Peregrine Holdings Ltd.

– Exclusive worldwide license agreement for antibodies against undisclosed target JERUSALEM, July 25, 2024 /PRNewswire/ -- Nectin Therapeutics, Ltd., a biotechnology company developing novel immunotherapies and antibody drug conjugates (ADC) to address tumor resistance, today announced a global, exclusive license agreement with Immunome Inc. (Nasdaq: IMNM), a biotechnology company focused on developing first-in-class and best-in-class targeted cancer therapies. Under the terms of the license, Immunome received exclusive rights to a panel of antibodies targeting an undisclosed target. "This agreement allows Nectin to realize value while further pursuing and enabling the focus on our first-in-class anti-PVR program (NTX1088) through its ongoing clinical study in tumor types with high unmet need as well as advance our novel ADCs into clinical development. Immunome's leadership team's track record of developing and commercializing novel ADC therapies makes it an ideal partner to advance these promising assets," said Fabian Tenenbaum, Chief Executive Officer of Nectin Therapeutics. "Immunome believes the next generation of transformative antibody drug conjugates will address novel targets by pairing high-quality antibodies with innovative linker-payload technology," said Clay Siegall, PhD, President and Chief Executive Officer of Immunome. "We appreciate the work Nectin has done on these antibodies and look forward to advancing them further." Under the terms of the agreement, Nectin granted Immunome an exclusive, worldwide, all-fields license to monoclonal antibodies that are directed to a single undisclosed target. Immunome will be responsible for the research, development, manufacturing and commercialization of products incorporating these antibodies. Nectin will receive an upfront payment and will be eligible for milestones and royalties. About Nectin Therapeutics, LTD. Nectin Therapeutics is a clinical stage biotechnology company devoted to transforming the lives of cancer patients by leveraging unique insights into Nectin pathways to develop the next generation of immune oncology (IO) therapies and antibody drug conjugates (ADCs). The company's differentiated therapies have the potential to set new standards for efficacy and patient response rates across various difficult-to-treat cancers. Nectin's technology addresses major escape mechanisms of current IO therapies through a diverse pipeline of novel monoclonal antibodies and antibody drug conjugates (ADCs). It has a world-class scientific and management team with deep experience in oncology drug development and successful track records in building biotechnology companies and developing innovative therapies. Nectin Therapeutics is a venture-backed, privately held company, funded by aMoon Fund, Peregrine Ventures, IBF, Integra Holdings, the Myeloma Investment Fund (MIF), GIBF and the Cancer Focus Fund. Nectin Contact: Fabian Tenenbaum Chief Executive Officer [email protected] +1 201 218-1774 SOURCE Nectin Therapeutics

OR-YEHUDA, Israel, July 18, 2024 /PRNewswire/ -- Restore Medical, a pioneering medical device company in the field of interventional cardiology, is proud to announce that it has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration (FDA) for its ContraBand™ device. This designation is specifically for treatment of heart failure with reduced ejection fraction (HFrEF) patients who remain symptomatic despite maximally tolerated guideline-directed medical therapy, without significant pulmonary hypertension or right heart failure. FDA's Breakthrough Device Designation program is intended to expedite the development and review of medical devices that offer significant advantages over existing treatments for serious or life-threatening conditions. This designation marks a significant milestone in the company's mission towards improvement of cardiac care for heart failure patients as it highlights the potential of the ContraBand™ device to address critical unmet needs in the treatment of HFrEF patients. ContraBand™ is the world's first transcatheter Pulmonary Artery Banding (PAB) system designed specifically for HFrEF patients with the aim of improving the quality of life for these patients. This minimally invasive procedure offers hope to patients suffering from left ventricle failure who currently have limited treatment options. FDA's decision to grant Breakthrough Device Designation was based on compelling results from an ongoing feasibility study demonstrating promising outcomes in safety and efficacy. These results include significant left ventricular volume reduction, improved hemodynamic function, and enhanced physical capacity in patients treated with the ContraBand™ device. About Restore Medical: Restore Medical Ltd. is a privately held company dedicated to revolutionizing the treatment of heart failure. The company was founded by Stephen Bellomo, who serves as CTO, Dr. Elchanan Bruckheimer, who serves as Medical Director, and Aaron Feldman. The company is led by CEO Gilad Marom. Restore Medical is funded by Peregrine Ventures, the European Innovation Council (EIC), and an undisclosed strategic investor, reflecting strong support and confidence in its mission and innovative technology. For more information, please visit: SOURCE Restore Medical Ltd.

