Comparative evaluation of ultrasound guided PECS block of the two concentration of levobupivacaine with adjuvant dexmedetomidine in patients undergoing modified radical mastectomy - NIL

开始日期2024-08-30

申办/合作机构

Indira Gandhi Medical College

CTRI/2024/07/070693 / Not yet recruitingN/AIIT

To study the incidence of adverse events during intrahospital transport of critically ill patients A prospective observational study - Nil

开始日期2024-07-31

申办/合作机构

Indira Gandhi Medical College

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874

项与 Indira Gandhi Medical College 相关的文献（医药）

2024-11-01·European Journal of Clinical Pharmacology

Therapeutic drug monitoring in tuberculosis

Review

作者: Sarkar, J ; Sarkar, M

PURPOSETherapeutic drug monitoring (TDM) is a standard clinical procedure that uses the pharmacokinetic and pharmacodynamic parameters of the drug in the body to determine the optimal dose. The pharmacokinetic variability of the drug(s) is a significant contributor to poor treatment outcomes, including the development of acquired drug resistance. TDM aids in dose optimization and improves outcomes while lessening drug toxicity. TDM is used to manage patients with tuberculosis (TB) who exhibit a slow response to therapy, despite good compliance and drug-susceptible organisms. Additional indications include patients at risk of malabsorption or delayed absorption of TB drugs and patients with drug-drug interaction and drug toxicity, which confirm compliance with therapy. TDM usually requires two blood samples: the 2 h and the 6 h post-dose. This narrative review will discuss the pharmacokinetics and pharmacodynamics of TB drugs, determinants of poor response to therapy, indications of TDM, methods of performing TDM, and its interpretations.METHODSThis is a narrative review. We searched PubMed, Embase, and the CINAHL from inception to April 2024. We used the following search terms: tuberculosis, therapeutic drug monitoring, anti-TB drugs, pharmacokinetics, pharmacodynamics, limited sample strategies, diabetes and TB, HIV and TB, and multidrug-resistant TB. All types of articles were selected.RESULTSTDM is beneficial in managing TB, especially in patients with slow responses, drug-resistance TB, recurrent TB, and comorbidities such as diabetes mellitus and human immunodeficiency virus infection.CONCLUSIONTDM is beneficial for improving outcomes, reducing the risk of acquired drug resistance, and avoiding side effects.

2024-09-09·Future Cardiology

Hearts in the sky: understanding the cardiovascular implications of air travel

Review

作者: Pinnamaneni, Sravya ; Aggarwal, Kanishk ; Katoch, Tavishi ; Anamika, FNU ; Jain, Rohit ; Medatwal, Raunak ; Garg, Shreya

Air travel is widely regarded as the safest mode of transportation, with the United States leading in airline passengers. However, travelers with pre-existing heart conditions face acute cardiovascular risks. Flight pilots and cabin crew are particularly vulnerable to air travel's physiological changes, which can significantly impair their health and performance. Cabin pressure differences and reduced oxygen levels at cruising altitudes of 5000-8000 feet make air travel challenging for individuals with underlying cardiac and pulmonary problems. This, along with dry air, sleep deprivation, missed medication and prolonged sitting, can lead to physiological changes. In-flight and pre-flight stressors contribute to increased health issues, and studies show a rise in medical emergencies during flights. Prolonged exposure to the airplane environment can lead to various health issues for pilots and cabin crew. These changes include impaired judgment, cognitive function and discomfort in the sinuses and ears due to pressure differentials. Therefore, thorough medical screening, skilled instrument use and compliance with safety measures are essential to mitigate these risks. This article reviews the cardiac implications of air travel, discussing the underlying pathophysiology, associated risks and preventive measures to ensure safer flights for individuals with cardiovascular diseases.

2024-09-01·Transplantation Proceedings

A Study of Quality of Life of Elderly Live Kidney Donors—An Interview-Based Prospective Follow-Up Study

Article

作者: Singh, Sanjeet Kumar ; Dhayal, Ishwar Ram ; Srivastava, Alok ; Kumar, Ankit ; Sachdeva, Amit ; Rai, Nandan

Quality of life (QoL) is a vital aspect of postdonation amongst donors, especially elderly donors. There is a limited study from India assessing the QoL amongst young live donors (YLD), and no study has been done on the elderly sub-group. This study was undertaken to determine the donors' sociodemographic and essential clinical characteristics, as well as to study the QoL of the live kidney donors and compare the QoL of elderly and young donors. Baseline demographic characters taken from the RTR registration register and SF-36 questionnaire were used to assess the QoL at baseline, discharge post-transplant, 1 month, 3 months, 6 months, and 12 months through an interview. We found that the QoL of the elderly donors in postkidney donation returns to baseline at the end of 6 months in all dimensions of the QoL amongst the North Indian population. The physical function is better amongst elderly donors at the end of 3 and 6 months than among young donors. The study's findings must be propagated to increase the donation of kidneys to older people. This is the first of its kind from India, necessitating further multicentric study.

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