CAESAREA, Israel, Dec. 19, 2022 /PRNewswire/ --- IceCure Medical Ltd. (Nasdaq: ICCM) (TASE: ICCM) ("IceCure" or the "Company"), developer of minimally-invasive cryoablation technology, the ProSense® System that destroys tumors by freezing, today announced interim results from the ICESECRET study for the treatment of patients with small renal masses ("SRM") who cannot be offered kidney-preserving surgery. Data were presented on December 14, 2022 at the Urological Association Conference in Eilat, Israel. The presentation titled "Renal Mass Cryoablation - Interim Analysis ICESECRET Study" was delivered by Dr. Nasir Said of Bnai Zion Medical Center. According to the presentation, out of the 115 patients enrolled, 107 patients (112 lesions) returned for follow-up with a mean duration of 22.8 months and a range 12-60 months. In a subgroup of patients with no previous history of kidney cancer on the same kidney and a lesion ≤3 cm, an 89.5% recurrence-free rate was observed at a mean follow-up time of 22.2 months when the procedure protocol was followed. The recurrence-free rate was 85.1% for the 107 patients (91 patients, including 13 patients who underwent a second cryoablation), at a mean follow-up period of 16.5 months. 5 serious adverse events were reported, 4 of which were of mild severity and were treated conservatively and resolved within 1-5 days, with one severe complication of a new onset of ipsilateral hydronephrosis 7 months after the cryoablation procedure that led to nephrectomy. Cryoablation time and hospitalization time were relatively short, up to approximately 25 minutes and 2 days, respectively. The presentation concluded that, based on these interim results, cryoablation is safe and effective for treating renal masses under 5 cm. According to the American Journal of Roentgenology, small renal masses, which may be malignant or benign tumors in the kidney, have been rising in incidence over the past two decades. According to the American Cancer Society, in 2022, in the U.S., an estimated 79,000 new cases of kidney cancer will be diagnosed, with about 14,000 dying from the disease. Globally, there were more than 430,000 new cases of kidney cancer in 2020 and about 180,000 deaths according to World Cancer Research Fund International. "These impressive interim results demonstrate the value of ProSense for urologists and interventional radiologists as a therapeutic alternative when patients are not eligible for surgery," stated IceCure's Chief Executive Officer, Eyal Shamir. "We believe the findings will support further use of ProSense in the jurisdictions in which our cryoablation system is approved for use with benign and malignant tissues of the kidney. The growing body of data on ProSense's efficacy and safety across a broad range of indications supports commercialization momentum, particularly in facilities that benefit from one device that can be used across multiple specialties." ICESECRET, a prospective, multicenter, single-arm clinical trial is being performed at Bnai-Zion Medical Center, Haifa, Israel, and Shamir Medical Center, Zerifin, Israel, and led by Principal Investigator Prof. Halahmi Sarel. The trial included 115 patients (138 lesions) with localized SRM of ≤5 cm who were treated with ProSense cryoablation under CT guidance. Full engulfment of the renal lesion, including a safety margin of 0.5 cm was achieved in approximately 96% of the procedures where there was no anatomical limitation. Follow-up visits are performed 6 weeks, 6 months, 1 year, and then annually up to 5 years after the procedure. During the follow-up visits, data related to local recurrence, based on CT imaging, is collected. Safety was determined by monitoring procedure-related adverse events throughout the study. About IceCure Medical Ltd. IceCure Medical Ltd. (Nasdaq: ICCM) (TASE: ICCM) develops and markets ProSense®, an advanced liquid-nitrogen-based cryoablation therapy for the treatment of tumors (benign and cancerous) by freezing, with the primary focus areas being breast, kidney, bone and lung cancer. Its minimally invasive technology is a safe and effective alternative to hospital surgical tumor removal that is easily performed in a relatively short procedure. The system is marketed and sold worldwide for the indications cleared to-date by the U.S. Food and Drug Administration and approved in Europe with the CE Mark. Forward Looking Statements This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates" and similar expressions or variations of such words are intended to identify forward-looking statements. For example, IceCure is using forward looking statements in this press release when it discusses: the interim study results for ICESECRET; the value of ProSense for