NEW YORK, June 27, 2022 /PRNewswire/ -- Cordio Medical, a market-leading medical speech processing platform, announced its latest successful strategic investment round of $18 million from Ceros Financial Services and Peregrine Ventures. Cordio Medical's HearO® product is a unique disruptive solution that converts a smartphone into a medical-grade device. The smartphone app is backed by sophisticated and proprietary algorithms allowing monitoring and early detection of fluid accumulation related to Congestive Heart Failure (CHF) condition deterioration. After a speech sample is collected from the patient's mobile device, the HearO® cloud-based server analyzes the results. If CHF deterioration is discovered, a healthcare professional immediately notifies the patient with an alert. Ceros Capital Markets, the investment banking division of Ceros Financial Services that focuses on fundraising for early-stage medical technology companies, and Peregrine Ventures, Israel's first dedicated healthcare fund, led the latest funding to support a clinical validation study, health and academic partnerships, and sales team recruitment. The ongoing retail and distribution (R&D) of current and future versions of HearO® and clinical operations will be in Israel and the EU. "More than 5.7 million Americans are afflicted with congestive heart failure (CHF), making it one of the most prevalent and costly conditions in the U.S.," said Tamir Tal, CEO of Cordio Medical. "This latest round of funding will allow Cordio Medical to be at the forefront of the MedTech space as the definitive pioneer in leveraging speech processing technologies to monitor CHF. A smartphone running our app for remote monitoring of CHF status will improve patient mortality, quality of life, and contribute to health economic outcomes." "Pioneering advancements in medical technology have opened the doors to personalized care with revolutionary new monitoring and treatment options. Cordio Medical's technology for an easy-to-use smartphone app takes patient care to a new level by providing what we believe is the first non-invasive medical-grade monitoring device for chronic heart conditions," said Mark Goldwasser, CEO of Ceros Financial Services. Cordio Medical seeks to go to market in the U.S. in early 2024 with final approval from the FDA. Eyal Lifschitz, Chairman of Cordio Medical, adds, "HearO® is a digital medical device solution that transforms an off-the-shelf mobile device into a personal and accurate diagnostic tool that will help millions of individuals suffering from CHF across the globe while maintaining a firm business model. It has been an exciting journey with Cordio Medical's fantastic team, and we look forward to the company's continued growth." About Cordio Medical Cordio Medical develops and provides groundbreaking solutions for monitoring health conditions through a patient's speech. Cordio Medical's technologies are based on true speech signal processing technology, unique to each patient, augmented with machine learning capabilities. A patient speaks into a smartphone app backed by sophisticated and proprietary algorithms that allow near real-time monitoring and early detection of condition deterioration. The system is patient-tailored, constantly learning the patient's voice, and provides personalized, seamless, and effortless monitoring. Cordio Medical's goal is to identify and mitigate condition worsening by helping physicians prevent patient deterioration and hospitalization while keeping the patient's wellbeing at the core. For more information on Cordio Medical, go to https://www.cordio-med.com. About Ceros Ceros Financial Services, Inc. Member FINRA/SIPC (www.cerosfs.com), offers comprehensive asset management and mutual fund suite for financial advisors. Ceros services include RIA custody, hybrid advisors, corporate RIA, mutual fund advisory and distribution, and an outsourced trade desk. In addition, Ceros Capital Markets, a division of Ceros Financial, is a digital and traditional platform for the distribution of primary offerings in medical devices and secondaries in unicorns via Special Purpose Vehicles (SPVs). About Peregrine Ventures Peregrine Ventures, Israel's first dedicated healthcare fund, is committed to improving patients' quality of life by investing in and supporting game-changing healthcare opportunities. As a leading global life science venture capital fund, Peregrine invests throughout a company's life cycle to help facilitate growth and success and offers creative business solutions to suit the needs of its portfolio companies. From seed-stage opportunities to more mature companies, Peregrine's specifically defined funds offer portfolio companies complete, end-to-end investment solutions that have helped bring healthcare innovations to fruition for over 20 years. Peregrine's robust portfolio includes fast-growing global companies, many of them with a valuation of hundreds of millions of dollars in the fields of pharma-oncology, medical devices, implants, and digital health. Peregrine's mature funds maintain their strong position in the upper quartile of the industry's leading benchmarks (Number of exits, DPI, IRR, etc.), including 14 successful exits with an accumulated value of more than USD 2 billion. For more information, please visit www.peregrinevc.com.