Objective: To explore the correlation between serum dipeptidyl peptidase (DPP)-4 levels and bone mineral d. (BMD) and bone turnover markers in postmenopausal osteoporosis (PMOP) women. Methods: Ninety postmenopausal women were selected as the research objects, and they were divided into normal bone mass group, osteopenia group and osteoporosis (OP) group with 30 cases according to relevant standards The BMD of the 3 groups of subjects was measured and compared by dual-energy X-ray bone densitometer (DXA) scanning, and RIA (RIA) was used to measure the bone turnover markers of the 3 groups of subjects (osteocalcin (OC), type I procollagen N-terminal propeptide (PINP), β-collagen degradation product (β-CTX)) levels were detected and compared, and ELISA (ELISA) was used to detect and compare the serum DPP-4 levels of the three groups of subjects. Spearman correlation anal. was used to analyze the correlation between serum DPP-4 and BMD and bone turnover indicators, and a multivariate Logistic regression model was used to analyze the influencing factors of OP. Results: The age of OP group was significantly higher than that of osteopenia group and normal bone mass group (P < 0.05). The height, weight, and body mass index (BMI) of the OP group were significantly lower than those of the osteopenia group and the normal bone mass group (P < 0.05), uric acid (UA), progesterone (P), testosterone (TS), 25 hydroxy vitamin D3 (25) (OH)D3) levels were significantly lower than the normal bone mass group, the levels of FSH (FSH) and LH (LH) were significantly higher than those of the normal bone mass group, and the levels of UA, P, 25(OH)D3 in the OP group were significant Lower than the osteopenia group, the FSH level was significantly higher than that of the osteopenia group (P < 0.05). The FSH level of the osteopenia group was significantly higher than that of the normal bone mass group (P < 0.05). The BMD of L1-4, femoral neck, GT, Ward triangle, and total hip in the OP group were significantly lower than that of the osteopenia group and normal bone mass. Group (P < 0.05), the bone mass reduction group L1-4, femoral neck, GT, Ward triangle, total hip BMD were significantly lower than the normal bone mass group (P < 0.05), the 3 groups OC, PINP level comparison, and the difference was not statistically significant (P > 0.05). The levels of β-CTX and DPP-4 in the OP group were significantly higher than those in the osteopenia group and the normal bone mass group (P < 0.05), DPP-4 and L1-4 and Ward triangle BMD was significantly neg. correlated (P < 0.05), and DPP-4 was an important risk factor for OP in postmenopausal women (OR=1.049). Weight was a protective factor for OP (OR=0.866). Conclusion: There was no significant correlation between DPP-4 and bone turnover markers in the serum of PMOP patients, but the higher the level of DPP-4, the lower the BMD of L1-4 and Ward triangle.