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Influenza and coronavirus infections are especially dangerous due to being capable of causing pandemics and clin. complications in the nervous and cardiovascular systems, as well as exacerbation of chronic diseases (diabetes mellitus, heart failure, chronic obstructive bronchopneumonia, etc.), which can cause delayed death, especially in children under two years of age, the elderly, and individuals with poor health.The aim of the study was to search for compounds effective against these two topical viruses which possess constant epidemic activity - influenza virus and betacoronavirus - among new adamantane derivatives containing a NO-donor fragment or a dopamine residue.Another purpose of the study was determination of cytotoxicity and antiviral activity of compounds on cell lines permissive for influenza virus and betacoronavirus.The antiviral activity of 6 adamantane derivatives against strains of the influenza virus (H1N1) and betacoronavirus was studied.It was established that the NO-donor derivative of aminoadamantane succinate and the dopamine derivative of adamantanebenzoic acid had the greatest ability to suppress the development of the influenza virus with a chemotherapeutic index above 60.No promising compounds against betacoronavirus were identified.

100 项与 Gurus Biopharm, Inc. 相关的药物交易

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2024年11月22日管线快照

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药物(靶点)	适应症	全球最高研发状态

地诺前列酮(Gurus) ( EP2 x EP4 x sGC )	哮喘更多	临床1期
前列地尔(Gurus) ( EP1 x EP4 x PGI2 receptor x sGC )	外周动脉疾病更多	临床1期
地诺前列素(Gurus) ( NOS x PGF2α )	视网膜疾患更多	临床前
GUR-701	脱发更多	未知