A comparison of adsorption capacity of chitosan– rhamnolipid–hydrotalcite-like compound composites synthesized by two methods towards highly efficient removal of Cu(II) ions

作者: Li, Yan ; Liang, Yaqin ; Mao, Xiaoming ; Li, Mengzhao

Copper pollution in global water resources is becoming increasingly severe, posing a serious threat to human health and aquatic ecosystems.In this paper, two chitosan (CS)-rhamnolipid (RL)-hydrotalcite-like compound (HTlc) composites, designated as CS@(RL-HTlc) and (RL-HTlc)/CS, were synthesized using two distinct methods: emulsion crosslinking-coprecipitation-ion exchange and coprecipitation-ion exchange-emulsion crosslinking, resp., to investigate their adsorption properties for Cu(II) ions.Characterization revealed that the CS@(RL-HTlc) composite possessed a crosslinked CS core with an RL-HTlc shell structure, while the (RL-HTlc)/CS microsphere exhibited a porous structure with a rough surface.The adsorption properties of these composites for Cu(II) ions were thoroughly investigated and exhibited significantly enhanced adsorption performances due to the synergistic effect between CS and RL-HTlc.Specifically, the coordination of Cu(II) ions with N/O-containing functional groups and the isomorphous substitution of Mg(II) by Cu(II) ions within the HTlc layers.Addnl., the surface-induced precipitation of Cu(OH)₂ was identified as another adsorption mechanism for CS@(RL-HTlc).Interestingly, the (RL-HTlc)/CS composite, with a larger sp. surface area and a lower isoelec. point, exhibited a higher adsorption capacity compared to CS@(RL-HTlc).Moreover, (RL-HTlc)/CS outperformed CS@(RL-HTlc) as a more suitable candidate for repeated use in wastewater treatment.

2025-07-01·European Journal of Medicinal Chemistry

Discovery of 2,4-dianilinopyrimidine derivatives as novel p90 ribosomal S6 protein kinase (RSK) inhibitors

Article

作者: Zhao, Lin ; Sun, Miao ; Han, Chun ; Wu, Lintao ; Zhang, Zhang ; Guo, Chaohua ; Zheng, Xumei ; Li, Jian ; Wang, Zhijun ; Wang, Shijun

RSK, or p90 ribosomal S6 kinase, plays a crucial role in tumor cell proliferation and survival, making it an appealing target for cancer therapies. With the aim to explore novel RSK inhibitors as anticancer agents, a series of 2,4-dianilinopyrimidine derivatives 2b-2n and 3a-3n have been designed and synthesized. Among them, compound 3e displayed substantial kinase inhibitory activity against RSK2 (IC₅₀ = 37.89 ± 3.08 nM) and a potent antiproliferative effect against a range of cell lines, including HeLa, MIA PaCa-2, U937, SW620, HT-29, AGS, and two kinds of EGFR mutant cells (IC₅₀s = 0.189-0.572 μM). Additionally, compound 3e exhibited a high affinity for RSK and effectively inhibited RSK activity in HeLa cells. It triggered significant apoptosis and caused cell cycle arrest in the G2/M phase. Moreover, 3e displayed considerable in vivo anticancer activity while maintaining an acceptable safety profile. These findings imply that compound 3e, featuring a 2,4-dianilinopyrimidine scaffold, could serve as a promising RSK inhibitor for cancer treatment.

2025-06-01·Industrial Crops and Products

The effects of species diversity and co-inoculation with plant growth-promoting rhizobacteria and arbuscular mycorrhizal fungi on the Chinese medicinal plant Codonopsis pilosula “Ludangshen”