urologists and interventional radiologists as a therapeutic alternative when patients are not eligible for surgery; the Company's belief that the interim results from ICESECRET will support further use of ProSense in the jurisdictions in which the Company's cryoablation system is approved for use with benign and malignant tissues of the kidney; and the commercialization momentum from a growing body of data on ProSense's efficacy and safety. Because such statements deal with future events and are based on IceCure's current expectations, they are subject to various risks and uncertainties and actual results, performance, or achievements of IceCure could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties, many of which are beyond the control of the Company, including those set forth in the Risk Factors section of the Company's Annual Report on Form 20-F for the year ended December 31, 2021 filed with the Securities Exchange Commission (the "SEC") on April 1, 2022, as amended, which is available on the SEC's website, . The Company undertakes no obligation to update these statements for revisions or changes after the date of this release, except as required by law. IR Contact: Ronen Tsimerman email: [email protected] Logo - SOURCE IceCure Medical Ltd

Recently published clinical trial is the first to comprehensively evaluate, diagnose and treat neurological conditions in people experiencing debilitating and lingering COVID-19 symptoms ORLANDO, Fla., July 12, 2022 (GLOBE NEWSWIRE) -- Aviv Clinics highlights a groundbreaking new study that has been published in Scientific Reports, featuring a promising treatment for long COVID symptoms. The study utilizes the most comprehensive evaluation and diagnosis protocol reported in any long COVID study to date. Long COVID, characterized by symptoms that persist more than three months after contracting the virus, affects up to 30% of patients infected by the COVID-19 virus. For millions suffering with long COVID symptoms, the study provides new hope for long-term recovery. The prospective, randomized, double-blind, placebo-controlled clinical trial was designed around hyperbaric oxygen therapy (HBOT) and conducted by the Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center and Tel Aviv University. The study included 73 patients with reported post-COVID-19 cognitive symptoms such as inability to concentrate, brain fog, forgetfulness and difficulty recalling desired words or thoughts. These symptoms had significantly affected their quality of life and persisted for more than three months following an RT-PCR test confirming COVID-19 infection. The study included comprehensive evaluations of participants’ brains with high resolution advanced brain MRI, computerized cognitive testing and comprehensive clinical symptoms evaluation. Participants were divided into two groups: 37 patients received HBOT treatment and 36 were designated into the blinded, sham-controlled group (placebo sessions were received with normal air). Patients and investigators were unaware of their designated treatment protocol. The unique treatment protocol was comprised of 40 daily HBOT sessions, five sessions per week within a two-month period, in which patients entered a multiplace HBOT chamber and breathed 100% oxygen by mask at 2 atmospheres absolute (ATA) for 90 minutes with oxygen fluctuations. The study suggests that the COVID-19 virus can cause chronic brain injury affecting brain regions responsible for cognitive function, mental status and pain interpretation. In the published study, patients treated by HBOT had significant improvement in their global cognitive function and more cognitive improvement related to their specific damaged brain regions responsible for attention and executive function. Significant improvement was also demonstrated in the energy domain, sleep, psychiatric symptoms and pain interference. Participants in the control group, who received only the placebo (sham) treatment, did not experience significant improvement in their persistent long COVID symptoms. The beneficial effects of the unique treatment protocol can be attributed to neuroplasticity and increased brain perfusion in regions associated with cognitive and emotional roles. [See Figures 1 and 2] “The research suggests that the development of post-COVID-19 conditions related to the central nervous system includes direct neurological injury mostly in the frontal lobes – the area of the brain that plays a major role in cognitive and mental functions. Today, we understand that in some patients, the virus can penetrate the brain through the cribriform plate, the part of the skull located just above the nose, and trigger chronic brain injury presented as cognitive decline such as