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A Multi-Center, Open-Label, Single Arm and Flexible Dose Study of the Effectiveness and Safety of Oral Use Lurasidone HCl Tablet (LATUDA®) for 40-160 mg/Day in Subjects With Schizophrenia

The study evaluates the effectiveness and safety of Lurasidone in subjects with schizophrenia over a period of 6 weeks.

开始日期2018-01-03

申办/合作机构

生达化学制药股份有限公司

NCT02151357 / Terminated临床1期

Phase I, Sequential Dose Escalation Clinical Study to Investigate the Safety, Tolerability and Pharmacokinetics of in Patients With Advanced Solid Tumor

Investigate the safety and tolerability of multiple DCBCI0901 infusions in patients with advanced solid tumor
Pharmacokinetic parameters will be calculated for DCBCI0901, if data permit.
Anti tumor activity: The efficacy endpoint will be the overall response rate (ORR) defined as the proportion of patients who continuously receive treatment after Cycle 1 with a best overall response of complete response (CR) or partial response (PR).

开始日期2014-08-19

申办/合作机构

生达化学制药股份有限公司

100 项与生达化学制药股份有限公司相关的临床结果

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0 项与生达化学制药股份有限公司相关的专利（医药）

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1

项与生达化学制药股份有限公司相关的文献（医药）

2014-01-01·Yonsei Medical Journal4区 · 医学

Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model

4区 · 医学

ArticleOA

作者: Lin, Mei-Fung ; Chin, Hung-Yen ; Changchien, Eileen ; Wang, Chin-Jung ; Chiang, Chi-Hsin

PURPOSEThe aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model.MATERIALS AND METHODSWe used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma).RESULTSDiclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs.CONCLUSIONDiclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.

1

项与生达化学制药股份有限公司相关的新闻（医药）

2023-08-15

·米内网

【关注】6亿抗细菌注射剂，浙江药企首家过评

精彩内容日前，国家药监局官网显示，浙江永宁药业的注射用头孢孟多酯钠一致性评价补充申请获批，成为该产品首家过评企业。米内网数据显示，2022年中国公立医疗机构终端注射用头孢孟多酯钠销售额超过6亿元。注射用头孢孟多酯钠竞争格局来源：米内网一键检索注射用头孢孟多酯钠适用于敏感细菌所致的肺部感染、尿路感染、胆道感染、皮肤软组织感染、骨和关节感染以及败血症、腹腔感染等。米内网数据显示，2022年中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院（简称中国公立医疗机构）终端注射用头孢孟多酯钠销售额超过6亿元，其中，浙江永宁药业的市场份额位居第四。注射用头孢孟多酯钠有生达化学制药、湖南科伦制药、苏州二叶制药、石药集团中诺药业(石家庄)等22家企业拥有生产批文，仅有浙江永宁药业过评。浙江永宁药业过评产品情况来源：米内网一致性评价进度数据库截至目前，浙江永宁药业已有注射用盐酸头孢替安、盐酸左西替利嗪片等6款产品过评。此外，注射用头孢呋辛钠和西洛他唑片的一致性评价补充申请在审。资料来源：国家药监局官网、米内网数据库注：米内网《中国公立医疗机构药品终端竞争格局》，统计范围是：中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院，不含民营医院、私人诊所、村卫生室；上述销售额以产品在终端的平均零售价计算。本文为原创稿件，转载请注明来源和作者，否则将追究侵权责任。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092【分享、点赞、在看】点一点不失联哦

一致性评价

100 项与生达化学制药股份有限公司相关的药物交易

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100 项与生达化学制药股份有限公司相关的转化医学

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