作者: Bai, Bianxia ; Ren, Jiahong ; Han, Yanyan ; Cao, Yongqing

"Ludangshen" (Codonopsis pilosula), a medicinal material from Changzhi City, Shanxi Province, China is used extensively in traditional Chinese medicinal practice.Arbuscular mycorrhizal fungi (AMF) are known to promote the growth and development of medicinal plants and enhance the accumulation of their secondary metabolites.The purpose of this study was to clarify the important effects of AMF on the medicinal components and cultivation yield of C. pilosula by investigating the AMF diversity in wild C. pilosula and carry out inoculation tests using AMF and plant growth-promoting rhizobacteria (PGPR) in the laboratoryThe results showed that AMF colonization ratios ranged from 65.33 % to 83.33 %.Seven genera and 32 species of AMF were identified using morphol. methods.The dominant genera were Glomus and Acaulospora, with Glomus versiforme being the dominant species.Fifteen genera were detected using high-throughput sequencing, confirming that Glomus was the dominant genus.The Glomus species represented the biotic factors, while available phosphorus and urease were the abiotic factors that most affected the medicinal effectiveness of "Pingshun ludangshen".The co-application of AMF and PGPR increased plant height and leaf area, and significantly elevated the contents of lobetyolin and atractylenolide III (the two medicinal factors) in C. pilosula.The top-down carbon flow and bottom-up nutrient flow contribute to the establishment of metabolic networks among C. pilosula, AMF, and PGPR.AMF provides an effective solution to the common challenges of low active ingredient content and poor yield faced in the artificial cultivation of medicinal plants by forming a symbiotic relationship with PGPR.

项与长治学院相关的新闻（医药）

2025-04-25

·生物谷

晚讯｜全球TOP100：12家中国器械公司入榜、“药王”K药皮下注射版侵权？Halozyme把默沙东告了

1. 全球TOP100：12家中国器械公司入榜近日，海外医疗器械网站Medical Device and Diagnostic industry发布了全球医疗器械企业TOP 100排名。按照2024年度企业营收情况，进入前十名榜单的企业分别为美敦力、强生、雅培、丹纳赫、Medline Industries、史赛克、西门子医疗、BD医疗、GE医疗、飞利浦。在本次全球TOP100的企业中，有12家中国医疗器械企业入选挺进全球百强。具体包括迈瑞医疗、威高集团、联影医疗、新华医疗、英科医疗、鱼跃医疗、微创医疗、中国同辐、乐普医疗、蓝帆医疗、东富龙科技、安图生物。2. “药王”K药皮下注射版侵权？Halozyme把默沙东告了Halozyme起诉默沙东，指控其K药皮下注射版侵犯多项专利，涉及关键技术酶，可能影响K药未来市场和营收，Halozyme要求高额销售额分成。3. 这款医疗器械国补30%爆卖，无惧关税冲击在沉睡的睡眠健康市场，一款家用医疗器械在电商平台爆卖。得益于最高30%的“国补”，家用无创呼吸机在电商平台销售量大增，怡和嘉业（呼吸机品牌为瑞迈特，目前已经启动公司名和证券简称统一更名为瑞迈特的工作）董事长在采访中表示国补政策对于呼吸机销量提升明显。此前，家用呼吸机在国内渗透率不足1%，国补是家用无创呼吸机市场的助燃剂，随着大众对家用无创呼吸机认知加深，这一市场增长表现亮眼。鱼跃医疗也在半年报中表示，家用呼吸机产品业务规模实现了较好增长。家用呼吸机市场蛋糕在变大，国内企业分到的份额也在变大。根据沙利文数据，2019年，国产龙头瑞迈特的国内市场份额还只有6.1%，2023年已经增加到30.6%。过去，由于国内市场容量有限，国内头部家用呼吸机企业海外市场收入反而比国内高。根据中国海关数据，2024年无创呼吸机出口金额高达27.17亿元。但在关税政策变化背景下，国内市场增长确定性更强。4. 一个月，顶刊+6，浙大医学创新生态催生全球医学突破新动能浙大医学院一个月内在顶刊发表6篇论文，涵盖多种疾病研究。学院鼓励原创探索与跨学科合作，创建良好学术生态，推动基础医学突破和前沿技术转化。其中，徐浩新团队发现溶酶体新氢离子通道，对帕金森病研究有重要意义。5. 这5家高校获批设立合成生物学本科专业教育部批准长治学院、淮阴师范学院、武汉轻工大学、湖南文理学院、深圳理工大学五所高校设立合成生物学本科专业。至此，国内有11家高校开设此专业。6. 荣昌生物获得上百家机构调研，核心管线开发进展成关注焦点荣昌生物获上百家机构调研，关注其核心管线开发进展。RC18、RC48国内外研发进展顺利，涉及多个治疗领域，公司财务状况有所改善，净亏损同比缩小。本文仅用于学术分享，转载请注明出处。若有侵权，请联系微信：bioonSir 删除或修改！

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