brain fog, loss of concentration and mental fatigue,” said Dr. Shai Efrati, the research group leader, director of the Sagol Center and chair of Aviv Scientific’s Medical Advisory Board. “The study revealed that HBOT can induce structural and functional repair of the damaged regions of the brain and improve the cognitive, behavioral and emotional function of the unfortunate patients suffering from post-COVID-19 conditions.” [See Figures 3 & 4] The protocols and evaluation procedures used in this clinical study are available at Aviv Clinics in central Florida and Dubai and at Shamir Medical Center in Israel. In October 2021, the World Health Organization issued an official definition of long COVID to refer to the range of new, returning or ongoing symptoms after initial COVID-19 infection. The definition includes cognitive dysfunction as one of the common symptoms. A University of Cambridge and Exeter study to further recognize neurological characteristics associated with long COVID reported that 78% of long COVID patients experienced difficulties with concentration, 69% reported brain fog, and 68% reported forgetfulness. With more cases of long COVID being identified across the nation, President Joe Biden recently announced the launch of a national research action plan on long COVID, which calls on the Department of Health and Human Services to expand existing research on the condition and coordinate more care for patients. “Millions of those who have recovered from COVID-19 are experiencing debilitating symptoms which persist for weeks, months or even years following their original infection. Until today, no effective therapy has been suggested. Our research is the first randomized controlled trial to demonstrate a real solution for the long haulers,” said Dr. Amir Hadanny, chief researcher and head of global clinical operations at Aviv Clinics. Long COVID is one of many conditions that can be treated through HBOT. Previous HBOT-specific studies have demonstrated the ability to improve and treat brain injuries such as stroke, traumatic brain injury, age-related cognitive decline and PTSD in treatment-resistant veterans by increasing brain blood flow, generating new neurons and improving brain metabolism. The same mechanisms conducted during these clinical trials have been replicated by Aviv Clinics and are administered under the same strict protocols, with additional cognitive, physical and dietary support provided to patients. Aviv Clinics’ advanced, comprehensive treatment program offers patients holistic care to treat a variety of symptoms related to post-COVID, stroke, traumatic brain injury, concussion, fibromyalgia, PTSD, Lyme disease, or to maintain physical and cognitive performance as a part of the aging process. In addition to the use of HBOT, the Aviv medical team prepares a robust individualized treatment schedule for each client including physical and cognitive training and a dietary plan. The full study is available here. For more on Aviv Clinics, visit aviv-clinics.com. Aviv Clinics Aviv Clinics is the leader in the treatment of age-related cognitive and functional decline and novel applications of hyperbaric oxygen therapy (HBOT) to maximize human performance. Based on an exclusive partnership with the world’s largest hyperbaric medicine and research facility, the Sagol Center at Shamir Medical Center in Israel, Aviv is introducing a global network of clinics delivering the effective, evidence-based Aviv Medical Program. The two- to three-month regimen designed to improve cognitive and physical decline is based on over a decade of research. More than 1,000 patients have been treated worldwide under the scientific leadership of Shai Efrati, M.D., Chair of Aviv Scientific’s Medical Advisory Board and Director of the Sagol Center. Media Contact: Erin Robertson-Davila erobertson@uproarpr.com 904-716-4439 Photos accompanying this announcement are available at: Figure 1 The potential penetration routes of COVID-19 virus to the brain. Once penetrated, the virus can bind and cause damage to neurons and glial cells. Within the blood vessels, the virus can induce thrombus formation causing brain infarcts. Figure 2 The repair mechanisms induced by hyperbaric oxygen therapy are angiogenesis (generation of new blood vessels) and neurogenesis (generation of new neurons). Figure 3 Generation of new nerve fibers (neurogenesis) in the frontal brain regions of a patient with long COVID, pre- and post-HBOT. These regions are responsible for attention, mental state and executive function (capacity to plan, organize, initiate, self-monitor and control one's responses in order to achieve a goal). Figure 4 Improved cerebral blood flow in a patient suffering from post-COVID symptoms.